The importance of being (slightly) modified: The role of rRNA editing on gene expression control and its connections with cancer

2016 ◽  
Vol 1866 (2) ◽  
pp. 330-338 ◽  
Author(s):  
Marianna Penzo ◽  
Alice Galbiati ◽  
Davide Treré ◽  
Lorenzo Montanaro
Keyword(s):  
Gene Expression ◽  
Expression Control ◽  
Gene Expression Control

The Role of the Epigenome in Gene Expression Control and the Epimark Changes in Response to the Environment

2014 ◽  
Vol 33 (1) ◽  
pp. 64-87 ◽  
Author(s):  
Michael J. Van Oosten ◽  
Ray A. Bressan ◽  
Jian-Kang Zhu ◽  
Hans J. Bohnert ◽  
Viswanathan Chinnusamy
Keyword(s):  
Gene Expression ◽  
Expression Control ◽  
Gene Expression Control

scholarly journals High-performance chemical- and light-inducible recombinases in mammalian cells and mice

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Benjamin H. Weinberg ◽  
Jang Hwan Cho ◽  
Yash Agarwal ◽  
N. T. Hang Pham ◽  
Leidy D. Caraballo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mammalian Cells ◽  
High Performance ◽  
Genome Engineering ◽  
Genetic Circuits ◽  
Control Of Gene Expression ◽  
Expression Control ◽  
Gene Expression Control ◽  
High Performance Systems ◽  
Spatiotemporal Control

Abstract Site-specific DNA recombinases are important genome engineering tools. Chemical- and light-inducible recombinases, in particular, enable spatiotemporal control of gene expression. However, inducible recombinases are scarce due to the challenge of engineering high performance systems, thus constraining the sophistication of genetic circuits and animal models that can be created. Here we present a library of >20 orthogonal inducible split recombinases that can be activated by small molecules, light and temperature in mammalian cells and mice. Furthermore, we engineer inducible split Cre systems with better performance than existing systems. Using our orthogonal inducible recombinases, we create a genetic switchboard that can independently regulate the expression of 3 different cytokines in the same cell, a tripartite inducible Flp, and a 4-input AND gate. We quantitatively characterize the inducible recombinases for benchmarking their performances, including computation of distinguishability of outputs. This library expands capabilities for multiplexed mammalian gene expression control.

scholarly journals Global quantification of mammalian gene expression control

Nature ◽  
2011 ◽  
Vol 473 (7347) ◽  
pp. 337-342 ◽  
Author(s):  
Björn Schwanhäusser ◽  
Dorothea Busse ◽  
Na Li ◽  
Gunnar Dittmar ◽  
Johannes Schuchhardt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mammalian Gene ◽  
Expression Control ◽  
Gene Expression Control ◽  
Mammalian Gene Expression

The ins and outs of gene expression control

2004 ◽  
Vol 22 (7) ◽  
pp. 824-826 ◽  
Author(s):  
Francine B Perler
Keyword(s):  
Gene Expression ◽  
Expression Control ◽  
Gene Expression Control
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