Multiple modes of chromatin remodeling by Forkhead box proteins

2012 ◽  
Vol 1819 (7) ◽  
pp. 707-715 ◽  
Author(s):  
Avin S. Lalmansingh ◽  
Sudipan Karmakar ◽  
Yetao Jin ◽  
Akhilesh K. Nagaich
Keyword(s):  
Chromatin Remodeling ◽  
Multiple Modes ◽  
Forkhead Box ◽  
Forkhead Box Proteins

Forkhead box proteins: tuning forks for transcriptional harmony

2013 ◽  
Vol 13 (7) ◽  
pp. 482-495 ◽  
Author(s):  
Eric W.-F. Lam ◽  
Jan J. Brosens ◽  
Ana R. Gomes ◽  
Chuay-Yeng Koo
Keyword(s):  
Forkhead Box ◽  
Tuning Forks ◽  
Forkhead Box Proteins

scholarly journals PPAR and Oxidative Stress: Con() Catenating NRF2 and FOXO

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Simone Polvani ◽  
Mirko Tarocchi ◽  
Andrea Galli
Keyword(s):  
Oxidative Stress ◽  
Nuclear Receptor ◽  
Energy Homeostasis ◽  
Peroxisome Proliferator ◽  
Related Factor ◽  
Central Importance ◽  
Forkhead Box ◽  
Forkhead Box Proteins ◽  
And Oxidative Stress

Peroxisome-proliferator activator receptorγ(PPARγ) is a nuclear receptor of central importance in energy homeostasis and inflammation. Recent experimental pieces of evidence demonstrate that PPARγis implicated in the oxidative stress response, an imbalance between antithetic prooxidation and antioxidation forces that may lead the cell to apoptotic or necrotic death. In this delicate and intricate game of equilibrium, PPARγstands out as a central player devoted to the quenching and containment of the damage and to foster cell survival. However, PPARγdoes not act alone: indeed the nuclear receptor is at the point of interconnection of various pathways, such as the nuclear factor erythroid 2-related factor 2 (NRF2), Wnt/β-catenin, and forkhead box proteins O (FOXO) pathways. Here we reviewed the role of PPARγin response to oxidative stress and its interaction with other signaling pathways implicated in this process, an interaction that emerged as a potential new therapeutic target for several oxidative-related diseases.

scholarly journals Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Young Suk Yu ◽  
Hijai R. Shin ◽  
Dongha Kim ◽  
Seon Ah Baek ◽  
Seon Ah Choi ◽  
...  
Keyword(s):  
Chromatin Remodeling ◽  
Arginine Methylation ◽  
Glucose Starvation ◽  
Arginine Methyltransferase ◽  
Forkhead Box ◽  
Genome Wide ◽  
Signaling Axis ◽  
Subsequent Activation ◽  
Catabolic Process

AbstractAutophagy is a catabolic process through which cytoplasmic components are degraded and recycled in response to various stresses including starvation. Recently, transcriptional and epigenetic regulations of autophagy have emerged as essential mechanisms for maintaining homeostasis. Here, we identify that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Pontin chromatin-remodeling factor under glucose starvation, and methylated Pontin binds Forkhead Box O 3a (FOXO3a). Genome-wide analyses and biochemical studies reveal that methylated Pontin functions as a platform for recruiting Tip60 histone acetyltransferase with increased H4 acetylation and subsequent activation of autophagy genes regulated by FOXO3a. Surprisingly, CARM1-Pontin-FOXO3a signaling axis can work in the distal regions and activate autophagy genes through enhancer activation. Together, our findings provide a signaling axis of CARM1-Pontin-FOXO3a and further expand the role of CARM1 in nuclear regulation of autophagy.

scholarly journals The Dominant Role of Forkhead Box Proteins in Cancer

2018 ◽  
Vol 19 (10) ◽  
pp. 3279 ◽  
Author(s):  
Duc-Hiep Bach ◽  
Nguyen Long ◽  
Thi-Thu-Trang Luu ◽  
Nguyen Anh ◽  
Sung Kwon ◽  
...  
Keyword(s):  
Cancer Research ◽  
Transcription Factors ◽  
Therapeutic Strategy ◽  
Dominant Role ◽  
Dependent Manner ◽  
Biological Processes ◽  
Forkhead Box ◽  
Forkhead Box Proteins ◽  
Multiple Levels

Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.

The role of Forkhead Box O 3a (FoxO3a) Transcription Factors in the Pathogenesis of Pulmonary Fibrosis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
HM Al-Tamari ◽  
M Eschenhagen ◽  
A Schmall ◽  
R Savai ◽  
HA Ghofrani ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Pulmonary Fibrosis ◽  
Forkhead Box
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