Safety and efficacy of vaccination against streptococcus pneumonia in patients with rheumatic diseases

2007 ◽  
Vol 6 (5) ◽  
pp. 312-314 ◽  
Author(s):  
Ori Elkayam ◽  
Jacob Ablin ◽  
Dan Caspi
Author(s):  
Cara D. Varley ◽  
Kevin L. Winthrop

In general, live attenuated vaccines are contraindicated in pregnancy and with immunosuppression, especially biologics. Prior to pregnancy and initiation of immunosuppressive therapy, attempts should be made to administer recommended vaccines to protect the health of both the woman and child. There is limited safety and efficacy data for many inactivated, toxoid, and subunit/conjugate vaccines in the setting of pregnancy and biologic therapy. In addition, vaccines in general may have diminished immunogenicity if administered during biologic therapy. This chapter focuses on the current recommendations, immunogenicity, and contraindications for vaccination of women of child-bearing age with rheumatic diseases who may be taking or considering initiation of disease-modifying antirheumatic drugs (DMARDs).


RMD Open ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. e001553
Author(s):  
Hendrik Schulze-Koops ◽  
Christof Specker ◽  
Alla Skapenko

Vaccination against SARS-CoV-2 has become available and will hopefully end the current pandemic. Understandably, patients with inflammatory rheumatic diseases (iRMDs) and their physicians are feverishly preoccupied with questions about vaccination and the vaccines against SARS-CoV-2. However, as it will take months before all patients with iRMDs will have access to the vaccines, measures that are taken now in order to increase potential safety and efficacy of the vaccines may impose a risk for the patients with regard to reactivation of their underlying iRMD. The ad hoc commission ‘Covid-19’ and the board of directors of the German Society for Rheumatology have addressed this topic and have developed considerations, which are intended to answer urgent questions, to take away concerns and fears and to make initial recommendations for patients with iRMDs.


2006 ◽  
Vol 13 (2-4) ◽  
pp. 349-351 ◽  
Author(s):  
Ori Elkayam

Vaccination against influenza is currently recommended for patients with rheumatoid arthritis (RA). The safety and efficacy of vaccination in patients suffering from rheumatic diseases is still a matter of debate. This review summarizes the studies performed on the safety and immunogenicity of influenza vaccination in patients with RA as well as the rheumatic complications of the vaccine in otherwise healthy persons. Several trials have shown that the vaccine induces an adequate humoral response and does not induce clinical exacerbation of RA. Rheumatic complications (mainly vasculitis) following influenza vaccination in the general population are scarce.


2005 ◽  
Vol 173 (4S) ◽  
pp. 218-218
Author(s):  
William DeFoor ◽  
Denise Ferguson ◽  
Susan Mashni ◽  
Deborah Reeves ◽  
Lisa Creelman ◽  
...  
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