scholarly journals Plerixafor Overcomes the Adverse Effect of Diabetes on Hematopoietic Progenitor Cell Mobilization

2013 ◽  
Vol 19 (2) ◽  
pp. S192-S193
Author(s):  
Chunzhi Xia ◽  
Xiaobo Zhong ◽  
Dhakal Binod ◽  
Jonathan Thompson ◽  
Timothy Fenske ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Progenitor Cell ◽  
Hematopoietic Progenitor Cell ◽  
Hematopoietic Progenitor ◽  
Cell Mobilization

scholarly journals S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release

Blood ◽  
2012 ◽  
Vol 119 (11) ◽  
pp. 2478-2488 ◽  
Author(s):  
Karin Golan ◽  
Yaron Vagima ◽  
Aya Ludin ◽  
Tomer Itkin ◽  
Shiri Cohen-Gur ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Progenitor Cell ◽  
Hematopoietic Progenitor Cell ◽  
Hematopoietic Progenitors ◽  
Hematopoietic Progenitor ◽  
Ros Signaling ◽  
Sphingosine 1 Phosphate ◽  
Cell Mobilization ◽  
Elevated Rate

Abstract The mechanisms of hematopoietic progenitor cell egress and clinical mobilization are not fully understood. Herein, we report that in vivo desensitization of Sphingosine-1-phosphate (S1P) receptors by FTY720 as well as disruption of S1P gradient toward the blood, reduced steady state egress of immature progenitors and primitive Sca-1+/c-Kit+/Lin− (SKL) cells via inhibition of SDF-1 release. Administration of AMD3100 or G-CSF to mice with deficiencies in either S1P production or its receptor S1P1, or pretreated with FTY720, also resulted in reduced stem and progenitor cell mobilization. Mice injected with AMD3100 or G-CSF demonstrated transient increased S1P levels in the blood mediated via mTOR signaling, as well as an elevated rate of immature c-Kit+/Lin− cells expressing surface S1P1 in the bone marrow (BM). Importantly, we found that S1P induced SDF-1 secretion from BM stromal cells including Nestin+ mesenchymal stem cells via reactive oxygen species (ROS) signaling. Moreover, elevated ROS production by hematopoietic progenitor cells is also regulated by S1P. Our findings reveal that the S1P/S1P1 axis regulates progenitor cell egress and mobilization via activation of ROS signaling on both hematopoietic progenitors and BM stromal cells, and SDF-1 release. The dynamic cross-talk between S1P and SDF-1 integrates BM stromal cells and hematopoeitic progenitor cell motility.

scholarly journals Hematopoietic progenitor cell mobilization is more robust in healthy African American compared to Caucasian donors and is not affected by the presence of sickle cell trait

Transfusion ◽  
2016 ◽  
Vol 56 (5) ◽  
pp. 1058-1065 ◽  
Author(s):  
Sandhya R. Panch ◽  
Yu Ying Yau ◽  
Courtney D. Fitzhugh ◽  
Matthew M. Hsieh ◽  
John F. Tisdale ◽  
...  
Keyword(s):  
African American ◽  
Sickle Cell ◽  
Progenitor Cell ◽  
Sickle Cell Trait ◽  
Hematopoietic Progenitor Cell ◽  
Hematopoietic Progenitor ◽  
Cell Mobilization
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