scholarly journals Bone marrow transplantation for acute myeloid leukemia from donor with Gaucher disease followed by Enzyme Replacement Therapy (ERT)

2006 ◽  
Vol 12 (2) ◽  
pp. 45-46
Author(s):  
M. Mrsic ◽  
B. Labar ◽  
K. Potocki ◽  
K. Fumic ◽  
R. Stern-Padovan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Bone Marrow Transplantation ◽  
Enzyme Replacement Therapy ◽  
Replacement Therapy ◽  
Marrow Transplantation ◽  
Gaucher Disease ◽  
Myeloid Leukemia ◽  
Enzyme Replacement ◽  
Acute Myeloid

Improvement in outcome for children receiving allogeneic bone marrow transplantation in first remission of acute myeloid leukemia: a report from the Groupe d'Etude des Greffes de Moelle Osseuse.

1992 ◽  
Vol 10 (12) ◽  
pp. 1865-1869 ◽  
Author(s):  
G Michel ◽  
E Gluckman ◽  
D Blaise ◽  
H Esperou-Bourdeau ◽  
J P Vernant ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Myeloid Leukemia ◽  
Acute Gvhd ◽  
Short Time Interval ◽  
Allogeneic Bone ◽  
Term Survival ◽  
Acute Myeloid

PURPOSE We retrospectively analyzed the outcome of children with acute myeloid leukemia (AML) in first complete remission (CR) who received HLA-identical bone marrow transplantation (BMT) in 13 French transplant centers. PATIENTS AND METHODS Seventy-four children were treated from June 1979 through December 1990. The conditioning regimen included total-body irradiation (TBI) in 54 cases and busulfan in 20. Prophylaxis of graft-versus-host disease (GVHD) consisted of cyclosporine (CycloA) plus methotrexate (MTX) for 38 patients, MTX for 17, CycloA for 18, and T depletion without other prophylaxis for one. The mean value of the interval from diagnosis to transplantation was 167 days. RESULTS Sixteen patients died of transplant-related complications, 12 relapsed, and 46 are alive in continuous remission with a median follow-up of 46 months. We examined results obtained over three successive periods: 1979 to 1982 (n = 14 children), 1983 to 1986 (n = 29), and 1987 to 1990 (n = 31). Probabilities of event-free survival (EFS) were 43%, 48%, and 82% for the three successive periods, respectively (P < .02). This improvement in EFS was linked to a decreased risk of transplant-related mortality: 36%, 36%, and 3%, respectively (P < .01). Other factors associated with a better EFS in the univariate analysis were a short time interval from diagnosis to transplant (< 120 days), the absence of significant (grade > or = 2) acute GVHD, and the absence of chronic GVHD. In the multivariate analysis, two factors had a favorable impact on long-term survival: the year of transplantation (years 1987 to 1990 v others) and the absence of acute GVHD. CONCLUSION The outcome for children receiving allogeneic BMT in first CR of AML has improved in France during recent years.

scholarly journals Bone marrow transplantation and acute myeloid leukemia: Brazilian guidelines

2013 ◽  
Vol 35 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Lucia Mariano da Rocha Silla ◽  
Frederico Dulley ◽  
Rosaura Saboya ◽  
Eduardo Paton ◽  
Fabio Kerbauy ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Myeloid Leukemia ◽  
Acute Myeloid
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