scholarly journals Nicord® Expanded Hematopoietic Progenitor Cells (HPC) Are Capable of Outcompeting the Unmanipulated (UM) Cord Blood Unit and of Prolonged Myeloid and Lymphoid Engraftment Following Myeloablative Dual Umbilical Cord Blood (UCB) Transplantation

2013 ◽  
Vol 19 (2) ◽  
pp. S118 ◽  
Author(s):  
Mitchell E. Horwitz ◽  
Patrick J. Stiff ◽  
Nelson J. Chao ◽  
David Rizzieri ◽  
Gwynn Long ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor ◽  
Blood Unit ◽  
Cord Blood Unit

Separation of Hematopoietic Progenitor Cells from Human Umbilical Cord Blood

1993 ◽  
Vol 2 (2) ◽  
pp. 243-245 ◽  
Author(s):  
ARNON NAGLER ◽  
MARGO PEACOCK ◽  
MARISA TANTOCO ◽  
DONALD LAMONS ◽  
THOMAS B. OKARMA ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Progenitor Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Hematopoietic Progenitor

scholarly journals Biologic and phenotypic analysis of early hematopoietic progenitor cells in umbilical cord blood

Leukemia ◽  
1997 ◽  
Vol 11 (12) ◽  
pp. 2143-2149 ◽  
Author(s):  
C Almici ◽  
C Carlo-Stella ◽  
JE Wagner ◽  
L Mangoni ◽  
D Garau ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor ◽  
Phenotypic Analysis

scholarly journals Human Mesenchymal Stem/Stromal Cells from Umbilical Cord Blood and Placenta Exhibit Similar Capacities to Promote Expansion of Hematopoietic Progenitor Cells In Vitro

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Guadalupe R. Fajardo-Orduña ◽  
Héctor Mayani ◽  
Patricia Flores-Guzmán ◽  
Eugenia Flores-Figueroa ◽  
Erika Hernández-Estévez ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Stromal Cells ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor ◽  
Alternative Source

Mesenchymal stem/stromal cells (MSCs) from bone marrow (BM) have been used in coculture systems as a feeder layer for promoting the expansion of hematopoietic progenitor cells (HPCs) for hematopoietic cell transplantation. Because BM has some drawbacks, umbilical cord blood (UCB) and placenta (PL) have been proposed as possible alternative sources of MSCs. However, MSCs from UCB and PL sources have not been compared to determine which of these cell populations has the best capacity of promoting hematopoietic expansion. In this study, MSCs from UCB and PL were cultured under the same conditions to compare their capacities to support the expansion of HPCs in vitro. MSCs were cocultured with CD34+CD38−Lin− HPCs in the presence or absence of early acting cytokines. HPC expansion was analyzed through quantification of colony-forming cells (CFCs), long-term culture-initiating cells (LTC-ICs), and CD34+CD38−Lin− cells. MSCs from UCB and PL have similar capacities to increase HPC expansion, and this capacity is similar to that presented by BM-MSCs. Here, we are the first to determine that MSCs from UCB and PL have similar capacities to promote HPC expansion; however, PL is a better alternative source because MSCs can be obtained from a higher proportion of samples.

scholarly journals Effects of long-term cryopreservation on hematopoietic progenitor cells in umbilical cord blood

1999 ◽  
Vol 23 (4) ◽  
pp. 395-396 ◽  
Author(s):  
H Mugishima ◽  
K Harada ◽  
M Chin ◽  
T Suzuki ◽  
K Takagi ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor
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