Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein

2006 ◽  
Vol 1759 (7) ◽  
pp. 348-358 ◽  
Author(s):  
Patrizia Berselli ◽  
Stefania Zava ◽  
Elena Sottocornola ◽  
Simona Milani ◽  
Bruno Berra ◽  
...  
Keyword(s):  
Extended Form ◽  
Gm3 Synthase ◽  
Mrna Variant

Study of the Comparative Solvation Behaviour of Na+ and Cu+ Cations in Acetonitrile + N,N-Dimethylformamide Mixtures at 298.15 K

2004 ◽  
Vol 59 (9) ◽  
pp. 615-620 ◽  
Author(s):  
Dip Singh Gill ◽  
Hardeep Anand ◽  
J. K. Puri
Keyword(s):  
Molar Conductance ◽  
Viscosity Data ◽  
Extended Form ◽  
Composition Region ◽  
Conductance Data ◽  
Reference Electrolyte ◽  
B Coefficients

Viscosity and molar conductance of Bu4NBPh4, Bu4NClO4, [Cu(CH3CN)4]ClO4, NaClO4 and NaBPh4 have been measured in the concentration ranges 0.02 - 0.5 mol dm−3 and 0.0005 - 0.0065 mol dm−3 at 298.15 K in AN + DMF mixtures containing 0, 10, 20, 40, 60, 75, 80, 90, and 100 mol % DMF. The viscosity data have been analyzed by the extended form of the Jones-Dole equation in the form: (η/η0) = 1+AC1/2+BC+DC2 to evaluate B and D parameters and the conductance data by the Shedlovsky equation to evaluate Λo and KA values of the salts. Ionic viscosity B-coefficients (B±) and ionic molar conductances (λ◦ i) have been calculated by using Bu4NBPh4 as a reference electrolyte. Solvated radii (ri) for Na+, Cu+ and ClO4 − have been estimated by using Gill’s modification of Stokes’ law. The variation of B± and ri as a function of mol % DMF shows that both Na+ and Cu+ are highly solvated in AN + DMF mixtures over the entire composition region. The solvation passes through a maximum between 40 to 80 mol % DMF. Both Na+ and Cu+ are more strongly solvated between 40 to 80 mol % DMF. Cu+ is relatively more strongly solvated than Na+ in AN + DMF mixtures. ClO4 − shows poor solvation in AN + DMF mixtures.

Net charges and valence AO's in the methylamines; the hydrogen basis set and the properties of nitrogen

1985 ◽  
Vol 63 (7) ◽  
pp. 1487-1491 ◽  
Author(s):  
Giuseppe Del Re ◽  
Sándor Fliszár ◽  
Michel Comeau ◽  
Claude Mijoule
Keyword(s):  
Basis Set ◽  
Basis Sets ◽  
Methyl Groups ◽  
Extended Form ◽  
Amine Nitrogen ◽  
Methyl Group ◽  
Net Charges ◽  
Extended Basis

Net charges and valence AO's for ammonia, methylamine, dimethylamine, and trimethylamine were calculated using extended basis sets. Superposition effects, evaluated by replacing Pople's standard 6-31G* basis by an extended form in which the basis of the ammonia H atoms and of the methyl groups of trimethylamine are retained in the treatment of each molecule, indicate that the quality of the treatment of amine nitrogen atoms is strongly dependent on the number of methyl groups. A new, augmented basis is proposed for the hydrogens, which appears to be reasonably well balanced: comparison with familiar (e.g., 6-31G*) calculations illustrates in what manner the treatment of nitrogen is worsened when even just one methyl group is replaced by hydrogen unless the impoverishment of the basis is suitably taken care of.

scholarly journals Intracrine angiotensin II functions originate from noncanonical pathways in the human heart

2016 ◽  
Vol 311 (2) ◽  
pp. H404-H414 ◽  
Author(s):  
Carlos M. Ferrario ◽  
Sarfaraz Ahmad ◽  
Jasmina Varagic ◽  
Che Ping Cheng ◽  
Leanne Groban ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Functional Significance ◽  
Vascular Remodeling ◽  
Human Heart ◽  
Renin Angiotensin System ◽  
Ang Ii ◽  
Extended Form ◽  
Angiotensin I ◽  
Angiotensin System ◽  
Ras Genes

Although it is well-known that excess renin angiotensin system (RAS) activity contributes to the pathophysiology of cardiac and vascular disease, tissue-based expression of RAS genes has given rise to the possibility that intracellularly produced angiotensin II (Ang II) may be a critical contributor to disease processes. An extended form of angiotensin I (Ang I), the dodecapeptide angiotensin-(1–12) [Ang-(1–12)], that generates Ang II directly from chymase, particularly in the human heart, reinforces the possibility that an alternative noncanonical renin independent pathway for Ang II formation may be important in explaining the mechanisms by which the hormone contributes to adverse cardiac and vascular remodeling. This review summarizes the work that has been done in evaluating the functional significance of Ang-(1–12) and how this substrate generated from angiotensinogen by a yet to be identified enzyme enhances knowledge about Ang II pathological actions.

scholarly journals II. On an extended form of the index symbol in the calculus of operations

1860 ◽  
Vol 150 ◽  
pp. 13-42
Keyword(s):  
Mathematical Journal ◽  
Extended Form ◽  
The Subject

In the following paper I propose to resume more in detail the subject of a communication made to the Cambridge and Dublin Mathematical Journal (vol. viii. p. 25). The present investigations are restricted to the case of two variables. § 1. The Theory of ∇ and ∇ 1 .

scholarly journals Curcumin Downregulates Human GM3 Synthase (hST3Gal V) Gene Expression with Autophagy Induction in Human Colon Carcinoma HCT116 Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Miri Lee ◽  
Hyunju Choi ◽  
Kyoung-Sook Kim ◽  
Dong-Hyun Kim ◽  
Cheorl-Ho Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Luciferase Reporter ◽  
Gm3 Synthase ◽  
Human Colon Carcinoma ◽  
Autophagy Induction ◽  
Promoter Deletion Analysis ◽  
V Gene ◽  
Hct116 Cells

Our recent report showed that curcumin, polyphenolic compound isolated from the herb Curcuma longa, upregulated the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis with autophagy induction in human lung adenocarcinoma A549 cells. In this study, on the contrary to this finding, we demonstrated that curcumin downregulated the gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 synthesis with autophagy induction in human colon carcinoma HCT116 cells. To clarify the mechanism leading to the downregulation of hST3Gal V gene expression in curcumin-treated HCT116 cells, we analyzed the curcumin-inducible promoter of the hST3Gal V gene by luciferase reporter assays. Promoter deletion analysis demonstrated that the -177 to -83 region, which includes putative binding sites for transcription factors NFY, CREB/ATF, SP1, EGR3, and MZF1, acts as the curcumin-responsive promoter of the hST3Gal V gene. Site-directed mutagenesis and chromatin immunoprecipitation analysis demonstrated that the CREB/ATF binding site at -143 is pivotal for curcumin-induced downregulation of hST3Gal V gene in HCT116 cells. The transcriptional activation of hST3Gal V in HCT116 cells was significantly repressed by an inhibitor of AMP-activated protein kinase (AMPK). These results suggest that AMPK signal pathway mediates hST3Gal V gene expression in HCT116 cells.

An exposure scale for marine shores in western Norway

1978 ◽  
Vol 58 (4) ◽  
pp. 975-996 ◽  
Author(s):  
D. H. Dalby ◽  
E. B. Cowell ◽  
W. J. Syratt ◽  
J. H. Crothers
Keyword(s):  
Species Abundance ◽  
Shell Shape ◽  
Rocky Shores ◽  
Shape Variation ◽  
Nucella Lapillus ◽  
Extended Form ◽  
Independent Evidence ◽  
The North ◽  
Western Norway ◽  
The North Sea

A rocky shore exposure scale, intended primarily for use in the Fensfjord area, Western Norway, has been prepared. This scale is developed from an earlier scale devised by Ballantine for Milford Haven, Wales, making use of species abundance curves along the wave exposure gradient. Independent evidence for the validity of the scale is provided by shell shape variation in Nucella lapillus and by the height of the black lichen zone in the supralittoral fringe. The successive steps in the preparation of the scale are outlined, definitions of the exposure grades are given in tabular form for the restricted set of species analysed numerically and descriptions are provided in an extended form to provide a fuller picture for users of the scale. It is believed that the scale will prove applicable to other rocky shores around the North Sea.

scholarly journals Reconciling NMR Structures of the HIV-1 Nucleocapsid Protein (NCp7) using Extensive Polarizable Force Field Free-Energy Simulations

2020 ◽  
Author(s):  
Léa El Khoury ◽  
Frédéric Célerse ◽  
Louis Lagardere ◽  
Luc-Henri Jolly ◽  
Étienne Derat ◽  
...  
Keyword(s):  
Free Energy ◽  
Nucleocapsid Protein ◽  
Extended Form ◽  
Polarizable Force Field ◽  
Relative Free Energy ◽  
Nmr Structures ◽  
Reference Protein ◽  
Energy Simulations ◽  
Hiv 1 ◽  
Most Probable Structure

Using polarizable (AMOEBA) and non-polarizable (CHARMM) force fields, we compare the relative free-energy stability of two extreme conformations of the HIV-1 NCp7 nucleocapsid that had been previously experimentally advocated to prevail in solution. Using accelerated sampling techniques, we show that they differ in stability by no more than 0.75-1.9 kcal/mol depending on the reference protein sequence. While the extended form appears to be the most probable structure, both forms should thus coexist in water explaining the differing NMR findings.<br>

On Riccati's extended form

1998 ◽  
Vol 69 (1-2) ◽  
pp. 133-147
Author(s):  
Ravi P. Agarwal ◽  
Katalin Balla
Keyword(s):  
Extended Form
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