scholarly journals Current status of molecular markers for early detection of sporadic pancreatic cancer

2011 ◽  
Vol 1815 (1) ◽  
pp. 44-64 ◽  
Author(s):  
Subhankar Chakraborty ◽  
Michael J. Baine ◽  
Aaron R. Sasson ◽  
Surinder K. Batra
Keyword(s):  
Pancreatic Cancer ◽  
Molecular Markers ◽  
Early Detection ◽  
Current Status ◽  
Sporadic Pancreatic Cancer

Early detection of sporadic pancreatic cancer

2017 ◽  
Vol 29 (8) ◽  
pp. 885-891 ◽  
Author(s):  
Přemysl Frič ◽  
Aleksi Šedo ◽  
Jan Škrha ◽  
Petr Bušek ◽  
Martin Laclav ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Sporadic Pancreatic Cancer

scholarly journals Early Detection of Sporadic Pancreatic Cancer

Pancreas ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 686-692 ◽  
Author(s):  
Barbara J. Kenner ◽  
Suresh T. Chari ◽  
Deborah F. Cleeter ◽  
Vay Liang W. Go
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Sporadic Pancreatic Cancer

scholarly journals Early Detection of Sporadic Pancreatic Cancer

Pancreas ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 693-712 ◽  
Author(s):  
Suresh T. Chari ◽  
Kimberly Kelly ◽  
Michael A. Hollingsworth ◽  
Sarah P. Thayer ◽  
David A. Ahlquist ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Sporadic Pancreatic Cancer

scholarly journals Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
M. Distler ◽  
D. Aust ◽  
J. Weitz ◽  
C. Pilarsky ◽  
Robert Grützmann
Keyword(s):  
Pancreatic Cancer ◽  
Mortality Rate ◽  
Early Detection ◽  
Current Level ◽  
Diagnostic Tools ◽  
Precursor Lesions ◽  
Highly Sensitive ◽  
Level Of Knowledge ◽  
Clinical Measures ◽  
Sporadic Pancreatic Cancer

Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. The early detection of these lesions is still challenging but provides the chance to cure patients before they might get an invasive pancreatic carcinoma. This paper focuses on PanIN, IPMN, and MCN lesions and reviews the current level of knowledge and clinical measures.

scholarly journals Blood biomarkers for differential diagnosis and early detection of pancreatic cancer

2021 ◽  
pp. 102193
Author(s):  
Fawaz N. Al-Shaheri ◽  
Mohamed S.S. Alhamdani ◽  
Andrea Bauer ◽  
Nathalia Giese ◽  
Markus W. Büchler ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Differential Diagnosis ◽  
Early Detection ◽  
Blood Biomarkers

scholarly journals Pancreatic Cancer Exposome Profile to Aid Early Detection and Inform Prevention Strategies

2021 ◽  
Vol 10 (8) ◽  
pp. 1665
Author(s):  
Maria J. Monroy-Iglesias ◽  
Saoirse Dolly ◽  
Debashis Sarker ◽  
Kiruthikah Thillai ◽  
Mieke Van Hemelrijck ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Immune Responses ◽  
Inflammatory Markers ◽  
Poor Prognosis ◽  
Associated Factors ◽  
Review Of The Literature ◽  
Prevention Strategies ◽  
Factors Influencing ◽  
Detection Strategies

Pancreatic cancer (PCa) is associated with a poor prognosis and high mortality rate. The causes of PCa are not fully elucidated yet, although certain exposome factors have been identified. The exposome is defined as the sum of all environmental factors influencing the occurrence of a disease during a life span. The development of an exposome approach for PCa has the potential to discover new disease-associated factors to better understand the carcinogenesis of PCa and help with early detection strategies. Our systematic review of the literature identified several exposome factors that have been associated with PCa alone and in combination with other exposures. A potential inflammatory signature has been observed among the interaction of several exposures (i.e., smoking, alcohol consumption, diabetes mellitus, obesity, and inflammatory markers) that further increases the incidence and progression of PCa. A large number of exposures have been identified such as genetic, hormonal, microorganism infections and immune responses that warrant further investigation. Future early detection strategies should utilize this information to assess individuals’ risk for PCa.

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