scholarly journals Long-Term Follow-up of Allogeneic Marrow Transplantation for Acute Myelogenous Leukemia after Treatment with Busulfan and Cyclophosphamide

2006 ◽  
Vol 12 (3) ◽  
pp. 366-367 ◽  
Author(s):  
Javier Bolaños-Meade ◽  
Eric Hartley ◽  
Richard J. Jones
Keyword(s):  
Acute Myelogenous Leukemia ◽  
Marrow Transplantation ◽  
Myelogenous Leukemia ◽  
Long Term Follow Up ◽  
Acute Myelogenous ◽  
Allogeneic Marrow Transplantation ◽  
Allogeneic Marrow

scholarly journals Long-term remission from acute myelogenous leukemia after bone marrow transplantation and recovery from acute graft-versus-host reaction and prolonged immunoincompetence

Blood ◽  
1975 ◽  
Vol 45 (2) ◽  
pp. 171-181 ◽  
Author(s):  
WA Bleyer ◽  
RM Blaese ◽  
JS Bujak ◽  
GP Herzig ◽  
RG Jr Graw
Keyword(s):  
Bone Marrow ◽  
Acute Myelogenous Leukemia ◽  
Marrow Transplantation ◽  
Myelogenous Leukemia ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
Graft Versus Host ◽  
Acute Myelogenous ◽  
Allogeneic Marrow

Abstract A 19-yr-old boy has been in continuous complete remission from acute myelogenous leukemia for 3 yr after allogeneic bone marrow transplantation prepared with combination chemotherapy. During the first year post-transplant, however, the patient developed near-fatal graft-versus-host reaction followed by 11 severe viral and bacterial infections. Immune evaluation during this period revealed multiple defects which were not present prior to transplantation, nor present in the transplant donor: diminution of lymphoid tissue, decline of all immunoglobulin subtypes, deletion of secretory immunoglobulin, disappearance of isohemagglutinins, loss of antibody to diptheria and tetanus toxoids, cessation of cutaneous hypersensitivity to mumps antigen, and inhibition of serum opsonizing activity. The patient was also unable to develop normal humoral or cellular reactivity to brucella antigen, keyhole limpet hemocyanin, or dinitrochlorobenzene. This patient's course illustrates the severity and chronicity of immunoincompetence associated with allogeneic marrow grafting, the importance of early detection and rigorous treatment of infectious disease in these patients, and the need for improved immunologic reconstitution in human marrow transplantation. It also indicates that complete recovery from the immune defects is possible, and that long- term remission from acute myelogenous leukemia can be achieved with allogeneic marrow transplantation.

scholarly journals Long-term remission from acute myelogenous leukemia after bone marrow transplantation and recovery from acute graft-versus-host reaction and prolonged immunoincompetence

Blood ◽  
1975 ◽  
Vol 45 (2) ◽  
pp. 171-181
Author(s):  
WA Bleyer ◽  
RM Blaese ◽  
JS Bujak ◽  
GP Herzig ◽  
RG Jr Graw
Keyword(s):  
Bone Marrow ◽  
Acute Myelogenous Leukemia ◽  
Marrow Transplantation ◽  
Myelogenous Leukemia ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
Graft Versus Host ◽  
Acute Myelogenous ◽  
Allogeneic Marrow

A 19-yr-old boy has been in continuous complete remission from acute myelogenous leukemia for 3 yr after allogeneic bone marrow transplantation prepared with combination chemotherapy. During the first year post-transplant, however, the patient developed near-fatal graft-versus-host reaction followed by 11 severe viral and bacterial infections. Immune evaluation during this period revealed multiple defects which were not present prior to transplantation, nor present in the transplant donor: diminution of lymphoid tissue, decline of all immunoglobulin subtypes, deletion of secretory immunoglobulin, disappearance of isohemagglutinins, loss of antibody to diptheria and tetanus toxoids, cessation of cutaneous hypersensitivity to mumps antigen, and inhibition of serum opsonizing activity. The patient was also unable to develop normal humoral or cellular reactivity to brucella antigen, keyhole limpet hemocyanin, or dinitrochlorobenzene. This patient's course illustrates the severity and chronicity of immunoincompetence associated with allogeneic marrow grafting, the importance of early detection and rigorous treatment of infectious disease in these patients, and the need for improved immunologic reconstitution in human marrow transplantation. It also indicates that complete recovery from the immune defects is possible, and that long- term remission from acute myelogenous leukemia can be achieved with allogeneic marrow transplantation.

Long-term follow-up of patients with acute myelogenous leukemia receiving an autologous telomerase-based dendritic cell vaccine.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 7007-7007
Author(s):  
Hanna Jean Khoury ◽  
Robert Collins ◽  
William G. Blum ◽  
Patrick J. Stiff ◽  
Jane Lebkowski ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Acute Myelogenous Leukemia ◽  
Dendritic Cell Vaccine ◽  
Myelogenous Leukemia ◽  
Cell Vaccine ◽  
Long Term Follow Up ◽  
Acute Myelogenous
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