Acute Kidney Injury After Prophylactic Cefuroxime and Gentamicin in Patients Undergoing Primary Hip and Knee Arthroplasty—A Propensity Score–Matched Study

2018 ◽  
Vol 33 (9) ◽  
pp. 3009-3015 ◽  
Author(s):  
Adam Tucker ◽  
Paul Hegarty ◽  
Paul J. Magill ◽  
Janine Blaney ◽  
Lynne V. Armstrong ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Propensity Score ◽  
Knee Arthroplasty ◽  
Kidney Injury ◽  
Hip And Knee Arthroplasty ◽  
Matched Study

Vancomycin with concomitant piperacillin/tazobactam vs. cefepime or meropenem associated acute kidney injury in the critically ill: A multicenter propensity score-matched study

2022 ◽  
Vol 67 ◽  
pp. 134-140
Author(s):  
Mitchell S. Buckley ◽  
Ivan A. Komerdelj ◽  
Paul A. D'Alessio ◽  
Pooja Rangan ◽  
Sumit K. Agarwal ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Propensity Score ◽  
Critically Ill ◽  
Kidney Injury ◽  
Matched Study

scholarly journals Acute kidney injury following prophylactic flucloxacillin and gentamicin in primary hip and knee arthroplasty

2020 ◽  
Author(s):  
Judi Graham ◽  
Emma Borthwick ◽  
Christopher Hill ◽  
Janine Blaney ◽  
Nicola Gallagher ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Knee Arthroplasty ◽  
Prophylactic Antibiotic ◽  
Kidney Injury ◽  
Binary Logistic Regression ◽  
Surgical Site Infections ◽  
Ideal Body Weight ◽  
High Dose ◽  
Binary Logistic Regression Model ◽  
Hip And Knee Arthroplasty

Abstract Background Following concerns regarding the emergence of Clostridium difficile infection in 2010, we changed antibiotic prophylaxis in patients undergoing primary hip and knee arthroplasty from cefuroxime to flucloxacillin and single-dose (SD) gentamicin. A subsequent perceived increase in the incidence of post-operative acute kidney injury (AKI) led us to evaluate the AKI incidence between different prophylactic antibiotic regimes used at our centre. Methods We examined the incidence of AKI as defined by Kidney Disease: Improving Global Outcomes criteria in 1588 patients undergoing primary hip or knee arthroplasty from January 2010 to January 2015. Patients received the following prophylactic antibiotic regimes: 8 g flucloxacillin in four divided doses and SD gentamicin 1.5 mg/kg ideal body weight (IBW; maximum dose 120 mg; n = 400), 8 g flucloxacillin alone in four divided doses (n = 400), SD cefuroxime (n = 400), triple-dose (TD) cefuroxime (n = 188) and teicoplanin with SD gentamicin 1.5 mg/kg IBW (n = 200). Results The incidence of AKI was as follows: flucloxacillin and gentamicin (13%); flucloxacillin alone (8.5%); SD cefuroxime (2%); TD cefuroxime (0.5%); and teicoplanin and gentamicin (3%). Of the six patients who developed Stage 3 AKI, all were in the flucloxacillin and gentamicin group. The odds ratio for the development of AKI derived from a binary logistic regression model was highest in the flucloxacillin and gentamicin group [7.79 (95% confidence interval 3.54–17.14), P < 0.0001]. Conclusions Our findings suggest that the use of prophylactic high-dose flucloxacillin and gentamicin should be used with caution in patients undergoing primary hip or knee arthroplasty without a clear advantage in reducing surgical site infections given the association with increased rates of AKI.

Acute Kidney Injury Following Failed Total Hip and Knee Arthroplasty

2018 ◽  
Vol 33 (10) ◽  
pp. 3297-3303 ◽  
Author(s):  
Anju Yadav ◽  
Pouya Alijanipour ◽  
Colin T. Ackerman ◽  
Siddharth Karanth ◽  
William J. Hozack ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Knee Arthroplasty ◽  
Kidney Injury ◽  
Total Hip ◽  
Hip And Knee Arthroplasty

scholarly journals SO040A SIMPLE CARE BUNDLE FOR USE IN ACUTE KIDNEY INJURY - A PROPENSITY SCORE MATCHED STUDY

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i18-i18
Author(s):  
Nitin Kolhe ◽  
Timothy Reilly ◽  
Janson C. H. Leung ◽  
Kirtsy Swinscoe ◽  
Richard J. Fluck ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Propensity Score ◽  
Kidney Injury ◽  
Care Bundle ◽  
Matched Study

scholarly journals Efficacy and safety of intrawound vancomycin in primary hip and knee arthroplasty

2020 ◽  
Vol 9 (11) ◽  
pp. 778-788
Author(s):  
Hong Xu ◽  
Jingli Yang ◽  
Jinwei Xie ◽  
Zeyu Huang ◽  
Qiang Huang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Knee Arthroplasty ◽  
Assessment Tool ◽  
Joint Infection ◽  
Kidney Injury ◽  
Cochrane Library ◽  
Wound Complications ◽  
Efficacy And Safety ◽  
Superficial Infection ◽  
Hip And Knee Arthroplasty

Aims The efficacy and safety of intrawound vancomycin for preventing surgical site infection in primary hip and knee arthroplasty is uncertain. Methods A systematic review of the literature was conducted, indexed from inception to March 2020 in PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar databases. All studies evaluating the efficacy and/or safety of intrawound vancomycin in patients who underwent primary hip and knee arthroplasty were included. Incidence of periprosthetic joint infection (PJI), superficial infection, aseptic wound complications, acute kidney injury, anaphylactic reaction, and ototoxicity were meta-analyzed. Results were reported as odds ratios (ORs) and 95% confidence intervals (CIs). The quality of included studies was assessed using the risk of bias in non-randomized studies of interventions (ROBINS-I) assessment tool. Results Nine studies involving 4,607 patients were included. Intrawound vancomycin was associated with lower incidence of PJI (30 patients (1.20%) vs 58 control patients (2.75%); OR 0.44, 95% CI 0.28 to 0.69) and simultaneous acute kidney injury (four patients (0.28%) vs four control patients (0.35%), OR 0.71, 95% CI 0.19 to 2.55). However, it did not reduce risk of superficial infection (four patients (0.67%) vs six control patients (1.60%), OR 0.60, 95% CI 0.17 to 2.12) and was associated with higher incidence of aseptic wound complications (23 patients (2.15%) vs eight in control patients (0.96%), OR 2.39, 95% CI 1.09 to 5.23). Four studies reported no anaphylactic reactions and three studies reported no ototoxicity in any patient group. Conclusion The current literature suggests that intrawound vancomycin used in primary hip and knee arthroplasty may reduce incidence of PJI, but it may also increase risk of aseptic wound complications. Cite this article: Bone Joint Res 2020;9(11):778–788.

scholarly journals Risk Factors and Effect of Acute Kidney Injury on Outcomes Following Total Hip and Knee Arthroplasty

2021 ◽  
Vol 36 (1) ◽  
pp. 331-338
Author(s):  
Michael Yayac ◽  
Zachary S. Aman ◽  
Alexander J. Rondon ◽  
Timothy L. Tan ◽  
P. Maxwell Courtney ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Knee Arthroplasty ◽  
Kidney Injury ◽  
Total Hip ◽  
Hip And Knee Arthroplasty
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