scholarly journals 310: Rapid Engraftment and Low Rates of Graft-versus-host Disease (GVHD) Following Reduced Intensity Conditioning (RIC) with Fludarabine/Busulfan/ATG (FBA) and Stem Cell Transplantation (SCT) using Unrelated Donors (URD)

2008 ◽  
Vol 14 (2) ◽  
pp. 114-115
Author(s):  
M. Hamadani ◽  
F.T. Awan ◽  
P. Elder ◽  
T.S. Lin ◽  
L. Andritsos ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Reduced Intensity Conditioning ◽  
Host Disease ◽  
Graft Versus Host ◽  
Unrelated Donors ◽  
Reduced Intensity

scholarly journals Bortezomib, tacrolimus, and methotrexate for prophylaxis of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation from HLA-mismatched unrelated donors

Blood ◽  
2009 ◽  
Vol 114 (18) ◽  
pp. 3956-3959 ◽  
Author(s):  
John Koreth ◽  
Kristen E. Stevenson ◽  
Haesook T. Kim ◽  
Michael Garcia ◽  
Vincent T. Ho ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Cumulative Incidence ◽  
Reduced Intensity Conditioning ◽  
Graft Versus Host ◽  
Unrelated Donors ◽  
Reduced Intensity

Abstract Graft-versus-host disease (GVHD) is a significant complication of allogeneic stem cell transplantation (alloSCT). The proteasome inhibitor bortezomib has immunomodulatory properties of potential benefit for GVHD control. We undertook a phase 1 trial of bortezomib, tacrolimus, and methotrexate for GVHD prophylaxis after reduced-intensity conditioning alloSCT using human leukocyte antigen–mismatched unrelated donors. Twenty-three patients were enrolled. Bortezomib dose levels of 1, 1.3, and 1.5 mg/m2 were evaluated with 5, 3, and 5 patients, respectively. Ten additional patients were accrued at the 1.3 mg/m2 bortezomib dose level. Bortezomib-related toxicity was minimal. With a 12-month median follow-up, grade II-IV acute GVHD occurred in 3 patients, a 180-day cumulative incidence of 13%. Chronic GVHD occurred in 9 patients, a 1-year cumulative incidence of 41%. At 1-year, the nonrelapse mortality was zero, cumulative incidence of relapse/progression was 29%, and overall, progression-free, and event-free survival were 75%, 64%, and 59%, respectively. Bortezomib is a promising novel immunomodulatory agent in allogeneic transplantation. This study was registered at http://www.clinicaltrials.gov as #NCT00369226.

Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation

Blood ◽  
2005 ◽  
Vol 106 (13) ◽  
pp. 4407-4411 ◽  
Author(s):  
Mohamad Mohty ◽  
Didier Blaise ◽  
Catherine Faucher ◽  
Norbert Vey ◽  
Reda Bouabdallah ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Inflammatory Cytokines ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Reduced Intensity Conditioning ◽  
Graft Versus Host ◽  
Reduced Intensity ◽  
Acute Graft

This study investigated the role of inflammatory cytokines in acute graft-versus-host disease (aGVHD) incidence and severity in 113 patients who underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT). Among all tested cytokines in the first 3 months after allo-SCT, only interleukin-12 p70 (IL-12p70) levels in the first month were significantly associated with grades II to IV aGVHD development (P < .001). IL-12p70 levels were directly correlated with aGVHD severity grade (P < .001). Before aGVHD onset, blood monocytes, the main precursor pool of IL12p70-secreting dendritic cells, recovered more rapidly in patients with grades II to IV aGVHD (P = .005). Similarly, at the effector level, there was a more robust reconstitution of naive CD3+CD4+CD45RA+CD27+ T cells in patients developing grades II to IV aGVHD (P = .006). In multivariate analysis, IL-12p70 level measured in the first month was the strongest predictive factor for aGVHD development (P < .001). These findings, reconstituting a TH1 loop, support a model in which aGVHD reflects a type 1 alloreaction after RIC allo-SCT.

Characterization of acute graft-versus-host disease following reduced-intensity stem-cell transplantation from an HLA-identical related donor

2008 ◽  
Vol 83 (8) ◽  
pp. 630-634 ◽  
Author(s):  
Naoko Murashige ◽  
Masahiro Kami ◽  
Shin-ichiro Mori ◽  
Yuta Katayama ◽  
Kazuhiko Kobayashi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Related Donor ◽  
Reduced Intensity ◽  
Acute Graft
Sign in / Sign up

Export Citation Format

Share Document