scholarly journals Aspergillus fumigatus-specific cytotoxic T-cell lines generated through use of Asp f16 protein-spanning pools of overlapping pentadecapeptides

2005 ◽  
Vol 11 (2) ◽  
pp. 15-16
Author(s):  
G. Ramadan ◽  
B. Davies ◽  
V.P. Kurup ◽  
C.A. Keever-Taylor
Keyword(s):  
T Cell ◽  
Aspergillus Fumigatus ◽  
Cell Lines ◽  
Cytotoxic T Cell ◽  
T Cell Lines ◽  
Cytotoxic T Cell Lines

Herpesvirus-transformed cytotoxic T-cell lines

Nature ◽  
1981 ◽  
Vol 291 (5810) ◽  
pp. 81-83 ◽  
Author(s):  
Donald R. Johnson ◽  
Mikael Jondal
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Cytotoxic T Cell ◽  
T Cell Lines ◽  
Cytotoxic T Cell Lines

Adoptive Transfer of Polyclonal, EBV-Specific Cytotoxic T-Cell Lines for the Prevention and Treatment of EBV-Associated Malignancies

Cell Therapy ◽  
2000 ◽  
pp. 45-60
Author(s):  
Cliona M. Rooney ◽  
M. Helen Huls ◽  
Richard A. Rochester ◽  
Malcolm K. Brenner ◽  
Helen E. Heslop
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Adoptive Transfer ◽  
Cytotoxic T Cell ◽  
Prevention And Treatment ◽  
T Cell Lines ◽  
Cytotoxic T Cell Lines

Two distinct phenotypes of HLA-DR-specific cytotoxic T-cell lines

1983 ◽  
Vol 17 (3) ◽  
pp. 317-324 ◽  
Author(s):  
Neal Flomenberg ◽  
Ellen Duffy ◽  
Kazuyuki Naito ◽  
Bo Dupont
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Cytotoxic T Cell ◽  
Hla Dr ◽  
T Cell Lines ◽  
Cytotoxic T Cell Lines

Ex vivo generation and expansion of anti-tumor cytotoxic T-cell lines derived from patients or their HLA-identical sibling

2004 ◽  
Vol 110 (1) ◽  
pp. 76-86 ◽  
Author(s):  
Daniela Montagna ◽  
Roberta Schiavo ◽  
Nadia Gibelli ◽  
Paolo Pedrazzoli ◽  
Roberto Tonelli ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Ex Vivo ◽  
Cytotoxic T Cell ◽  
T Cell Lines ◽  
Cytotoxic T Cell Lines

scholarly journals Identification of Hexon-Specific CD4 and CD8 T-Cell Epitopes for Vaccine and Immunotherapy

2007 ◽  
Vol 82 (1) ◽  
pp. 546-554 ◽  
Author(s):  
Ann M. Leen ◽  
Anne Christin ◽  
Mariam Khalil ◽  
Heidi Weiss ◽  
Adrian P. Gee ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Lines ◽  
Adoptive Transfer ◽  
Cytotoxic T Cell ◽  
Cell Immune Response ◽  
T Cell Epitopes ◽  
Human Pathogens ◽  
T Cell Lines ◽  
Cytotoxic T Cell Lines

ABSTRACT Adenoviral infections in the immunocompromised host are associated with significant morbidity and mortality. Although the adoptive transfer of adenovirus-specific T cells may prevent and treat such infections, the T-cell immune response to the multiplicity of adenovirus serotypes and subspecies that infect humans has not been well characterized, impeding the development of such approaches. We have, therefore, analyzed the specificities of T-cell responses to the viral capsid hexon antigen, since this structure is highly conserved in human pathogens. We screened 25 human cytotoxic T-cell lines with adenovirus specificity to extensively characterize their responses to adenoviral hexon and to identify a panel of novel CD4+ and CD8+ T-cell epitopes. Using a peptide library spanning the entire sequence of the hexon protein, we confirmed the responsiveness of these cytotoxic T-cell lines to seven peptides described previously and also identified 33 new CD4- or CD8-restricted hexon epitopes. Importantly, the majority of these epitopes were shared among different adenovirus subspecies, suggesting that T cells with such specificities could recognize and be protective against multiple serotypes, simplifying the task of effective adoptive transfer or vaccine-based immunotherapy for treating infection by this virus.

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