Placental growth factor-1 (PlGF-1) is related to vascularization, DHEAS to DHEA conversion, and aromatase expression in patients with arthritis—A placental role of PlGF-1 in the synovium

2006 ◽  
Vol 20 (3) ◽  
pp. 8
Author(s):  
Silvia Capellino ◽  
Claudia Weidler ◽  
Sven Anders ◽  
Christoph G. Baerwald ◽  
Frank Buttgereit ◽  
...  
Keyword(s):  
Growth Factor ◽  
Placental Growth Factor ◽  
Aromatase Expression

The role of placental growth factor in regulating fetal brain vascular development

2014 ◽  
Author(s):  
Matthew T Ratsep ◽  
Bruno Zavan ◽  
Nicki Peterson ◽  
Leandra Tolusso ◽  
Vanessa Kay ◽  
...  
Keyword(s):  
Growth Factor ◽  
Vascular Development ◽  
Fetal Brain ◽  
Placental Growth Factor

scholarly journals Mechanistic and pharmacologic role of placental growth factor in experimental ulcerative colitis in rats

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Xiaoming Deng ◽  
Ximing Xiong ◽  
Tetyana Khomenko ◽  
Longchuan Chen ◽  
Sandor Szabo ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Growth Factor ◽  
Placental Growth Factor ◽  
Experimental Ulcerative Colitis

The Role Of Placental Growth Factor In Hypoxia Induced Angiogenesis In The Adult Mouse Lung

2011 ◽  
Author(s):  
Elaine Colfer ◽  
Christine M. Costello ◽  
Sandro De Falco ◽  
Paul McLoughlin ◽  
Katherine Howell
Keyword(s):  
Growth Factor ◽  
Adult Mouse ◽  
Placental Growth Factor ◽  
Mouse Lung

531 THE ROLE OF PLACENTAL GROWTH FACTOR AND ITS RECEPTOR IN LIVER REGENERATION AFTER PARTIAL HEPATECTOMY

2008 ◽  
Vol 48 ◽  
pp. S199-S200
Author(s):  
E. Vanheule ◽  
Y.-D. Fan ◽  
J. Van Huysse ◽  
D. Meester ◽  
M. Praet ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Placental Growth Factor

scholarly journals Selected Aspects of Angiogensis in Haematological Malignancies

2011 ◽  
Vol 3 (2) ◽  
pp. 17-39
Author(s):  
Patrycja Sujka-Kordowska ◽  
Agnieszka Malińska ◽  
Maciej Zabel
Keyword(s):  
Bone Marrow ◽  
Growth Factor ◽  
Microvessel Density ◽  
Antiangiogenic Therapy ◽  
Lymphoproliferative Disorders ◽  
Placental Growth Factor ◽  
Haematological Malignancies ◽  
Cyclooxygenase 1 ◽  
Haematological Disorders

SummaryIt is well established that angiogenesis is necessary in solid tumours development. Interesingly, the role of angiogensis in haematological malignancies has been also recognized. Recent publicationts indicate that microvessel density in bone marrow and angiogenic factors like endoglin, placental growth factor and cyclooxygenase 1 are increased in lymphoproliferative disorders and suggest that angiogensis is a part of pathomechanism of these malignancies. However, it has not been identified how angiogenesis can be involved in progression of haematological disorders. There is a strong need for further investigations in this area, since antiangiogenic therapy is a potential adjunct to conventional therapy of lymphoproliferative disorders.

Role of angiopoietin-2, endoglin, and placental growth factor in HIV-associated preeclampsia

2017 ◽  
Vol 36 (3) ◽  
pp. 240-246 ◽  
Author(s):  
Nokuzola Mbhele ◽  
Jagidesa Moodley ◽  
Thajasvarie Naicker
Keyword(s):  
Growth Factor ◽  
Placental Growth Factor ◽  
Angiopoietin 2

Evidence for a protective role of placental growth factor in cardiovascular disease

2020 ◽  
Vol 12 (572) ◽  
pp. eabc8587
Author(s):  
Yihong Chen ◽  
Anna Hultgårdh Nilsson ◽  
Isabel Goncalves ◽  
Andreas Edsfeldt ◽  
Gunnar Engström ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Cardiovascular Risk ◽  
Growth Factor ◽  
Lower Risk ◽  
Protective Role ◽  
Placental Growth Factor ◽  
Trail Receptor ◽  
Population Cohort

Placental growth factor (PlGF) is a mitogen for endothelial cells, but it can also act as a proinflammatory cytokine. Because it promotes early stages of plaque formation in experimental models of atherosclerosis and was implicated in epidemiological associations with risk of cardiovascular disease (CVD), PlGF has been attributed a pro-atherogenic role. Here, we investigated whether PlGF has a protective role in CVD and whether elevated PlGF reflects activation of repair processes in response to vascular stress. In a population cohort of 4742 individuals with 20 years of follow-up, high baseline plasma PlGF was associated with increased risk of cardiovascular death, myocardial infarction, and stroke, but these associations were lost or weakened when adjusting for cardiovascular risk factors known to cause vascular stress. Exposure of cultured endothelial cells to high glucose, oxidized low-density lipoprotein (LDL) or an inducer of apoptosis enhanced the release of PlGF. Smooth muscle cells and endothelial cells treated with PlGF small interference RNA demonstrated that autocrine PlGF stimulation plays an important role in vascular repair responses. High expression of PlGF in human carotid plaques removed at surgery was associated with a more stable plaque phenotype and a lower risk of future cardiovascular events. When adjusting associations of PlGF with cardiovascular risk in the population cohort for plasma soluble tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) receptor-2, a biomarker of cellular stress, a high PlGF/TRAIL receptor-2 ratio was associated with a lower risk. Our findings provide evidence for a protective role of PlGF in CVD.

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