Non-invasive brain stimulation of the aging brain: State of the art and future perspectives

2016 ◽  
Vol 29 ◽  
pp. 66-89 ◽  
Author(s):  
Elisa Tatti ◽  
Simone Rossi ◽  
Iglis Innocenti ◽  
Alessandro Rossi ◽  
Emiliano Santarnecchi
2019 ◽  
Vol 49 (2) ◽  
pp. 66-71
Author(s):  
Ondřej Klempíř ◽  
Radim Krupička

Deep brain stimulation of the globus pallidus internus is an efective symptomatic treatment for pharmacoresistant dystonic syndromes, where pathophysiological mechanisms of action are not yet fully understood. The aim of this review article is to provide an overview of the state-of-the-art approaches for processing of microelectrode recordings in dystonia; in order to define biomarkers to identify patients who will benefit from the clinical deep brain stimulation. For this purpose, the essential elements of microelectrode processing are examined. Next, we investigate a real example of spike sorting processing in this field. Herein, we describe baseline elements of microrecordings processing including data collection, preprocessing phase, features computation, spike detection and sorting and finally, advanced spike train data analysis. This study will help readers acquire the necessary information about these elements and their associated techniques. Thus, this study is supposed to assist during identification and proposal of interesting clinical hypotheses in the field of single unit neuronal recordings in dystonia.


Author(s):  
Elena G. Sergeeva ◽  
Petra Henrich-Noack ◽  
MichaÅ‚ Bola ◽  
Bernhard A. Sabel

Author(s):  
Tegan Penton ◽  
Caroline Catmur ◽  
Michael J Banissy ◽  
Geoffrey Bird ◽  
Vincent Walsh

Abstract Use of non-invasive brain stimulation methods (NIBS) has become a common approach to study social processing in addition to behavioural, imaging and lesion studies. However, research using NIBS to investigate social processing faces challenges. Overcoming these is important to allow valid and reliable interpretation of findings in neurotypical cohorts, but also to allow us to tailor NIBS protocols to atypical groups with social difficulties. In this review, we consider the utility of brain stimulation as a technique to study and modulate social processing. We also discuss challenges that face researchers using NIBS to study social processing in neurotypical adults with a view to highlighting potential solutions. Finally, we discuss additional challenges that face researchers using NIBS to study and modulate social processing in atypical groups. These are important to consider given that NIBS protocols are rarely tailored to atypical groups before use. Instead, many rely on protocols designed for neurotypical adults despite differences in brain function that are likely to impact response to NIBS.


2019 ◽  
Vol 43 (3) ◽  
pp. 539-551 ◽  
Author(s):  
Leo Massari ◽  
Franco Benazzo ◽  
Francesco Falez ◽  
Dario Perugia ◽  
Luca Pietrogrande ◽  
...  

2019 ◽  
Vol 17 (1) ◽  
pp. 116-126 ◽  
Author(s):  
Noah S. Philip ◽  
David O. Sorensen ◽  
Daniel M. McCalley ◽  
Colleen A. Hanlon

2019 ◽  
Vol 98 (4) ◽  
pp. 279-289
Author(s):  
Paulo J. C. Suen ◽  
Andre R. Brunoni

Noninvasive brain stimulation therapies are a promising field for the development of new protocols for the treatment of neuropsychiatric disorders. They are based on the stimulation of neural networks with the intent of modeling their synaptic activity to adequate levels. For this, it is necessary to precisely determine which networks are related to which brain functions, and the normal activation level of each of these networks, so that it is possible to direct the stimulation to the affected networks in order to induce the desired effects. These relationships are under intense investigation by the scientific community, and will contribute to the advancement of treatments by neurostimulation, with the emergence of increasingly accurate and effective protocols for different disorders. Currently, the most used techniques are Transcranial Direct Current Stimulation and Transcranial Magnetic Stimulation, with the most common applications being for treating Major Depressive Disorder. The advancement of research in this field may determine new target networks for stimulation in the treatment of other disorders, extending the application of these techniques and also our knowledge about brain functioning.


Author(s):  
Joyce Gomes-Osman ◽  
Aprinda Indahlastari ◽  
Peter J. Fried ◽  
Danylo L. F. Cabral ◽  
Jordyn Rice ◽  
...  

2021 ◽  
Author(s):  
Mario Manto ◽  
Georgios P. D. Argyropoulos ◽  
Tommaso Bocci ◽  
Pablo A. Celnik ◽  
Louise A. Corben ◽  
...  

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