P5 Modulation of local field potential power of the subthalamic nucleus during incremental isometric force generation in patients with Parkinson’s disease

Basal Ganglia ◽  
2011 ◽  
Vol 1 (2) ◽  
pp. 106-107
Author(s):  
Esther Florin ◽  
Haidar Salimi Dafsari ◽  
Michael T. Barbe ◽  
Christiane Reck ◽  
K. Amande M. Pauls ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Local Field ◽  
Local Field Potential ◽  
Isometric Force ◽  
Field Potential ◽  
Force Generation

The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease

2005 ◽  
Vol 194 (1) ◽  
pp. 212-220 ◽  
Author(s):  
Andrea A. Kühn ◽  
Thomas Trottenberg ◽  
Anatol Kivi ◽  
Andreas Kupsch ◽  
Gerd-Helge Schneider ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
The Relationship

The subthalamic nucleus is involved in successful inhibition in the stop-signal task: A local field potential study in Parkinson's disease

2013 ◽  
Vol 239 ◽  
pp. 1-12 ◽  
Author(s):  
Manuel Alegre ◽  
Jon Lopez-Azcarate ◽  
Ignacio Obeso ◽  
Leonora Wilkinson ◽  
Maria C. Rodriguez-Oroz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Potential Study

scholarly journals Selection of Optimal Programming Contacts Based on Local Field Potential Recordings From Subthalamic Nucleus in Patients With Parkinson's Disease

Neurosurgery ◽  
2010 ◽  
Vol 67 (2) ◽  
pp. 390-397 ◽  
Author(s):  
Nuri Firat Ince ◽  
Akshay Gupte ◽  
Thomas Wichmann ◽  
James Ashe ◽  
Thomas Henry ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
The United States ◽  
Hand Movements ◽  
Frequency Spectra ◽  
Optimal Programming

Abstract BACKGROUND In the United States, the most commonly used surgical treatment for patients with Parkinson's disease is the implantation of deep brain stimulation (DBS) electrodes within the subthalamic nucleus. However, DBS device programming remains difficult and is a possible source of decreased efficacy. OBJECTIVE We investigated the relationship between local field potential (LFP) activities in the subthalamic nucleus and the therapeutic response to programming. METHODS We recorded LFPs with macroelectrodes placed unilaterally for DBS in 4 PD patients, 3 weeks after implantation, before the start of log-term DBS. Power-frequency spectra were calculated for each of 7 possible electrode contacts or contact pairs, over multiple 5- to 10-minute quiet waking epochs and over 30-second epochs during hand movements. Subsequently, DBS devices were programmed, with testing to determine which electrode contacts or contact pairs demonstrated optimal therapeutic efficacy. RESULTS For each patient, the contact pair found to provide optimal efficacy was associated with the highest energy in the β (13–32 Hz) and γ (48–220 Hz) bands during postoperative LFP recordings at rest and during hand movements. Activities in other frequency bands did not show significant correlations between LFP power and optimal electrode contacts. CONCLUSION Postoperative subband analysis of LFP recordings in β and γ frequency ranges may be used to select optimal electrode contacts. These results indicate that LFP recordings from implanted DBS electrodes can provide important clues to guide the optimization of DBS therapy in individual patients.

scholarly journals Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson’s disease

Brain ◽  
2020 ◽  
Vol 143 (2) ◽  
pp. 582-596 ◽  
Author(s):  
Saed Khawaldeh ◽  
Gerd Tinkhauser ◽  
Syed Ahmar Shah ◽  
Katrin Peterman ◽  
Ines Debove ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Subthalamic Nucleus ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
Beta Frequency Band ◽  
Potential Activity ◽  
Beta Frequency

Abstract Whilst exaggerated bursts of beta frequency band oscillatory synchronization in the subthalamic nucleus have been associated with motor impairment in Parkinson’s disease, a plausible mechanism linking the two phenomena has been lacking. Here we test the hypothesis that increased synchronization denoted by beta bursting might compromise information coding capacity in basal ganglia networks. To this end we recorded local field potential activity in the subthalamic nucleus of 18 patients with Parkinson’s disease as they executed cued upper and lower limb movements. We used the accuracy of local field potential-based classification of the limb to be moved on each trial as an index of the information held by the system with respect to intended action. Machine learning using the naïve Bayes conditional probability model was used for classification. Local field potential dynamics allowed accurate prediction of intended movements well ahead of their execution, with an area under the receiver operator characteristic curve of 0.80 ± 0.04 before imperative cues when the demanded action was known ahead of time. The presence of bursts of local field potential activity in the alpha, and even more so, in the beta frequency band significantly compromised the prediction of the limb to be moved. We conclude that low frequency bursts, particularly those in the beta band, restrict the capacity of the basal ganglia system to encode physiologically relevant information about intended actions. The current findings are also important as they suggest that local subthalamic activity may potentially be decoded to enable effector selection, in addition to force control in restorative brain-machine interface applications.

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