scholarly journals Host Natural Killer T Cells Induce an IL-4 Dependent Expansion of Donor CD4+CD25+Foxp3+ Tregs That Protects Against Lethal Acute Graft-Versus-Host Disease

2009 ◽  
Vol 15 (2) ◽  
pp. 14
Author(s):  
A.B. Pillai ◽  
T.I. George ◽  
S. Dutt ◽  
S. Strober
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Graft Versus Host Disease ◽  
Natural Killer T Cells ◽  
Host Disease ◽  
Graft Versus Host ◽  
Killer T Cells ◽  
Acute Graft ◽  
Natural Killer T

Modulation of acute graft-versus-host disease and chimerism after adoptive transfer of in vitro-expanded invariant Vα14 natural killer T cells

2006 ◽  
Vol 106 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Masaki Kuwatani ◽  
Yoshinori Ikarashi ◽  
Akira Iizuka ◽  
Chihiro Kawakami ◽  
Gary Quinn ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Graft Versus Host Disease ◽  
Adoptive Transfer ◽  
Natural Killer T Cells ◽  
Host Disease ◽  
Graft Versus Host ◽  
Killer T Cells ◽  
Acute Graft

scholarly journals Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4–dependent mechanism

Blood ◽  
2011 ◽  
Vol 117 (11) ◽  
pp. 3220-3229 ◽  
Author(s):  
Dennis B. Leveson-Gower ◽  
Janelle A. Olson ◽  
Emanuela I. Sega ◽  
Richard H. Luong ◽  
Jeanette Baker ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Graft Versus Host Disease ◽  
B Cell Lymphoma ◽  
Nkt Cells ◽  
Host Disease ◽  
Graft Versus Host ◽  
Gastrointestinal Pathology ◽  
Dependent Mechanism ◽  
Natural Killer T

Abstract CD4+ natural killer T (NKT) cells, along with CD4+CD25+ regulatory T cells (Tregs), are capable of controlling aberrant immune reactions. We explored the adoptive transfer of highly purified (> 95%) CD4+NKT cells in a murine model of allogeneic hematopoietic cell transplantation (HCT). NKT cells follow a migration and proliferation pattern similar to that of conventional T cells (Tcons), migrating initially to secondary lymphoid organs followed by infiltration of graft-versus-host disease (GVHD) target tissues. NKT cells persist for more than 100 days and do not cause significant morbidity or mortality. Doses of NKT cells as low as 1.0 × 104 cells suppress GVHD caused by 5.0 × 105 Tcons in an interleukin-4 (IL-4)–dependent mechanism. Protective doses of NKT cells minimally affect Tcon proliferation, but cause significant reductions in interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) production by donor Tcons and in skin, spleen, and gastrointestinal pathology. In addition, NKT cells do not impact the graft-versus-tumor (GVT) effect of Tcons against B-cell lymphoma-1 (BCL-1) tumors. These studies elucidate the biologic function of donor-type CD4+NKT cells in suppressing GVHD in an allogeneic transplantation setting, demonstrating clinical potential in reducing GVHD in HCT.

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