scholarly journals Long-term outcome after marrow transplantation from HLA-identical sibling donors for acquired aplastic anaemia using cyclophosphamide and in-vivo anti-CD52 monoclonal antibodies

2005 ◽  
Vol 11 (2) ◽  
pp. 34-35
Author(s):  
V. Gupta ◽  
S.E. Ball ◽  
Q.-L. Yi ◽  
D. Sage ◽  
S.R. McCann ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Aplastic Anaemia ◽  
Marrow Transplantation ◽  
Term Outcome ◽  
Long Term Outcome

Long-term outcome of Hurler syndrome following bone marrow transplantation

1993 ◽  
Vol 46 (2) ◽  
pp. 209-218 ◽  
Author(s):  
Chester B. Whitley ◽  
Kumar G. Belani ◽  
Pi-Nian Chang ◽  
C. Gail Summers ◽  
Bruce R. Blazar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Hurler Syndrome ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Long-Term Outcome After Marrow Transplantation for Severe Aplastic Anemia

Blood ◽  
1998 ◽  
Vol 91 (10) ◽  
pp. 3637-3645 ◽  
Author(s):  
H. Joachim Deeg ◽  
Wendy Leisenring ◽  
Rainer Storb ◽  
Janet Nims ◽  
Mary E.D. Flowers ◽  
...  
Keyword(s):  
Lung Disease ◽  
Aplastic Anemia ◽  
Marrow Transplantation ◽  
Chronic Gvhd ◽  
Psychosocial Health ◽  
Late Complications ◽  
Term Outcome ◽  
Long Term Outcome ◽  
The Status

Abstract We reviewed the records and reevaluated 212 patients with aplastic anemia transplanted at the Fred Hutchinson Cancer Research Center (FHCRC) between 1970 and 1993 who survived ≥2 years and who have been followed for up to 26 years. Parameters analyzed included hematopoietic function, chronic graft-versus-host disease (GVHD), skin disease, cataracts, lung disease, skeletal problems, posttransplant malignancy, depression, pregnancy/fatherhood, and the return to work or school, as well as patient self-assessment of physical and psychosocial health, social interactions, memory and concentration, and overall severity of symptoms. Survival probabilities at 20 years were 89% for patients without (n = 125) and 69% for patients with chronic GVHD (n = 86) (the status was uncertain in 1 surviving patient). All patients had normal hematopoietic parameters. Skin problems occurred in 14%, cataracts in 12%, lung disease in 24%, and bone and joint problems in 18% of patients. Eleven patients (12%) developed a solid tumor malignancy and 19% of patients experienced depression. Chronic GVHD was the dominant risk factor for late complications. Seventeen patients died at 2.5 to 20.4 years posttransplant; 13 of these had chronic GVHD and related complications. At 2 years, 83% of patients had returned to school or work; the proportion increased to 90% by 20 years. At least half of the patients preserved or regained the ability to become pregnant or father children. Patients rated their quality of life as excellent and symptoms as minimal or mild. In conclusion, marrow transplantation in patients with aplastic anemia established long-term normal hematopoiesis. No new hematologic disorders occurred. The major cause of morbidity and mortality was chronic GVHD. However, the majority of patients who survived beyond 2 years returned to a fully functional life.

scholarly journals Results of CoALL 07-03 study childhood ALL based on combined risk assessment by in vivo and in vitro pharmacosensitivity

2019 ◽  
Vol 3 (22) ◽  
pp. 3688-3699 ◽  
Author(s):  
Franziska Schramm ◽  
Udo zur Stadt ◽  
Martin Zimmermann ◽  
Norbert Jorch ◽  
Arnulf Pekrun ◽  
...  
Keyword(s):  
Drug Testing ◽  
Drug Response ◽  
Lymphoblastic Leukemia ◽  
Term Outcome ◽  
Childhood All ◽  
Long Term Outcome ◽  
Key Points

Key Points Report of the long-term outcome of children with acute lymphoblastic leukemia upon risk-adapted therapy accrued in trial CoALL 07-03. Lack of correlation between in vitro and in vivo drug response as well as a lower predictive value of in vitro drug testing.

scholarly journals Long-term outcome of adult acute leukemia patients who are alive and well 2 years after autologous blood or marrow transplantation

1999 ◽  
Vol 23 (9) ◽  
pp. 875-879 ◽  
Author(s):  
S Singhal ◽  
R Powles ◽  
J Treleaven ◽  
S Kulkarni ◽  
C Horton ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Marrow Transplantation ◽  
Autologous Blood ◽  
Term Outcome ◽  
Long Term Outcome
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