scholarly journals 158: Relapse of Acute Myeloid Leukmia after Allogeneic Stem-Cell Transplantation (SCT) with Myeloablative Conditioning is Associated with Longer Survival than Relapse after Reduced-Intensity Conditioning (RIC)

2008 ◽  
Vol 14 (2) ◽  
pp. 59-60
Author(s):  
A. Shimoni ◽  
I. Hardan ◽  
N. Shem-Tov ◽  
A. Rand ◽  
E. Ribakovsky ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Reduced Intensity Conditioning ◽  
Myeloablative Conditioning ◽  
Reduced Intensity ◽  
Acute Myeloid

Reduced-Intensity Conditioning Compared With Conventional Allogeneic Stem-Cell Transplantation in Relapsed or Refractory Hodgkin's Lymphoma: An Analysis From the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation

2008 ◽  
Vol 26 (3) ◽  
pp. 455-462 ◽  
Author(s):  
Anna Sureda ◽  
Stephen Robinson ◽  
Carmen Canals ◽  
Angelo M. Carella ◽  
Marc A. Boogaerts ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Marrow Transplantation ◽  
Reduced Intensity Conditioning ◽  
Myeloablative Conditioning ◽  
Blood And Marrow Transplantation ◽  
European Group ◽  
Reduced Intensity

Purpose To compare the clinical outcome in terms of nonrelapse mortality (NRM), relapse rate (RR), overall survival (OS), and progression-free survival (PFS) in patients with relapsed Hodgkin's lymphoma (HL) treated with reduced-intensity conditioning (RIC) or myeloablative conditioning followed by allogeneic stem-cell transplantation (alloSCT). Patients and Methods A total of 168 patients with HL undergoing a first alloSCT (RIC, n = 89; myeloablative conditioning, n = 79) between January 1997 and December 2001 and registered in the European Group for Blood and Marrow Transplantation database were analyzed. Results NRM was significantly decreased in the RIC group (hazard ratio [HR], 2.85; 95% CI, 1.62 to 5.02; P < .001). OS was better in the RIC group (HR, 2.05; 95% CI, 1.27 to 3.29; P = .04) and there was a trend for better PFS in the RIC group (HR, 1.53; 95% CI, 0.97 to 2.40; P = .07). RR was higher in the RIC group in univariate but not in multivariate analysis. The development of chronic graft-versus-host disease (GVHD) significantly decreased the incidence of relapse, which translated into a trend for a better PFS. Conclusion The lower incidence of NRM in the RIC group is encouraging, particularly because these patients experienced adverse pretransplantation characteristics more frequently. This analysis also indicates the existence of a graft-versus-HL effect correlated to the development of GVHD. Additional efforts to reduce the high RR seen in both groups of patients will be necessary to improve the modest PFS (31% v 27%) and OS (59% v 36%) for patients prepared with RIC or myeloablative conditioning.

scholarly journals Outpatient reduced intensity conditioning allogeneic stem cell transplantation for acute myeloid leukaemia in children

2010 ◽  
Vol 151 (2) ◽  
pp. 200-202
Author(s):  
Laura Rodríguez-Romo ◽  
Consuelo Mancias-Guerra ◽  
Oscar González-Llano ◽  
José Carlos Jaime-Pérez ◽  
Sylvia Martínez-Cabriales ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Reduced Intensity Conditioning ◽  
Reduced Intensity ◽  
Acute Myeloid
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