scholarly journals In utero exposure to gestational diabetes mellitus conditions TLR4 and TLR2 activated IL-1beta responses in spleen cells from rat offspring

2016 ◽  
Vol 1862 (11) ◽  
pp. 2137-2146 ◽  
Author(s):  
Qian Li ◽  
Troy J. Pereira ◽  
Brittany L. Moyce ◽  
Thomas H. Mahood ◽  
Christine A. Doucette ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
In Utero ◽  
In Utero Exposure ◽  
Spleen Cells ◽  
Rat Offspring

In utero exposure to gestational diabetes mellitus and long term endocrine morbidity of the offspring

2018 ◽  
Vol 144 ◽  
pp. 231-235 ◽  
Author(s):  
Hanaa Abokaf ◽  
Ilana Shoham-Vardi ◽  
Ruslan Sergienko ◽  
Daniella Landau ◽  
Eyal Sheiner
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
In Utero ◽  
In Utero Exposure

149-OR: In Utero Exposure to Gestational Diabetes Mellitus Is Associated with Increased Food Intake and Orbital Frontal Cortex Responses to Food Cues

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 149-OR
Author(s):  
SHAN H. LUO ◽  
BRENDAN C. ANGELO ◽  
TING CHOW ◽  
JASMIN ALVES ◽  
THOMAS A. BUCHANAN ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Food Intake ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Frontal Cortex ◽  
In Utero ◽  
In Utero Exposure ◽  
Orbital Frontal Cortex ◽  
Food Cues

scholarly journals Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA

2016 ◽  
Vol 130 (21) ◽  
pp. 1955-1967 ◽  
Author(s):  
Jeanie B. Tryggestad ◽  
Anu Vishwanath ◽  
Shaoning Jiang ◽  
Ashwini Mallappa ◽  
April M. Teague ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Endothelial Cell ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Mirna Expression ◽  
Umbilical Vein ◽  
In Utero ◽  
In Utero Exposure ◽  
Human Umbilical Vein

In utero exposure to diabetes results in changes in miRNA expression. These changes affect target proteins known to function in energy homoeostasis and may predispose the children to future metabolic disease.

Cardiovascular risk factors in offspring exposed to gestational diabetes mellitus in utero: systematic review and meta-analysis

2020 ◽  
Vol 11 (6) ◽  
pp. 599-616 ◽  
Author(s):  
Maleesa M. Pathirana ◽  
Zohra S. Lassi ◽  
Claire T. Roberts ◽  
Prabha H. Andraweera
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Systematic Review ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Meta Analysis ◽  
In Utero

AbstractGestational diabetes mellitus (GDM) is a pregnancy complication that affects one in seven pregnancies. Emerging evidence demonstrates that children born of pregnancies complicated by GDM may be at increased risk of cardiovascular disease (CVD) in adulthood. Therefore, the aim of this study was to determine cardiovascular risk factors in offspring exposed to GDM in utero. PubMed, CINAHL, SCOPUS, and EMBASE databases were searched. Information was extracted on established CVD risk factors including blood pressure, lipids, blood glucose, fasting insulin, body mass index (BMI), and endothelial/microvascular function. The review protocol is registered in PROSPERO (CRD42018094983). Prospective and retrospective studies comparing offspring exposed to GDM compared to controls (non-GDM pregnancies) were considered. We included studies that defined GDM based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) definition, or prior definitions. The PRISMA guidelines were followed in conducting this systematic review. Methodological quality was assessed using the Newcastle–Ottawa Quality Assessment Scale. Study selection, data extraction, and quality assessment were done by two independent reviewers. The data were pooled using a random-effects model. Of 59 eligible studies, 24 were included in the meta-analysis. Offspring exposed to GDM had higher systolic blood pressure (mean difference (MD): 1.75 mmHg, 95% CI 0.57–2.94; eight studies, 7264 participants), BMI z-score (MD 0.11, 95% CI 0.02–0.20; nine studies, 8759 participants), and glucose (standard MD 0.43, 95% CI 0.08–0.77; 11 studies, 6423 participants) than control participants. In conclusion, offspring exposed to GDM have elevated systolic blood pressure, BMI, and glucose. Those exposed to GDM in utero may benefit from early childhood blood pressure measurements.

Glucose Intolerance and Cardiometabolic Risk in Children Exposed to Maternal Gestational Diabetes Mellitus in Utero

PEDIATRICS ◽  
2008 ◽  
Vol 122 (6) ◽  
pp. 1229-1234 ◽  
Author(s):  
W. H. Tam ◽  
R. C. W. Ma ◽  
X. Yang ◽  
G. T. C. Ko ◽  
P. C. Y. Tong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Glucose Intolerance ◽  
Cardiometabolic Risk ◽  
In Utero
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