scholarly journals Separation of CD4+ T cell-mediated graft-versus-host responses from the graft-versus-leukemia effect

2005 ◽  
Vol 11 (2) ◽  
pp. 50
Author(s):  
A.M. Lewandowski ◽  
T.M. Friedman ◽  
R. Korngold
Keyword(s):  
T Cell ◽  
Cd4 T Cell ◽  
Host Responses ◽  
Graft Versus Host ◽  
Graft Versus Leukemia ◽  
Graft Versus Leukemia Effect

The Allogeneic CD4+T-Cell-Mediated Graft-versus-Leukemia Effect

1997 ◽  
Vol 28 (1-2) ◽  
pp. 33-42 ◽  
Author(s):  
Yin-Zheng Jiang ◽  
John Barrett
Keyword(s):  
T Cell ◽  
Cd4 T Cell ◽  
Graft Versus Leukemia ◽  
Graft Versus Leukemia Effect

scholarly journals Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions

Blood ◽  
2006 ◽  
Vol 108 (6) ◽  
pp. 2106-2113 ◽  
Author(s):  
Ronjon Chakraverty ◽  
Hyeon-Seok Eom ◽  
Jessica Sachs ◽  
Jennifer Buchli ◽  
Pete Cotter ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Mhc Class Ii ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Cd4 T Cell ◽  
Graft Versus Host ◽  
Graft Versus Leukemia ◽  
T Cell Help ◽  
Antigen Presenting

Abstract Following bone marrow transplantation, delayed donor leukocyte infusions (DLIs) can induce graft-versus-leukemia (GVL) effects without graft-versus-host disease (GVHD). These antitumor responses are maximized by the presence of host hematopoietic antigen-presenting cells (APCs) at the time of DLI. Using a tumor-protection model, we demonstrate here that GVL activity following administration of DLIs to established mixed chimeras is dependent primarily on reactivity to allogeneic MHC antigens rather than minor histocompatibility or tumor-associated antigens. CD8+ T-cell–dependent GVL responses against an MHC class II–negative tumor following delayed DLI require CD4+ T-cell help and are reduced significantly when host APCs lack MHC class II expression. CD4+ T cells primed by host APCs were required for maximal expansion of graft-versus-host reactive CD8+ T cells but not their synthesis of IFN-γ. In contrast, the GVL requirement for CD4+ T-cell help was bypassed almost completely when DLI was administered to freshly irradiated recipients, indicating that the host environment is a major factor influencing the cellular mechanisms of GVL.

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