scholarly journals Iron sulfur clusters in complex I of Yarrowia lipolytica characterized by cw- and pulsed EPR

2012 ◽  
Vol 1817 ◽  
pp. S64
Author(s):  
Klaus Zwicker ◽  
Philipp Spindler ◽  
Volker Zickermann ◽  
Thomas Prisner ◽  
Ulrich Brandt
Keyword(s):  
Yarrowia Lipolytica ◽  
Complex I ◽  
Iron Sulfur Clusters ◽  
Pulsed Epr ◽  
Iron Sulfur

Cluster N1 of complex I from Yarrowia lipolytica studied by pulsed EPR spectroscopy

2006 ◽  
Vol 11 (3) ◽  
pp. 343-350 ◽  
Author(s):  
T. Maly ◽  
L. Grgic ◽  
K. Zwicker ◽  
V. Zickermann ◽  
U. Brandt ◽  
...  
Keyword(s):  
Yarrowia Lipolytica ◽  
Epr Spectroscopy ◽  
Complex I ◽  
Pulsed Epr

scholarly journals The multitude of iron–sulfur clusters in respiratory complex I

2016 ◽  
Vol 1857 (8) ◽  
pp. 1068-1072 ◽  
Author(s):  
Emmanuel Gnandt ◽  
Katerina Dörner ◽  
Marc F.J. Strampraad ◽  
Simon de Vries ◽  
Thorsten Friedrich
Keyword(s):  
Complex I ◽  
Iron Sulfur Clusters ◽  
Respiratory Complex ◽  
Iron Sulfur ◽  
Respiratory Complex I

scholarly journals Disproportionate Deficiency of Iron-Sulfur Clusters and Subunits of Complex I in Mitochondrial Encephalomyopathy

1989 ◽  
Vol 25 (2) ◽  
pp. 194-201 ◽  
Author(s):  
Takashi Ichiki ◽  
Masashi Tanaka ◽  
Masanori Kobayashi ◽  
Naruji Sugiyama ◽  
Hiroshi Suzuki ◽  
...  
Keyword(s):  
Complex I ◽  
Mitochondrial Encephalomyopathy ◽  
Iron Sulfur Clusters ◽  
Iron Sulfur

scholarly journals The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters

2021 ◽  
Vol 7 (8) ◽  
pp. eabf0717
Author(s):  
Florian A. Schober ◽  
David Moore ◽  
Ilian Atanassov ◽  
Marco F. Moedas ◽  
Paula Clemente ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Complex I ◽  
Cancer Metabolism ◽  
Iron Sulfur Cluster ◽  
Protein Targets ◽  
Iron Sulfur Clusters ◽  
Mitochondrial Energy Metabolism ◽  
Iron Sulfur ◽  
The One ◽  
Cluster Biosynthesis

Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to mitochondria, but it remains unclear how one-carbon availability connects to mitochondrial function. Here, we show that the one-carbon metabolite and methyl group donor S-adenosylmethionine (SAM) is pivotal for energy metabolism. A gradual decline in mitochondrial SAM (mitoSAM) causes hierarchical defects in fly and mouse, comprising loss of mitoSAM-dependent metabolites and impaired assembly of the oxidative phosphorylation system. Complex I stability and iron-sulfur cluster biosynthesis are directly controlled by mitoSAM levels, while other protein targets are predominantly methylated outside of the organelle before import. The mitoSAM pool follows its cytosolic production, establishing mitochondria as responsive receivers of one-carbon units. Thus, we demonstrate that cellular methylation potential is required for energy metabolism, with direct relevance for pathophysiology, aging, and cancer.

Functional sulfurtransferase is associated with mitochondrial complex I fromYarrowia lipolytica, but is not required for assembly of its iron-sulfur clusters

FEBS Letters ◽  
2005 ◽  
Vol 579 (30) ◽  
pp. 6781-6785 ◽  
Author(s):  
Albina Abdrakhmanova ◽  
Krzysztof Dobrynin ◽  
Klaus Zwicker ◽  
Stefan Kerscher ◽  
Ulrich Brandt
Keyword(s):  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Iron Sulfur Clusters ◽  
Iron Sulfur
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