scholarly journals Anti-HLA Antibodies in Double Umbilical Cord Blood Transplantation

2011 ◽  
Vol 17 (11) ◽  
pp. 1704-1708 ◽  
Author(s):  
Claudio G. Brunstein ◽  
Harriet Noreen ◽  
Todd E. DeFor ◽  
David Maurer ◽  
Jeffrey S. Miller ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cord Blood Transplantation ◽  
Umbilical Cord Blood Transplantation ◽  
Hla Antibodies ◽  
Blood Transplantation

scholarly journals Donor-specific anti-HLA antibodies predict outcome in double umbilical cord blood transplantation

Blood ◽  
2011 ◽  
Vol 118 (25) ◽  
pp. 6691-6697 ◽  
Author(s):  
Corey Cutler ◽  
Haesook T. Kim ◽  
Lixian Sun ◽  
Doreen Sese ◽  
Brett Glotzbecker ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Graft Failure ◽  
Cord Blood Transplantation ◽  
Umbilical Cord Blood Transplantation ◽  
Hla Antibodies ◽  
Fluorescent Intensity ◽  
Blood Transplantation

Abstract Using a uniform detection method for donor-specific anti-HLA antibodies (DSAs), we sought to determine the effect of preformed DSAs on outcomes in double umbilical cord blood transplantation. DSAs were associated with an increased incidence of graft failure (5.5% vs 18.2% vs 57.1% for none, single, or dual DSA positivity; P = .0001), prolongation of the time to neutrophil engraftment (21 vs 29 days for none vs any DSA; P = .04), and excess 100-day mortality or relapse (23.6% vs 36.4% vs 71.4% for none, single, or dual DSA positivity; P = .01). The intensity of DSA reactivity was correlated with graft failure (median of mean fluorescent intensity 17 650 vs 1 850; P = .039). There was inferior long-term progression-free and overall survival when comparing patients with DSAs against both umbilical cord blood units to those without DSAs (3-year progression-free survival, 0% vs 33.5%, P = .004; 3-year overall survival 0% vs 45.0%, P = .04). We conclude that identification of preformed DSAs in umbilical cord blood recipients should be performed and that the use of umbilical cord blood units where preformed host DSAs exist should be avoided.

Intrabone infusion for allogeneic umbilical cord blood transplantation in children

2021 ◽  
Author(s):  
Stephanie Vairy ◽  
Isabelle Louis ◽  
Marie-France Vachon ◽  
Johanne Richer ◽  
Pierre Teira ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cord Blood Transplantation ◽  
Umbilical Cord Blood Transplantation ◽  
Blood Transplantation

Primary research on unrelated double umbilical cord blood transplantation and implantation kinetics

Hematology ◽  
2013 ◽  
Vol 18 (5) ◽  
pp. 253-259 ◽  
Author(s):  
Kaidi Song ◽  
Zimin Sun ◽  
Huilan Liu ◽  
Liangquan Geng ◽  
Kaiyang Ding ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cord Blood Transplantation ◽  
Umbilical Cord Blood Transplantation ◽  
Primary Research ◽  
Blood Transplantation
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