scholarly journals Evidence for a relationship between mitochondrial Complex I activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: Effects of mitochondrial antioxidants

2012 ◽  
Vol 1817 (5) ◽  
pp. 828-837 ◽  
Author(s):  
Remedios Garcia-Bou ◽  
Milagros Rocha ◽  
Nadezda Apostolova ◽  
Raul Herance ◽  
Antonio Hernandez-Mijares ◽  
...  
Keyword(s):  
Aldehyde Dehydrogenase ◽  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Complex I Activity

CFM6 is an Essential CRM Protein Required for the Splicing of nad5 Transcript in Arabidopsis Mitochondria

2021 ◽  
Author(s):  
Wei-Chih Lin ◽  
Ya-Huei Chen ◽  
Shin-Yuan Gu ◽  
Hwei-Ling Shen ◽  
Kai-Chau Huang ◽  
...  
Keyword(s):  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
High Accumulation ◽  
Stunted Growth ◽  
Growth Defects ◽  
Group I ◽  
Or Genes ◽  
Complex I Activity ◽  
Intron 4

Abstract Plant CRM domain-containing proteins are capable of binding RNA to facilitate the splicing of group I or II introns in chloroplasts, but their functions in mitochondria are less clear. In the present study, Arabidopsis thaliana CFM6, a protein with a single CRM domain, was expressed in most plant tissues, particularly in flower tissues, and restricted to mitochondria. Mutation of CFM6 causes severe growth defects, including stunted growth, curled leaves, delayed embryogenesis, and pollen development. CFM6 functions specifically in the splicing of group II intron 4 of nad5, which encodes a subunit of mitochondrial complex I, as evidenced by the loss of nad5 intron 4 splicing and high accumulation of its pretranscripts in cfm6 mutants. The phenotypic and splicing defects of cfm6 were rescued in transgenic plants overexpressing 35S::CFM6-YFP. Splicing failure in cfm6 also led to the loss of complex I activity and to its improper assembly. Moreover, dysfunction of complex I induced the expression of proteins or genes involved in alternative respiratory pathways in cfm6. Collectively, CFM6, a previously uncharacterized CRM domain-containing protein, is specifically involved in the cis-splicing of nad5 intron 4 and plays a pivotal role in mitochondrial complex I biogenesis and normal plant growth.

Synthesis and Mitochondrial Complex I Activity of Annonaceous Trans and Cis Solamins Precursors

2004 ◽  
Vol 1 (4) ◽  
pp. 316-322 ◽  
Author(s):  
Julie Defretin ◽  
Christophe Gleye ◽  
Diego Cortes ◽  
Xavier Franck ◽  
Reynald Hocquemiller ◽  
...  
Keyword(s):  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Complex I Activity

scholarly journals METB-15. REGULATION OF BIOENERGETICS THROUGH DUAL INHIBITION OF ALDEHYDE DEHYDROGENASE AND MITOCHONDRIAL COMPLEX I SUPPRESSES GLIOBLASTOMA TUMORSPHERES

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi131-vi131 ◽  
Author(s):  
Junseong Park ◽  
Jin-Kyong Shim ◽  
Joon Hee Kang ◽  
Eui Hyun Kim ◽  
Jong Hee Chang ◽  
...  
Keyword(s):  
Aldehyde Dehydrogenase ◽  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Dual Inhibition
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