The role of tyrosine 177 in human 11β-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate

2006 ◽  
Vol 1764 (4) ◽  
pp. 824-830 ◽  
Author(s):  
Ki Won Kim ◽  
Zhulun Wang ◽  
James Busby ◽  
Trace Tsuruda ◽  
Michelle Chen ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Hydroxysteroid Dehydrogenase ◽  
Hydrogen Bond Donor ◽  
Inhibitor Binding

The role of hepatic 11[b]-hydroxysteroid dehydrogenase type 1 in cholesterol homeostasis

2013 ◽  
pp. 1-1
Author(s):  
Kajal Manwani ◽  
Tak Y Man ◽  
Christopher J Kenyon ◽  
Ruth Andrew ◽  
Karen E Chapman ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Cholesterol Homeostasis

Role of the hydrogen bond donor component for a proper development of novel hydrophobic deep eutectic solvents

2019 ◽  
Vol 281 ◽  
pp. 423-430 ◽  
Author(s):  
Matteo Tiecco ◽  
Federico Cappellini ◽  
Francesco Nicoletti ◽  
Tiziana Del Giacco ◽  
Raimondo Germani ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Donor

Role of 17β-hydroxysteroid dehydrogenase type 1 in endocrine and intracrine estradiol biosynthesis

1995 ◽  
Vol 55 (5-6) ◽  
pp. 525-532 ◽  
Author(s):  
Matti Poutanen ◽  
Veli Isomaa ◽  
Hellevi Peltoketo ◽  
Reijo Vihko
Keyword(s):  
Hydroxysteroid Dehydrogenase

Bicyclic Substituted Hydroxyphenylmethanone Type Inhibitors of 17 β-Hydroxysteroid Dehydrogenase Type 1 (17 β-HSD1): The Role of the Bicyclic Moiety

ChemMedChem ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. 476-487 ◽  
Author(s):  
Alexander Oster ◽  
Tobias Klein ◽  
Claudia Henn ◽  
Ruth Werth ◽  
Sandrine Marchais-Oberwinkler ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase

scholarly journals Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium

2017 ◽  
Vol 58 (1) ◽  
pp. R1-R13 ◽  
Author(s):  
Gillian A Gray ◽  
Christopher I White ◽  
Raphael F P Castellan ◽  
Sara J McSweeney ◽  
Karen E Chapman
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Systemic Corticosteroid ◽  
Physiological Function ◽  
Pressure Overload ◽  
Hydroxysteroid Dehydrogenase ◽  
And Function ◽  
Glucocorticoid Metabolism

Corticosteroids influence the development and function of the heart and its response to injury and pressure overload via actions on glucocorticoid (GR) and mineralocorticoid (MR) receptors. Systemic corticosteroid concentration depends largely on the activity of the hypothalamic–pituitary–adrenal (HPA) axis, but glucocorticoid can also be regenerated from intrinsically inert metabolites by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), selectively increasing glucocorticoid levels within cells and tissues. Extensive studies have revealed the roles for glucocorticoid regeneration by 11β-HSD1 in liver, adipose, brain and other tissues, but until recently, there has been little focus on the heart. This article reviews the evidence for glucocorticoid metabolism by 11β-HSD1 in the heart and for a role of 11β-HSD1 activity in determining the myocardial growth and physiological function. We also consider the potential of 11β-HSD1 as a therapeutic target to enhance repair after myocardial infarction and to prevent the development of cardiac remodelling and heart failure.

Dual Role of the 1,2,3-Triazolium Ring as a Hydrogen-Bond Donor and Anion-π Receptor in Anion-Recognition Processes

2015 ◽  
Vol 21 (27) ◽  
pp. 9797-9808 ◽  
Author(s):  
Fabiola Zapata ◽  
Lidia Gonzalez ◽  
Antonio Caballero ◽  
Ibón Alkorta ◽  
Jose Elguero ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Anion Recognition ◽  
Dual Role ◽  
Hydrogen Bond Donor
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