scholarly journals Bone Health in Children and Adolescents Undergoing Hematopoietic Cell Transplantation in a Singapore Center

2012 ◽  
Vol 18 (2) ◽  
pp. S312-S313
Author(s):  
Z. Goh ◽  
S.L. Low ◽  
C. Khanlian ◽  
N.D.B. Mohamed Ismail ◽  
H.C. Chua ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Cell Transplantation ◽  
Bone Health ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell

Impact of Palifermin on Transplant Outcomes in Children and Adolescents Undergoing Allogeneic Hematopoietic Cell Transplantation

2020 ◽  
Vol 40 (11) ◽  
pp. 6531-6537
Author(s):  
KRZYSZTOF CZYŻEWSKI ◽  
ROBERT DĘBSKI ◽  
NATALIA BARTOSZEWICZ ◽  
EWA DEMIDOWICZ ◽  
MONIKA RICHERT-PRZYGOŃSKA ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Transplant Outcomes

scholarly journals Bone Health Assessment in Patients Undergoing Hematopoietic Cell Transplantation

2015 ◽  
Vol 21 (2) ◽  
pp. S178-S179
Author(s):  
Daniel Ernst ◽  
Pablo Florenzano ◽  
Claudia Campusano ◽  
Veronica Jara ◽  
Pablo Bertin ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Bone Health ◽  
Hematopoietic Cell Transplantation ◽  
Health Assessment ◽  
Hematopoietic Cell

scholarly journals Utility of Pre-Hematopoietic Cell Transplantation Sinus CT Screening in Children and Adolescents

2020 ◽  
Vol 41 (5) ◽  
pp. 911-916 ◽  
Author(s):  
J.H. Harreld ◽  
R.A. Kaufman ◽  
G. Kang ◽  
G. Maron ◽  
W. Mitchell ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Ct Screening

Bone Health Assesment in Patients Undergoing Hematopoietic Cell Transplantation

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 5886-5886
Author(s):  
Pablo Ramirez ◽  
Pablo Florenzano ◽  
Claudia Campusano ◽  
Veronica Jara ◽  
Pablo A Bertin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Cell Transplantation ◽  
Bone Health ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Main Diagnosis ◽  
Z Score ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Abstract INTRODUCTION: The increased survival of hematological patients has required to widen the care of these patients, with emphasis in factors related to quality of life and late mortality. Among them, osteoporosis (OP) is a fundamental problem. Patients undergoing hematopoietic cell transplantation (HCT) are at great risk of OP, mainly due to prolonged exposure to chemotherapy, immunosuppresants and the hypogonadism frequently associated to these treatments. Despite this, there is lack of strong evidence on this matter and HCT guidelines are not clear on this problem. OBJECTIVES: To evaluate parameters related to bone health in patients undergoing HCT. To measure the frequency and severity of the alterations in this group of patients. PATIENTS AND METHODS: Observational and retrospective analysis of patients undergoing HCT at the Catholic University Hematology-Oncology Department. All patients undergoing HCT were recommended to have determination of 25-OH vitamin D, PTHi, Calcium, Phosphorus and bone densitometry (DXA). We included all patients with the evaluation before HCT (preHCT) and 1 year after HCT (postHCT). RESULTS: We obtained data from 20 patients preHCT and 22 patients postHCT. Main diagnosis were acute myeloid leukemia (n=13; 32%), multiple myeloma (n=11; 26%), acute lymphoblastic leukemia (n=9; 21%) and Hodgkin's Lymphoma (n=5; 12%). Mean age was 40 years (range: 17-67) and 67% were males. In the preHCT group, the median 25-OH vitamin D levels were 13,6 ng/ml (range: 4,9-26,7 ng/ml) and 100% of the patients were in the insuficiency range leveles (<30 ng/ml). Median PTHi levels were 62,6 pg/ml (range: 24,4-223,7 pg/ml), and 46% of the patients had secondary hyperparathyroidism. In the postHCT group, median 25-OH vitamina D levels were 11,4 ng/ml (range: 4-29,4 ng/ml) and 100% had insuficiency levels. Median PTHi levels were 68 pg/ml (range: 37,4-135,8 pg/ml), and 56% of the patients had secondary hyperparathyroidism. 12 patients had DXA before HCT and 3 (25%) of them had DXA lumbar Z score less than -2.0. In 19 patients postHCT, 4 (21%) had decreased DXA Z score < 2.0. No difference could be established between autologus or allogeneic HCT in any meassurement. CONCLUSIONS: HCT patients represent a high risk group of developing severe vitamin D deficiency, secondary hyperparathyrodism and decreased DXA levels. These data are a warning that this population of patients requiere early intervention to prevent long term complications. This report is the initial evaluation for the development and treatment of bone health in a prospective matter in HCT patients in our center. Disclosures No relevant conflicts of interest to declare.

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