scholarly journals Effect of Body Mass Index on Mortality of Patients with Lymphoma Undergoing Autologous Hematopoietic Cell Transplantation

2006 ◽  
Vol 12 (5) ◽  
pp. 541-551 ◽  
Author(s):  
Willis H. Navarro ◽  
Fausto R. Loberiza ◽  
Ruta Bajorunaite ◽  
Koen van Besien ◽  
Julie M. Vose ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cell Transplantation ◽  
Body Mass ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Autologous Hematopoietic Cell Transplantation

scholarly journals Pediatric hematopoietic cell transplantation: Longitudinal trends in body mass index and outcomes

2020 ◽  
Vol 24 (7) ◽  
Author(s):  
Brian Norman Dang ◽  
Holly Wilhalme ◽  
James Ch'ng ◽  
Satiro De Oliveira ◽  
LaVette Bowles ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cell Transplantation ◽  
Body Mass ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell

scholarly journals Donor body mass index does not predict graft versus host disease following hematopoietic cell transplantation

2018 ◽  
Vol 53 (7) ◽  
pp. 932-937
Author(s):  
Lucie M. Turcotte ◽  
Tao Wang ◽  
Michael T. Hemmer ◽  
Stephen R. Spellman ◽  
Mukta Arora ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cell Transplantation ◽  
Body Mass ◽  
Graft Versus Host Disease ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Pediatric Hematopoietic Cell Transplantation: Longitudinal Trends in Body Mass Index and Outcomes

2020 ◽  
Author(s):  
Brian Dang ◽  
Holly Wilhalme ◽  
James Ch ng ◽  
Satiro De Oliveira ◽  
Lavette Bowles ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cell Transplantation ◽  
Body Mass ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell

Autologous Hematopoietic Cell Transplantation in Patients With Multiple Myeloma: Effect of Age

2017 ◽  
Vol 17 (3) ◽  
pp. 165-172 ◽  
Author(s):  
Binod Dhakal ◽  
Ariel Nelson ◽  
Guru Subramanian Guru Murthy ◽  
Raphael Fraser ◽  
Daniel Eastwood ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Effect Of Age ◽  
Autologous Hematopoietic Cell Transplantation

Longitudinal Assessment of Hematopoietic Abnormalities After Autologous Hematopoietic Cell Transplantation for Lymphoma

2005 ◽  
Vol 23 (27) ◽  
pp. 6699-6711 ◽  
Author(s):  
Ravi Bhatia ◽  
Khristine Van Heijzen ◽  
Ann Palmer ◽  
Asako Komiya ◽  
Marilyn L. Slovak ◽  
...  
Keyword(s):  
Stem Cells ◽  
Telomere Length ◽  
Cell Transplantation ◽  
Hodgkin’S Lymphoma ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Hodgkin's Lymphoma ◽  
Autologous Hct ◽  
Prospective Longitudinal ◽  
Autologous Hematopoietic Cell Transplantation

Purpose Autologous hematopoietic cell transplantation (HCT) is being increasingly used as an effective treatment strategy for patients with relapsed or refractory Hodgkin's lymphoma (HL) or non-Hodgkin's lymphoma (NHL) but is associated with therapy-related myelodysplasia and acute myeloid leukemia (t-MDS/AML) as a major cause of nonrelapse mortality. The phenomenon of hematopoietic reconstitution after autologous HCT and the role of proliferative stress in the pathogenesis of t-MDS/AML are poorly understood. Patients and Methods Using a prospective longitudinal study design, we evaluated the nature and timing of alterations in hematopoietic progenitors and telomere length after HCT in patients undergoing autologous HCT at City of Hope Cancer Center (Duarte, CA). Results A significant reduction in primitive and committed progenitors was observed before HCT compared with healthy controls. Further profound and persistent reduction in primitive progenitors but only transient reduction in committed progenitors were seen after HCT. Primitive progenitor frequency in pre-HCT marrow and peripheral-blood stem cells predicted for primitive progenitor recovery after HCT. Shortening of telomere length was observed in marrow cells early after HCT, with subsequent restoration to pre-HCT levels. Patients within this cohort who developed t-MDS/AML had reduced recovery of committed progenitors and poorer telomere recovery, possibly indicating a functional defect in primitive hematopoietic cells. Conclusion Our studies suggest that hematopoietic regeneration after HCT is associated with increased proliferation and differentiation of primitive progenitors. Increased proliferative stress on stem cells bearing genotoxic damage could contribute to the pathogenesis of t-MDS/AML. Extended follow-up of a larger number of patients is required to confirm whether alterations in progenitor and telomere recovery predict for increased risk of t-MDS/AML.

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