scholarly journals Early Recovery of CD4 T Cell Receptor Diversity after “Lymphoablative” Conditioning and Autologous CD34 Cell Transplantation

2008 ◽  
Vol 14 (12) ◽  
pp. 1373-1379 ◽  
Author(s):  
Jan Storek ◽  
Zhao Zhao ◽  
Yiping Liu ◽  
Richard Nash ◽  
Peter McSweeney ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Transplantation ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Early Recovery

scholarly journals Progression of Human Immunodeficiency Virus Disease Is Associated with Increasing Disruptions within the CD4+T Cell Receptor Repertoire

1998 ◽  
Vol 177 (3) ◽  
pp. 579-585 ◽  
Author(s):  
Juan C. Gea‐Banacloche ◽  
Emma E. Weiskopf ◽  
Claire Hallahan ◽  
Juan Carlos López Bernaldo de Quirós ◽  
Mark Flanigan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
T Cell Receptor ◽  
Virus Disease ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Receptor Repertoire ◽  
Immunodeficiency Virus ◽  
T Cell Receptor Repertoire ◽  
Cell Receptor Repertoire

CD4+ T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals

Blood ◽  
2008 ◽  
Vol 111 (4) ◽  
pp. 2053-2061 ◽  
Author(s):  
Laura Crompton ◽  
Naeem Khan ◽  
Rajiv Khanna ◽  
Laxman Nayak ◽  
Paul A. H. Moss
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Response ◽  
Cd4 T Cells ◽  
Clonal Selection ◽  
Cell Receptor ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Extreme Conservation

Antigen-specific CD8+ cytotoxic T cells often demonstrate extreme conservation of T-cell receptor (TCR) usage between different individuals, but similar characteristics have not been documented for CD4+ T cells. CD4+ T cells predominantly have a helper immune role, but a cytotoxic CD4+ T-cell subset has been characterized, and we have studied the cytotoxic CD4+ T-cell response to a peptide from human cytomegalovirus glycoprotein B presented through HLA-DRB*0701. We show that this peptide elicits a cytotoxic CD4+ T-cell response that averages 3.6% of the total CD4+ T-cell repertoire of cytomegalovirus-seropositive donors. Moreover, CD4+ cytotoxic T-cell clones isolated from different individuals exhibit extensive conservation of TCR usage, which indicates strong T-cell clonal selection for peptide recognition. Remarkably, this TCR sequence was recently reported in more than 50% of cases of CD4+ T-cell large granular lymphocytosis. Immunodominance of cytotoxic CD4+ T cells thus parallels that of CD8+ subsets and suggests that cytotoxic effector function is critical to the development of T-cell clonal selection, possibly from immune competition secondary to lysis of antigen-presenting cells. In addition, these TCR sequences are highly homologous to those observed in HLA-DR7+ patients with CD4+ T-cell large granular lymphocytosis and implicate cytomegalovirus as a likely antigenic stimulus for this disorder.

scholarly journals Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation

Leukemia ◽  
2019 ◽  
Vol 34 (5) ◽  
pp. 1422-1432 ◽  
Author(s):  
Stéphane Buhler ◽  
Florence Bettens ◽  
Carole Dantin ◽  
Sylvie Ferrari-Lacraz ◽  
Marc Ansari ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Hematopoietic Stem

scholarly journals T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

Immunity ◽  
2014 ◽  
Vol 41 (1) ◽  
pp. 63-74 ◽  
Author(s):  
Nicholas van Panhuys ◽  
Frederick Klauschen ◽  
Ronald N. Germain
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Signal Intensity ◽  
Cell Receptor ◽  
Cell Polarization ◽  
Cd4 T Cell ◽  
Dependent Signal ◽  
T Cell Polarization
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