scholarly journals Pure White Cell Aplasia (PWCA) Relapsing after Allogeneic BMT and Successfully Treated with Nine DLIs

2006 ◽  
Vol 12 (9) ◽  
pp. 987-989 ◽  
Author(s):  
A.M. Marmont ◽  
A. Dominietto ◽  
F. Gualandi ◽  
G. Piaggio ◽  
M.T. van Lint ◽  
...  
Keyword(s):  
White Cell ◽  
Allogeneic Bmt ◽  
Pure White

scholarly journals Acquired idiopathic pure white cell aplasia: A rare cause of agranulocytosis

2014 ◽  
Vol 5 (4) ◽  
pp. 161
Author(s):  
Sadia Sultan ◽  
SyedMohammad Irfan
Keyword(s):  
White Cell ◽  
Pure White

Pure white cell aplasia

1993 ◽  
Vol 23 (5) ◽  
pp. 525-526
Author(s):  
M. S. WARD ◽  
G. P. M. CRAWFORD
Keyword(s):  
White Cell ◽  
Pure White

scholarly journals Chlorpropamide-induced pure white cell aplasia

Blood ◽  
1987 ◽  
Vol 69 (2) ◽  
pp. 394-400
Author(s):  
LJ Levitt
Keyword(s):  
Drug Exposure ◽  
Selective Inhibition ◽  
White Cell ◽  
Chl A ◽  
Toxic Drug ◽  
Control Serum ◽  
Potent Drug ◽  
Wbc Count ◽  
Pure White

We investigated the mechanism for isolated agranulocytosis and marrow pure white cell aplasia in an elderly man receiving 0.5 to 1.0 g per day of chlorpropamide (Chl) without other toxic drug exposure or overt systemic illness. Patient marrow revealed an absence of recognizable granulocytic precursors; megakaryocytes and erythroid precursors were normal. The WBC count was 1800/mm3 on admission with only 2% neutrophils; the absolute neutrophil count first exceeded 500/mm3 on the 17th day following cessation of Chl. A serum Chl level on admission was 100 micrograms/mL (acute phase, AP); no Chl was detected in serum (convalescent phase, CP) assessed on the 22nd hospital day. Antineutrophil antibodies were not detected, and T cell depletion failed to augment patient in vitro granulopoiesis. Patient AP serum produced potent complement-mediated inhibition (87% +/- 7%) of autologous granulocyte progenitors (CFU-GM) with minimal inhibition of erythroid (11% +/- 5%) or multipotent (5% +/- 4%) progenitor cells. Selective inhibition by patient AP serum of CFU-GM (74% +/- 11%) was also seen against two allogeneic marrows. Patient CP serum no longer inhibited (6% +/- 4%) autologous CFU-GM. Addition of Chl (5 to 120 micrograms/mL) to CP serum but not to control serum resulted in potent drug concentration-dependent complement-mediated inhibition of autologous and allogeneic CFU-GM. Inhibition of CFU-GM in the presence of Chl was no longer demonstrable following immunoabsorbent removal of IgG from patient serum. Patient serum in the presence of Chl had limited activity against morphologically recognizable marrow granulocytic precursors in a microimmunofluorescence assay. These results are most consistent with the development of Chl-dependent, selective antibody-mediated immune inhibition of granulopoiesis.

scholarly journals A portion of expanded granular lymphocytes cause pure white cell aplasia?

2018 ◽  
Vol 97 (10) ◽  
pp. 1995-1997
Author(s):  
Yasushi Isobe ◽  
Yu Uemura ◽  
Akiko Uchida ◽  
Ikuo Miura
Keyword(s):  
White Cell ◽  
Granular Lymphocytes ◽  
Pure White

scholarly journals Complete remission of pure white cell aplasia associated with thymoma, autoimmune thyroiditis and type 1 diabetes

2003 ◽  
Vol 70 (3) ◽  
pp. 186-189 ◽  
Author(s):  
Zina Fumeaux ◽  
Photis Beris ◽  
Bettina Borisch ◽  
François P. Sarasin ◽  
Eddy Roosnek ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Complete Remission ◽  
Autoimmune Thyroiditis ◽  
White Cell ◽  
Pure White

scholarly journals Pure White Cell Aplasia and Necrotizing Myositis

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Peter Geon Kim ◽  
Joome Suh ◽  
Max W. Adelman ◽  
Kwadwo Oduro ◽  
Erik Williams ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Liver Injury ◽  
White Cell ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Drug Induced ◽  
Hematologic Disorder ◽  
Necrotizing Myositis ◽  
Stimulating Factor ◽  
Pure White

Pure white cell aplasia (PWCA) is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow with intact megakaryopoiesis and erythropoiesis. PWCA has been associated with autoimmune, drug-induced, and viral exposures. Here, we report a case of a 74-year-old female who presented with severe proximal weakness without pain and was found to have PWCA with nonspecific inflammatory necrotizing myositis and acute liver injury on biopsies. These findings were associated with a recent course of azithromycin and her daily use of a statin. Myositis improved on prednisone but PWCA persisted. With intravenous immunoglobulin and granulocyte-colony stimulating factor therapies, her symptoms and neutrophil counts improved and were sustained for months.

scholarly journals Drug Induced Pure White Cell Aplasia: A Case Report and Review of Literature

2017 ◽  
Vol 2 (2) ◽  
pp. 88-91
Author(s):  
Aisha Jamal ◽  
Uzma Zaidi ◽  
Jawad Hasan Kazmi ◽  
Munira Borhany ◽  
Quratulain Rizvi ◽  
...  
Keyword(s):  
Case Report ◽  
White Cell ◽  
Review Of Literature ◽  
Drug Induced ◽  
Pure White

scholarly journals Pure White Cell Aplasia an exceptional condition in the inmunological conundrum of thymomas: Responses to inmunosupresion and Literature Review.

2021 ◽  
Author(s):  
Roberto Céspedes López ◽  
Elena Amutio ◽  
Xabier Martín Martitegui ◽  
Amaia Balerdi Malcorra ◽  
Lucia Insunza Oleaga ◽  
...  
Keyword(s):  
Literature Review ◽  
White Cell ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Good Syndrome ◽  
Stimulating Factor ◽  
Factor G ◽  
Pure White

Thymomas are tumours frequently associated with autoinmune manifestations or immunodeficiencies like Good syndrome. In rare cases, pure white cells aplasia (PWCA) has been described in association with thymomas. PWCA is characterized by agranulocytosis of autoinmune background primary refractory to granulocyte colony-stimulating factor (G-CSF). It is necessary to use inmunosupressor drugs.

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