scholarly journals Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice

2011 ◽  
Vol 1807 (9) ◽  
pp. 1095-1105 ◽  
Author(s):  
Miranda Nabben ◽  
Irina G. Shabalina ◽  
Esther Moonen-Kornips ◽  
Denis van Beurden ◽  
Barbara Cannon ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Damage ◽  
Ros Production ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria

scholarly journals Olive oil-supplemented diet alleviates acute heat stress-induced mitochondrial ROS production in chicken skeletal muscle

2009 ◽  
Vol 297 (3) ◽  
pp. R690-R698 ◽  
Author(s):  
Ahmad Mujahid ◽  
Yukio Akiba ◽  
Masaaki Toyomizu
Keyword(s):  
Skeletal Muscle ◽  
Heat Stress ◽  
Membrane Potential ◽  
Oxidative Damage ◽  
Olive Oil ◽  
Ros Production ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Mitochondrial Ros ◽  
Acute Heat Stress

We have previously shown that avian uncoupling protein (avUCP) is downregulated on exposure to acute heat stress, stimulating mitochondrial reactive oxygen species (ROS) production and oxidative damage. In this study, we investigated whether upregulation of avUCP could attenuate oxidative damage caused by acute heat stress. Broiler chickens ( Gallus gallus) were fed either a control diet or an olive oil-supplemented diet (6.7%), which has been shown to increase the expression of UCP3 in mammals, for 8 days and then exposed either to heat stress (34°C, 12 h) or kept at a thermoneutral temperature (25°C). Skeletal muscle mitochondrial ROS (measured as H2O2) production, avUCP expression, oxidative damage, mitochondrial membrane potential, and oxygen consumption were studied. We confirmed that heat stress increased mitochondrial ROS production and malondialdehyde levels and decreased the amount of avUCP. As expected, feeding birds an olive oil-supplemented diet increased the expression of avUCP in skeletal muscle mitochondria and decreased ROS production and oxidative damage. Studies on mitochondrial function showed that heat stress increased membrane potential in state 4, which was reversed by feeding birds an olive oil-supplemented diet, although no differences in basal proton leak were observed between control and heat-stressed groups. These results show that under heat stress, mitochondrial ROS production and olive oil-induced reduction of ROS production may occur due to changes in respiratory chain activity as well as avUCP expression in skeletal muscle mitochondria.

scholarly journals Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria

1998 ◽  
Vol 25 (9) ◽  
pp. 1089-1097 ◽  
Author(s):  
Achim Lass ◽  
Barbara H. Sohal ◽  
Richard Weindruch ◽  
Michael J. Forster ◽  
Rajindar S. Sohal
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Damage ◽  
Caloric Restriction ◽  
Muscle Mitochondria ◽  
Mouse Skeletal Muscle ◽  
Skeletal Muscle Mitochondria

Determinants of maximal whole-body fat oxidation in elite cross-country skiers: Role of skeletal muscle mitochondria

2018 ◽  
Vol 28 (12) ◽  
pp. 2494-2504 ◽  
Author(s):  
Sune Dandanell ◽  
Anne-Kristine Meinild-Lundby ◽  
Andreas B. Andersen ◽  
Paul F. Lang ◽  
Laura Oberholzer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Fat ◽  
Fat Oxidation ◽  
Whole Body ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Cross Country
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