Computational modelling of the open-state Kv1.5 ion channel block by bupivacaine

2003 ◽  
Vol 1652 (1) ◽  
pp. 35-51 ◽  
Author(s):  
Victor B Luzhkov ◽  
Johanna Nilsson ◽  
Peter Århem ◽  
Johan Åqvist
Keyword(s):  
Ion Channel ◽  
Computational Modelling ◽  
Channel Block

scholarly journals Assessment of Multi‐Ion Channel Block in a Phase I Randomized Study Design: Results of the Ci PA Phase I ECG Biomarker Validation Study

2019 ◽  
Vol 105 (4) ◽  
pp. 943-953 ◽  
Author(s):  
Jose Vicente ◽  
Robbert Zusterzeel ◽  
Lars Johannesen ◽  
Roberto Ochoa‐Jimenez ◽  
Jay W. Mason ◽  
...  
Keyword(s):  
Phase I ◽  
Ion Channel ◽  
Study Design ◽  
Validation Study ◽  
Randomized Study ◽  
Channel Block ◽  
Biomarker Validation

scholarly journals Arrhythmic hazard map for a 3D whole-ventricle model under multiple ion channel block

2018 ◽  
Vol 175 (17) ◽  
pp. 3435-3452 ◽  
Author(s):  
Jun-ichi Okada ◽  
Takashi Yoshinaga ◽  
Junko Kurokawa ◽  
Takumi Washio ◽  
Tetsushi Furukawa ◽  
...  
Keyword(s):  
Ion Channel ◽  
Hazard Map ◽  
Channel Block

Computational Modelling of Optogenetics in Cardiac Cells

2012 ◽  
Author(s):  
Jonathan Wong ◽  
Oscar Abilez ◽  
Ellen Kuhl
Keyword(s):  
Finite Element ◽  
Ion Channel ◽  
Single Cell ◽  
Cardiac Myocytes ◽  
Cardiac Tissue ◽  
Channel Model ◽  
Computational Modelling ◽  
Cardiac Cells ◽  
Cardiac Cell ◽  
Cell Models

Channelrhodopsin-2 (ChR2) is a light-activated ion channel that can allow scientists to electrically activate cells via optical stimulation. Using a combination of existing computational electrophysiological and mechanical cardiac cell models with a novel ChR2 ion channel model, we created a model for ChR2-transduced cardiac myocytes. We implemented this model into a commonly available finite element platform and simulated both the single cell and the tissue electromechanical response. Our simulations show that it is possible to stimulate cardiac tissue optically with ChR2-transduced cells.

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

2010 ◽  
Vol 17 (11) ◽  
pp. 1330-1336 ◽  
Author(s):  
Ricarda J C Hilf ◽  
Carlo Bertozzi ◽  
Iwan Zimmermann ◽  
Alwin Reiter ◽  
Dirk Trauner ◽  
...  
Keyword(s):  
Ion Channel ◽  
Open Channel ◽  
Structural Basis ◽  
Channel Block ◽  
Open Channel Block

A new type of ion-channel block

Nature ◽  
1987 ◽  
Vol 329 (6136) ◽  
pp. 204-205 ◽  
Author(s):  
David Colquhoun
Keyword(s):  
Ion Channel ◽  
Channel Block ◽  
New Type

scholarly journals Understanding AF Mechanisms Through Computational Modelling and Simulations

2019 ◽  
Vol 8 (3) ◽  
pp. 210-219 ◽  
Author(s):  
Konstantinos N Aronis ◽  
Rheeda L Ali ◽  
Jialiu A Liang ◽  
Shijie Zhou ◽  
Natalia A Trayanova
Keyword(s):  
Adipose Tissue ◽  
Ion Channel ◽  
Pulmonary Vein ◽  
Progressive Disease ◽  
Computational Modelling ◽  
Clinical Findings ◽  
Future Perspectives ◽  
Atrial Fibrosis ◽  
Atrial Wall ◽  
Multi Scale

AF is a progressive disease of the atria, involving complex mechanisms related to its initiation, maintenance and progression. Computational modelling provides a framework for integration of experimental and clinical findings, and has emerged as an essential part of mechanistic research in AF. The authors summarise recent advancements in development of multi-scale AF models and focus on the mechanistic links between alternations in atrial structure and electrophysiology with AF. Key AF mechanisms that have been explored using atrial modelling are pulmonary vein ectopy; atrial fibrosis and fibrosis distribution; atrial wall thickness heterogeneity; atrial adipose tissue infiltration; development of repolarisation alternans; cardiac ion channel mutations; and atrial stretch with mechano-electrical feedback. They review modelling approaches that capture variability at the cohort level and provide cohort-specific mechanistic insights. The authors conclude with a summary of future perspectives, as envisioned for the contributions of atrial modelling in the mechanistic understanding of AF.

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