scholarly journals Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: Relating plasma circulation lifetimes to protein binding

2007 ◽  
Vol 1768 (6) ◽  
pp. 1367-1377 ◽  
Author(s):  
Nancy Dos Santos ◽  
Christine Allen ◽  
Anne-Marie Doppen ◽  
Malathi Anantha ◽  
Kelly A.K. Cox ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Protein Binding ◽  
Poly Ethylene Glycol ◽  
Grafting Density ◽  
Poly Ethylene

scholarly journals Tailoring Nanocellulose–Cellulose Triacetate Interfaces by Varying the Surface Grafting Density of Poly(ethylene glycol)

ACS Omega ◽  
2018 ◽  
Vol 3 (9) ◽  
pp. 11883-11889 ◽  
Author(s):  
Hiroto Soeta ◽  
Giada Lo Re ◽  
Akihiro Masuda ◽  
Shuji Fujisawa ◽  
Tsuguyuki Saito ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Cellulose Triacetate ◽  
Surface Grafting ◽  
Poly Ethylene Glycol ◽  
Grafting Density ◽  
Poly Ethylene

Controlling the Physical Behavior and Biological Performance of Liposome Formulations Through Use of Surface Grafted Poly(ethylene Glycol)

2002 ◽  
Vol 22 (2) ◽  
pp. 225-250 ◽  
Author(s):  
C. Allen ◽  
N. Dos Santos ◽  
R. Gallagher ◽  
G.N.C. Chiu ◽  
Y. Shu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Protein Binding ◽  
Chemical Properties ◽  
Total Serum Protein ◽  
Total Serum ◽  
Poly Ethylene Glycol ◽  
Binding Studies ◽  
Poly Ethylene

The presence of poly(ethylene glycol) (PEG) at the surface of a liposomal carrier has been clearly shown to extend the circulation lifetime of the vehicle. To this point, the extended circulation lifetime that the polymer affords has been attributed to the reduction or prevention of protein adsorption. However, there is little evidence that the presence of PEG at the surface of a vehicle actually reduces total serum protein binding. In this review we examine all aspects of PEG in order to gain a better understanding of how the polymer fulfills its biological role. The physical and chemical properties of the polymer are explored and compared to properties of other hydrophilic polymers. An evidence based assessment of several in vitro protein binding studies as well as in vivo pharmacokinetics studies involving PEG is included. The ability of PEG to prevent the self-aggregation of liposomes is considered as a possible means by which it extends circulation longevity. Also, a “dysopsonization” phenomenon where PEG actually promotes binding of certain proteins that then mask the vehicle is discussed.

scholarly journals Effect of Poly(ethylene glycol) Grafting Density on Methylcellulose Fibril Formation

2018 ◽  
Vol 51 (23) ◽  
pp. 9413-9421 ◽  
Author(s):  
Svetlana Morozova ◽  
Peter W. Schmidt ◽  
Frank S. Bates ◽  
Timothy P. Lodge
Keyword(s):  
Ethylene Glycol ◽  
Fibril Formation ◽  
Poly Ethylene Glycol ◽  
Grafting Density ◽  
Poly Ethylene

scholarly journals A non-sacrificial method for the quantification of poly(ethylene glycol) grafting density on gold nanoparticles for applications in nanomedicine

2019 ◽  
Vol 10 (7) ◽  
pp. 2067-2074 ◽  
Author(s):  
Jun Lu ◽  
Yao Xue ◽  
Rui Shi ◽  
Jing Kang ◽  
Chao-Yang Zhao ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Splitting Algorithm ◽  
H Nmr ◽  
Grafting Density ◽  
Poly Ethylene

A multi-Lorentzian-splitting algorithm is used to distinguish the 1H NMR signal of free PEG from that of grafted PEG, therefore allowing monitoring of the grafting process in situ.

scholarly journals Salt-Induced Control of the Grafting Density in Poly(ethylene glycol) Brush Layers by a Grafting-to Approach

Langmuir ◽  
2018 ◽  
Vol 34 (15) ◽  
pp. 4455-4464 ◽  
Author(s):  
Roberto Ortiz ◽  
Stefan Olsen ◽  
Esben Thormann
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Grafting Density ◽  
Poly Ethylene

Grafting Density Impacts Local Nanoscale Hydrophobicity in Poly(ethylene glycol) Brushes

2018 ◽  
Vol 7 (4) ◽  
pp. 498-503 ◽  
Author(s):  
David Faulón Marruecos ◽  
Daniel F. Kienle ◽  
Joel L. Kaar ◽  
Daniel K. Schwartz
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Grafting Density ◽  
Poly Ethylene

scholarly journals Correlation between Grafting Density and Confined Crystallization Behavior of Poly(ethylene glycol) Grafted to Silica

2019 ◽  
Vol 52 (4) ◽  
pp. 1505-1516 ◽  
Author(s):  
Xiangning Wen ◽  
Yunlan Su ◽  
Yudan Shui ◽  
Weiwei Zhao ◽  
Alejandro J. Müller ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Crystallization Behavior ◽  
Poly Ethylene Glycol ◽  
Confined Crystallization ◽  
Grafting Density ◽  
Poly Ethylene

Functionalized Poly(ethylene glycol)-Grafted Polysiloxane Monolayers for Control of Protein Binding

Langmuir ◽  
2002 ◽  
Vol 18 (8) ◽  
pp. 3255-3262 ◽  
Author(s):  
Nan Xia ◽  
Yunhua Hu ◽  
David W. Grainger ◽  
David G. Castner
Keyword(s):  
Ethylene Glycol ◽  
Protein Binding ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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