scholarly journals COX-derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention

2012 ◽  
Vol 1825 (1) ◽  
pp. 49-63 ◽  
Author(s):  
Mary-Clare Cathcart ◽  
Kenneth J. O'Byrne ◽  
John V. Reynolds ◽  
Jacintha O'Sullivan ◽  
Graham P. Pidgeon
Keyword(s):  
Gastrointestinal Cancer ◽  
Cancer Development ◽  
Prevention And Intervention ◽  
Novel Targets

Involvement of bone marrow-derived stromal cells in gastrointestinal cancer development and metastasis

2008 ◽  
Vol 23 ◽  
pp. S242-S249 ◽  
Author(s):  
Shuji Ishii ◽  
Shingo Tsuji ◽  
Masahiko Tsujii ◽  
Yoshiyuki Kanazawa ◽  
Tsutomu Nishida ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Gastrointestinal Cancer ◽  
Cancer Development

Angiogenesis in cancer

2012 ◽  
Vol 03 (04) ◽  
pp. 149-158
Author(s):  
M. Poettler ◽  
G. W. Prager
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Therapeutic Interventions ◽  
Cancer Development ◽  
Vascular Endothelial ◽  
Malignant Growth ◽  
Pharmacological Agents ◽  
Limited Efficacy ◽  
Novel Targets ◽  
Endothelial Growth Factor

SummaryEtiological concepts on cancer development, malignant growth and tumour propagation have undergone a revolutionary development during recent years: Among other aspects, the discovery of angiogenesis - the growth of new blood vessels from pre-existing vasculature - as a key element in the pathogenesis of malignancy has opened an abundance of biologic insights and subsequent therapeutic options, which have led to improved prognosis in many cancers including those originating from colon, lung, breast and kidney. Thereby, targeting the major pro-angiogenic stimulus vascular endothelial growth factor (VEGF) became the focus for therapeutic interventions. However, the use of VEGF-targeting drugs has been shown to be of limited efficacy, which might lie in the fact that tumor angiogenesis is mediated by a variety of different subcellular systems.This review focuses on the basic mechanisms involved in angiogenesis, which potentially represent novel targets for pharmacological agents in the treatment of malignancies.

Angiogenesis in cancer

2012 ◽  
Vol 32 (02) ◽  
pp. 105-114 ◽  
Author(s):  
M. Poettler ◽  
G. W. Prager
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Therapeutic Interventions ◽  
Cancer Development ◽  
Vascular Endothelial ◽  
Malignant Growth ◽  
Pharmacological Agents ◽  
Limited Efficacy ◽  
Novel Targets ◽  
Endothelial Growth Factor

SummaryEtiological concepts on cancer development, malignant growth and tumour propagation have undergone a revolutionary development during recent years: Among other aspects, the discovery of angiogenesis – the growth of new blood vessels from pre-existing vasculature – as a key element in the pathogenesis of malignancy has opened an abundance of biologic insights and subsequent therapeutic options, which have led to improved prognosis in many cancers including those originating from colon, lung, breast and kidney. Thereby, targeting the major pro-angiogenic stimulus vascular endothelial growth factor (VEGF) became the focus for therapeutic interventions. However, the use of VEGF-targeting drugs has been shown to be of limited efficacy, which might lie in the fact that tumor angiogenesis is mediated by a variety of different subcellular systems.This review focuses on the basic mechanisms involved in angiogenesis, which potentially represent novel targets for pharmacological agents in the treatment of malignancies.

scholarly journals F-Box Proteins and Cancer

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1249 ◽  
Author(s):  
Kanae Yumimoto ◽  
Yuhei Yamauchi ◽  
Keiichi I. Nakayama
Keyword(s):  
Ubiquitin Ligase ◽  
Molecular Basis ◽  
Cancer Therapeutics ◽  
S Phase ◽  
Cancer Development ◽  
Tumor Promoters ◽  
Cellular Processes ◽  
Novel Targets ◽  
Scf Ubiquitin Ligase ◽  
F Box Protein

Controlled protein degradation is essential for the operation of a variety of cellular processes including cell division, growth, and differentiation. Identification of the relations between ubiquitin ligases and their substrates is key to understanding the molecular basis of cancer development and to the discovery of novel targets for cancer therapeutics. F-box proteins function as the substrate recognition subunits of S-phase kinase-associated protein 1 (SKP1)−Cullin1 (CUL1)−F-box protein (SCF) ubiquitin ligase complexes. Here, we summarize the roles of specific F-box proteins that have been shown to function as tumor promoters or suppressors. We also highlight proto-oncoproteins that are targeted for ubiquitylation by multiple F-box proteins, and discuss how these F-box proteins are deployed to regulate their cognate substrates in various situations.

Abstract 987: NGF promotes gastrointestinal cancer development through tumor-associated neurogenesis

2015 ◽  
Author(s):  
Yoku Hayakawa ◽  
Samuel Asfaha ◽  
Bernhard W. Renz ◽  
Christoph B. Westphalen ◽  
Yagnesh Tailor ◽  
...  
Keyword(s):  
Gastrointestinal Cancer ◽  
Cancer Development

scholarly journals Exploring the Mechanisms of Gastrointestinal Cancer Development Using Deep Sequencing Analysis

Cancers ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 1037-1051 ◽  
Author(s):  
Tomonori Matsumoto ◽  
Takahiro Shimizu ◽  
Atsushi Takai ◽  
Hiroyuki Marusawa
Keyword(s):  
Deep Sequencing ◽  
Gastrointestinal Cancer ◽  
Cancer Development ◽  
Sequencing Analysis ◽  
Deep Sequencing Analysis
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