scholarly journals TNAP stimulates vascular smooth muscle cell trans-differentiation into chondrocytes through calcium deposition and BMP-2 activation: Possible implication in atherosclerotic plaque stability

2017 ◽  
Vol 1863 (3) ◽  
pp. 643-653 ◽  
Author(s):  
Maya Fakhry ◽  
Monika Roszkowska ◽  
Anne Briolay ◽  
Carole Bougault ◽  
Alain Guignandon ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Atherosclerotic Plaque ◽  
Calcium Deposition ◽  
Plaque Stability

scholarly journals CD73 regulates vascular smooth muscle cell functions and facilitates atherosclerotic plaque formation

IUBMB Life ◽  
2015 ◽  
Vol 67 (11) ◽  
pp. 853-860 ◽  
Author(s):  
Jiayin Yang ◽  
Rongrong Jian ◽  
Jiangang Yu ◽  
Xiuling Zhi ◽  
Xiaohong Liao ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Atherosclerotic Plaque ◽  
Plaque Formation ◽  
Cell Functions ◽  
Atherosclerotic Plaque Formation

scholarly journals Attenuating Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on Vascular Smooth Muscle Cell Phenotype Changes to Osteoblastic Cells and Vascular Calcification Induced by High Fat Diet

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2777
Author(s):  
Myeongjoo Son ◽  
Seyeon Oh ◽  
Ji Tae Jang ◽  
Chul-Hyun Park ◽  
Kuk Hui Son ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Vascular Calcification ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
High Fat Diet ◽  
Calcium Deposition ◽  
High Fat

Advanced glycation end products/receptor for AGEs (AGEs/RAGEs) or Toll like receptor 4 (TLR4) induce vascular smooth muscle cell (VSMC) phenotype changes in osteoblast-like cells and vascular calcification. We analyzed the effect of Ecklonia cava extract (ECE) or pyrogallol-phloroglucinol-6,6-bieckol (PPB) on VSMC phenotype changes and vascular calcification prompted by a high-fat diet (HFD). HFD unregulated RAGE, TLR4, transforming growth factor beta (TGFβ), bone morphogenetic protein 2 (BMP2), protein kinase C (PKC), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signals in the aorta of mice. ECE and PPB restored the increase of those signal pathways. AGE- or palmitate-treated VSMC indicated similar changes with the animal. HFD increased osteoblast-like VSMC, which was evaluated by measuring core-binding factor alpha-1 (CBFα-1) and osteocalcin expression and alkaline phosphatase (ALP) activity in the aorta. ECE and PPB reduced vascular calcification, which was analyzed by the calcium deposition ratio, and Alizarin red S stain was increased by HFD. PPB and ECE reduced systolic, diastolic, and mean blood pressure, which increased by HFD. PPB and ECE reduced the phenotype changes of VSMC to osteoblast-like cells and vascular calcification and therefore lowered the blood pressure.

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