Role of somatic cancer mutations in human protein lysine methyltransferases

2014 ◽  
Vol 1846 (2) ◽  
pp. 366-379 ◽  
Author(s):  
Srikanth Kudithipudi ◽  
Albert Jeltsch
Keyword(s):  
Human Protein ◽  
Cancer Mutations ◽  
Lysine Methyltransferases

Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation

2013 ◽  
Vol 16 (1) ◽  
pp. 70-82 ◽  
Author(s):  
Anastasia Spyropoulou ◽  
Antonios Gargalionis ◽  
Georgia Dalagiorgou ◽  
Christos Adamopoulos ◽  
Kostas A. Papavassiliou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Colony Formation ◽  
Histone Lysine ◽  
Lysine Methyltransferases ◽  
Histone Lysine Methyltransferases

scholarly journals Role of several histone lysine methyltransferases in tumor development

2016 ◽  
Vol 4 (3) ◽  
pp. 293-299 ◽  
Author(s):  
JIFU LI ◽  
SHUNQIN ZHU ◽  
XIAO-XUE KE ◽  
HONGJUAN CUI
Keyword(s):  
Tumor Development ◽  
Histone Lysine ◽  
Lysine Methyltransferases ◽  
Histone Lysine Methyltransferases

scholarly journals Expression of Human Protein Phosphatase-1 inSaccharomyces cerevisiaeHighlights the Role of Phosphatase Isoforms in Regulating Eukaryotic Functions

2007 ◽  
Vol 282 (30) ◽  
pp. 21838-21847 ◽  
Author(s):  
Jennifer A. Gibbons ◽  
Lukasz Kozubowski ◽  
Kelly Tatchell ◽  
Shirish Shenolikar
Keyword(s):  
Protein Phosphatase ◽  
Human Protein ◽  
Protein Phosphatase 1

scholarly journals Screening for mutations in BRCA1 and BRCA2 genes and related perspectives for the healthcare system

2021 ◽  
Vol 18 (1-2) ◽  
pp. 44-57
Author(s):  
Y. O. Tabaliuk ◽  
L. A. Rybchenko ◽  
B. T. Klimuk ◽  
S. V. Klymenko
Keyword(s):  
Ovarian Cancer ◽  
Genetic Test ◽  
Breast And Ovarian Cancer ◽  
Brca1 And Brca2 ◽  
Brca1 And Brca2 Genes ◽  
Prevention And Treatment ◽  
Cancer Mutations ◽  
Brca1 Brca2 ◽  
Detection Of Mutations

In the article there were looked some aspects of the knowledge regarding mutations in BRCA1 BRCA2 genes that have been accumulated since the first report on role of these genes in the development of breast and ovarian cancer. Most of them have practical worth related to the detection of mutations, as well as the prevention and treatment of associated ovarian cancer (the article focuses specifically on ovarian cancer, conditioned to relatively less amount of information on this pathology). There has been paid attention to the rational assignment of a genetic test on the presence of mutations in BRCA genes.Keywords: ovarian cancer, mutations in BRCA1 BRCA2 genes, screening of the presence mutations in BRCA1 BRCA2 genes.

Elevation of Intracellular dNTP Levels: A Mechanistic Role of SAMHD1 Cancer Mutations

2021 ◽  
Author(s):  
Nicole E. Bowen ◽  
Joshua Temple ◽  
Caitlin Shepard ◽  
Adrian Oo ◽  
Fidel Arizaga ◽  
...  
Keyword(s):  
Intracellular Dntp ◽  
Cancer Mutations

scholarly journals Exploring the Role of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma through the Mining of the Human Protein Atlas

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 640
Author(s):  
Nataša Pavlović ◽  
Femke Heindryckx
Keyword(s):  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Predictive Biomarkers ◽  
Human Protein ◽  
Disease Stage ◽  
Unfolded Protein ◽  
Human Protein Atlas ◽  
Associated Proteins ◽  
Protein Response

Endoplasmic reticulum (ER) stress and actors of unfolded protein response (UPR) have emerged as key hallmarks of hepatocarcinogenesis. Numerous reports have shown that the main actors in the UPR pathways are upregulated in HCC and contribute to the different facets of tumor initiation and disease progression. Furthermore, ER-stress inducers and inhibitors have shown success in preclinical HCC models. Despite the mounting evidence of the UPR’s involvement in HCC pathogenesis, it remains unclear how ER-stress components can be used safely and effectively as therapeutic targets or predictive biomarkers for HCC patients. In an effort to add a clinical context to these findings and explore the translational potential of ER-stress in HCC, we performed a systematic overview of UPR-associated proteins as predictive biomarkers in HCC by mining the Human Protein Atlas database. Aside from evaluating the prognostic value of these markers in HCC, we discussed their expression in relation to patient age, sex, ethnicity, disease stage, and tissue localization. We thereby identified 44 UPR-associated proteins as unfavorable prognostic markers in HCC. The expression of these markers was found to be higher in tumors compared to the stroma of the hepatic HCC patient tissues.

Sign in / Sign up

Export Citation Format

Share Document