Exact computation of amplification for a class of nonlinear systems arising from cellular signaling pathways

Automatica ◽  
2006 ◽  
Vol 42 (11) ◽  
pp. 1987-1992 ◽  
Author(s):  
Eduardo D. Sontag ◽  
Madalena Chaves
Keyword(s):  
Nonlinear Systems ◽  
Signaling Pathways ◽  
Cellular Signaling ◽  
Exact Computation

scholarly journals Oncogenic re-wiring of cellular signaling pathways

Oncogene ◽  
2007 ◽  
Vol 26 (9) ◽  
pp. 1268-1275 ◽  
Author(s):  
T Pawson ◽  
N Warner
Keyword(s):  
Signaling Pathways ◽  
Cellular Signaling

scholarly journals Mixed-linkage ubiquitin chains as complex regulators of cellular signaling pathways

2019 ◽  
Vol 75 (a1) ◽  
pp. a385-a385
Author(s):  
Simin Rahighi ◽  
Henry van den Bedem ◽  
Soichi Wakatsuki
Keyword(s):  
Signaling Pathways ◽  
Cellular Signaling

scholarly journals STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane

2018 ◽  
Vol 19 (7) ◽  
pp. 2108 ◽  
Author(s):  
Elisabetta Rubini ◽  
Fabio Altieri ◽  
Silvia Chichiarelli ◽  
Flavia Giamogante ◽  
Stefania Carissimi ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Cell Lines ◽  
Molecular Mechanisms ◽  
Cellular Signaling ◽  
Environmental Pollutants ◽  
Altered Expression ◽  
Exposed Population ◽  
Wide Range ◽  
Hepg2 Cell Lines

Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption. Among OCPs, particular attention was focused on the effects of β-hexaclorocyclohexane (β-HCH), a widely common pollutant. A detailed epidemiological study carried out on exposed population in the “Valle del Sacco” found correlations between the incidence of a wide range of diseases and the occurrence of β-HCH contamination. Taking into account the pleiotropic role of the protein signal transducer and activator of transcription 3 (STAT3), its function as a hub protein in cellular signaling pathways triggered by β-HCH was investigated in different cell lines corresponding to tissues that are especially vulnerable to damage by environmental pollutants. Materials and Methods: Human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cell lines were treated with 10 μM β-HCH in the presence or absence of specific inhibitors for different receptors. All samples were subjected to analysis by immunoblotting and RT-qPCR. Results and Conclusions: The preliminary results allow us to hypothesize the involvement of STAT3, through both its canonical and non-canonical pathways, in response to β-HCH. Moreover, we ascertained the role of STAT3 as a master regulator of energy metabolism via the altered expression and localization of HIF-1α and PKM2, respectively, resulting in a Warburg-like effect.

scholarly journals Pharmacological Activity of Eriodictyol: The Major Natural Polyphenolic Flavanone

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Zirong Deng ◽  
Sabba Hassan ◽  
Muhammad Rafiq ◽  
Hongshui Li ◽  
Yang He ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Signaling Pathways ◽  
Pharmacological Activity ◽  
Cellular Signaling ◽  
Hepatoprotective Activity ◽  
Signaling Cascades ◽  
Citrus Fruits ◽  
Skin Protection ◽  
Modes Of Action ◽  
Health Standards

Eriodictyol is a flavonoid that belongs to a subclass of flavanones and is widespread in citrus fruits, vegetables, and medicinally important plants. Eriodictyol has been anticipated to explain the method of its activity via multiple cellular signaling cascades. Eriodictyol is an effective natural drug source to maintain higher health standards due to its excellent therapeutic roles in neuroprotection, cardioprotective activity, hepatoprotective activity, antidiabetes and obesity, and skin protection and having highly analgesic, antioxidant, and anti-inflammatory effects, antipyretic and antinociceptive actions, antitumor activity, and much more. This review aims to highlight the modes of action of eriodictyol against various diseases via multiple cellular signaling pathways.

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