scholarly journals Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation

2013 ◽  
Vol 19 (2) ◽  
pp. 274-282 ◽  
Author(s):  
Willemijn Hobo ◽  
Kelly Broen ◽  
Walter J.F.M. van der Velden ◽  
Annelies Greupink-Draaisma ◽  
Niken Adisty ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Relapse Free Survival ◽  
Histocompatibility Antigens ◽  
Free Survival ◽  
Minor Histocompatibility Antigens ◽  
Graft Versus Host

Genome-wide surveillance of mismatched alleles for graft-versus-host disease in stem cell transplantation

Blood ◽  
2015 ◽  
Vol 126 (25) ◽  
pp. 2752-2763 ◽  
Author(s):  
Aiko Sato-Otsubo ◽  
Yasuhito Nannya ◽  
Koichi Kashiwase ◽  
Makoto Onizuka ◽  
Fumihiro Azuma ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Histocompatibility Antigens ◽  
Minor Histocompatibility Antigens ◽  
Graft Versus Host ◽  
Genome Wide ◽  
Key Points ◽  
Candidate Loci

Key Points GWAS can identify allele mismatch associated with aGVHD development. Three novel candidate loci for minor histocompatibility antigens significantly associate with aGVHD.

Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation

Blood ◽  
2013 ◽  
Vol 121 (18) ◽  
pp. 3745-3758 ◽  
Author(s):  
Emily Blyth ◽  
Leighton Clancy ◽  
Renee Simms ◽  
Chun K. K. Ma ◽  
Jane Burgess ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Organ Damage ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points

Key Points Infusion of CMV-specific T cells early posttransplant does not increase acute or chronic graft-versus-host disease. CMV-specific T cells early posttransplant reduce the need for pharmacotherapy without increased rates of CMV-related organ damage.

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