scholarly journals Assessing therapeutic response non-invasively in a neonatal rat model of acute inflammatory white matter injury using high-field MRI

2019 ◽  
Vol 81 ◽  
pp. 348-360 ◽  
Author(s):  
Wyston C. Pierre ◽  
Luis Akakpo ◽  
Irène Londono ◽  
Philippe Pouliot ◽  
Sylvain Chemtob ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Model ◽  
High Field ◽  
Therapeutic Response ◽  
White Matter Injury ◽  
Neonatal Rat ◽  
High Field Mri ◽  
Neonatal Rat Model

scholarly journals Characterization of White Matter Injury in a Hypoxic-Ischemic Neonatal Rat Model by Diffusion Tensor MRI

Stroke ◽  
2008 ◽  
Vol 39 (8) ◽  
pp. 2348-2353 ◽  
Author(s):  
Silun Wang ◽  
Ed X. Wu ◽  
Chung Nga Tam ◽  
Ho-Fai Lau ◽  
Pik-To Cheung ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Diffusion Tensor ◽  
White Matter Injury ◽  
Neonatal Rat ◽  
Diffusion Tensor Mri ◽  
Neonatal Rat Model

scholarly journals Pioglitazone Ameliorates Lipopolysaccharide-Induced Behavioral Impairment, Brain Inflammation, White Matter Injury and Mitochondrial Dysfunction in Neonatal Rats

2021 ◽  
Vol 22 (12) ◽  
pp. 6306
Author(s):  
Jiann-Horng Yeh ◽  
Kuo-Ching Wang ◽  
Asuka Kaizaki ◽  
Jonathan W. Lee ◽  
Han-Chi Wei ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
White Matter ◽  
Brain Inflammation ◽  
White Matter Injury ◽  
Neonatal Rat ◽  
Mitochondrial Activity ◽  
Neonatal Rats ◽  
Activated Microglia ◽  
Brain White Matter ◽  
Performance Reduction

Previous studies have demonstrated that pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, inhibits ischemia-induced brain injury. The present study was conducted to examine whether pioglitazone can reduce impairment of behavioral deficits mediated by inflammatory-induced brain white matter injury in neonatal rats. Intraperitoneal (i.p.) injection of lipopolysaccharide (LPS, 2 mg/kg) was administered to Sprague–Dawley rat pups on postnatal day 5 (P5), and i.p. administration of pioglitazone (20 mg/kg) or vehicle was performed 5 min after LPS injection. Sensorimotor behavioral tests were performed 24 h after LPS exposure, and changes in biochemistry of the brain was examined after these tests. The results show that systemic LPS exposure resulted in impaired sensorimotor behavioral performance, reduction of oligodendrocytes and mitochondrial activity, and increases in lipid peroxidation and brain inflammation, as indicated by the increment of interleukin-1β (IL-1β) levels and number of activated microglia in the neonatal rat brain. Pioglitazone treatment significantly improved LPS-induced neurobehavioral and physiological disturbances including the loss of body weight, hypothermia, righting reflex, wire-hanging maneuver, negative geotaxis, and hind-limb suspension in neonatal rats. The neuroprotective effect of pioglitazone against the loss of oligodendrocytes and mitochondrial activity was associated with attenuation of LPS-induced increment of thiobarbituric acid reactive substances (TBARS) content, IL-1β levels and number of activated microglia in neonatal rats. Our results show that pioglitazone prevents neurobehavioral disturbances induced by systemic LPS exposure in neonatal rats, and its neuroprotective effects are associated with its impact on microglial activation, IL-1β induction, lipid peroxidation, oligodendrocyte production and mitochondrial activity.

scholarly journals Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis

2012 ◽  
Vol 47 (9) ◽  
pp. 1652-1657 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Sadık Yurttutan ◽  
Fatma Nur Sarı ◽  
Bulent Uysal ◽  
Hatice Germen Unverdi ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Antioxidant Effects ◽  
Neonatal Rat Model

scholarly journals Renal Glomeruli and Tubular Injury Following Indomethacin, Ibuprofen, and Gentamicin Exposure in a Neonatal Rat Model

2007 ◽  
Vol 62 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Alison L Kent ◽  
Lesley E Maxwell ◽  
Mark E Koina ◽  
Michael C Falk ◽  
David Willenborg ◽  
...  
Keyword(s):  
Rat Model ◽  
Neonatal Rat ◽  
Tubular Injury ◽  
Renal Glomeruli ◽  
Neonatal Rat Model

Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model

2002 ◽  
Vol 282 (1) ◽  
pp. G156-G164 ◽  
Author(s):  
Bohuslav Dvorak ◽  
Melissa D. Halpern ◽  
Hana Holubec ◽  
Catherine S. Williams ◽  
Debra L. McWilliam ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mrna Expression ◽  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Gastrointestinal Disease ◽  
Neonatal Rat ◽  
Epidermal Growth ◽  
Neonatal Rat Model

Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of prematurely born infants. Maternal milk plays an important protective role against NEC development and is the major source of epidermal growth factor (EGF) for neonates. The aim of this study was to examine the effect of orally administered EGF on the incidence of NEC in a neonatal rat model. Newborn rats were artificially fed either with growth factor-free rat milk substitute (RMS) or RMS supplemented with 500 ng/ml of EGF (RMS+EGF). Experimental NEC was induced by exposure to asphyxia and cold stress. Development of NEC was evaluated by gross and histological scoring of damage in the ileum. Ileal EGF receptor (EGF-R), EGF, and transforming growth factor-α mRNA expression was assessed by RT competitive-PCR, and the EGF-R was localized by immunohistochemistry. EGF supplementation of formula reduced the incidence and severity of NEC in rats (13/16 RMS vs. 4/13 RMS+EGF). Ileal EGF-R mRNA expression was markedly increased in the RMS group compared with RMS+EGF. Enhanced EGF-R expression in the RMS group was localized predominantly in the epithelial cells of injured ileum. These data suggest a new potential therapeutic approach for the prevention and treatment of NEC.

ISDN2014_0189: Sulforaphane is not additive in combination with hypothermia in a neonatal rat model of hypoxia–ischemia

2015 ◽  
Vol 47 (Part_A) ◽  
pp. 55-55 ◽  
Author(s):  
Ann‐Marie Przyslupski ◽  
Edward Armstrong ◽  
Keqin Shen ◽  
Jerome Y. Yager
Keyword(s):  
Rat Model ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Model
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