CKIP-1: A scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions

2013 ◽  
Vol 12 (1) ◽  
pp. 276-281 ◽  
Author(s):  
Jing Nie ◽  
Lin Liu ◽  
Fuchu He ◽  
Xiaobing Fu ◽  
Weidong Han ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Therapeutic Target ◽  
Scaffold Protein ◽  
Potential Therapeutic Target ◽  
Physiological Functions ◽  
Multiple Signaling

scholarly journals Molecular Mechanisms of Glial Cells Related Signaling Pathways Involved in the Neuroinflammatory Response of Depression

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Junhui Wang ◽  
Jie Qin ◽  
Peng Wang ◽  
Yu Sun ◽  
Qi Zhang
Keyword(s):  
Psychiatric Disorders ◽  
Signaling Pathways ◽  
Glial Cells ◽  
Therapeutic Target ◽  
Molecular Mechanisms ◽  
Pathological Change ◽  
Basic Knowledge ◽  
Pathological Features ◽  
Potential Therapeutic Target ◽  
Neuroinflammatory Response

Dysfunction of the glial cells, such as astrocytes and microglia, is one of the pathological features in many psychiatric disorders, including depression, which emphasizes that glial cells driving neuroinflammation is not only an important pathological change in depression but also a potential therapeutic target. In this review, we summarized a recent update about several signaling pathways in which glial cells may play their roles in depression through neuroinflammatory reactions. We focused on the basic knowledge of these signaling pathways by elaborating each of them. This review may provide an updated image about the recent advances on these signaling pathways that are essential parts of neuroinflammation involved in depression.

scholarly journals A Novel Potential Therapeutic Target as Adjuvant Treatment for Cancer: The Pharmacological Interference on the Ca2+/Camp Cellular Signaling Pathways

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Bueno Bergantin Leandro ◽  
Ruggero Errante Paolo ◽  
Andrade Leite Alberto ◽  
Menezes-Rodrigues Francisco Sandro ◽  
Caricati-Neto Afonso
Keyword(s):  
Signaling Pathways ◽  
Adjuvant Treatment ◽  
Therapeutic Target ◽  
Cellular Signaling ◽  
Potential Therapeutic Target

scholarly journals FBXW7 circular RNA regulates proliferation, migration and invasion of colorectal carcinoma through NEK2, mTOR, and PTEN signaling pathways in vitro and in vivo

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Haoran Lu ◽  
Baofu Yao ◽  
Xinyuan Wen ◽  
Baoqing Jia
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cell Migration ◽  
Signaling Pathways ◽  
Cell Lines ◽  
Therapeutic Target ◽  
Circular Rna ◽  
Migration And Invasion ◽  
Potential Therapeutic Target

Abstract Backgrounds A number of circular RNAs (circRNAs) have been identified in various cancer including F-box and WD repeat domain containing 7 (FBXW7) circular RNA (circ-FBXW7), which can suppress glioma cell growth. However, the role of circ-FBXW7 in colorectal cancer (CRC) remains unclear. We aimed to investigate the effect and mechanisms of circ-FBXW7 on CRC progression. Methods The expression of circ-FBXW7 in CRC patients was detected by PCR. Stably knockdown of circ-FBXW7 (si circ-FBXW7) cell lines and overexpression of circ-FBXW7 (oe circ-FBXW7) cell lines were constructed by small interfering RNA method and plasmids transfection in CRC SW480 and SW620 cells. The functional experiments including cell proliferation, migration and invasion were carried out by cell counting kit-8 (CCK-8) assay, wound healing assay and trans well assay. The xenograft animal models were established to evaluate the effect and the underlying molecular mechanisms of circ-FBXW7 on CRC progression. Results CRC samples had a significantly lower level of circ-FBXW7 compared to normal tissue. si circ-FBXW7 notably promoted the proliferation, colony formation, cell migration and invasion of CRC cell in vitro. On contrast, circ-FBXW7 overexpressed significantly suppressed CRC cell proliferation, migration and invasion. Similarly, si circ-FBXW7 stimulated the tumor growth and circ-FBXW7 overexpression repressed the tumor progression in SW480 and SW620 tumor models, which suggested that circ-FBXW7 could serve as a target biomarker of CRC. Further study found that si circ-FBXW7 up-regulated the mRNA and protein expressions of NEK2 and mTOR, and diminished the PTEN expression. Whereas, overexpressed circ-FBXW7 induced the tumor suppression via reversing the expressions of NEK2, mTOR, and PTEN. Conclusion circ-FBXW7 plays a major role in controlling the progression of CRC through NEK2, mTOR, and PTEN signaling pathways and may be a potential therapeutic target for CRC treatment. Graphical abstract Circ-FBXW7 controls the progression of CRC through NEK2, mTOR, and PTEN signaling pathways and its overexpression inhibits colorectal cancer cell migration and invasion, suggesting the potential therapeutic target for CRC treatment.

scholarly journals Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target

Surgery ◽  
2016 ◽  
Vol 159 (1) ◽  
pp. 163-171 ◽  
Author(s):  
Lawrence A. Shirley ◽  
Samantha McCarty ◽  
Ming-Chen Yang ◽  
Motoyasu Saji ◽  
Xiaoli Zhang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Integrin Linked Kinase ◽  
And Migration ◽  
Thyroid Cancer Cells

scholarly journals The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis?

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 111 ◽  
Author(s):  
Esra’a Keewan ◽  
Saleh A. Naser
Keyword(s):  
Rheumatoid Arthritis ◽  
Notch Signaling ◽  
Signaling Pathways ◽  
Therapeutic Target ◽  
Limited Data ◽  
Potential Therapeutic Target ◽  
Cellular Processes ◽  
Pathological Conditions ◽  
Infection And Inflammation

Notch signaling coordinates numerous cellular processes and has been implicated in many pathological conditions, including rheumatoid arthritis (RA). Although the role of Notch signaling in development, maturation, differentiation, and activation of lymphocytes has been comprehensively reported, less is known about its role in myeloid cells. Certainly, limited data are available about the role of Notch signaling in macrophages during inflammation and infection. In this review, we discuss the recent advances pertaining to the role of Notch signaling in differentiation, activation, and metabolism of macrophages during inflammation and infection. We also highlight the reciprocal interplay between Notch signaling and other signaling pathways in macrophages under different inflammatory and infectious conditions including pathogenesis of RA. Finally, we discuss approaches that could consider Notch signaling as a potential therapeutic target against infection- and inflammation-driven diseases.

scholarly journals Toll-like Receptors Signaling Pathways as a Potential Therapeutic Target in Cardiovascular Disease

2018 ◽  
Vol 24 (17) ◽  
pp. 1887-1898 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Maryam Ghandehari ◽  
Motahareh Heydari-majd ◽  
Sima Seifi ◽  
Ramin Mardani ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Immune System ◽  
Signaling Pathways ◽  
Cardiac Remodeling ◽  
Therapeutic Target ◽  
Good Evidence ◽  
Toll Like Receptors ◽  
Potential Therapeutic Target

Cardiovascular Disease (CVD) is one of the most important causes of morbidity and mortality, and associated with an important economic burden globally. Over the last decade, the prevalence of CVD has been rising globally, and is now associated with millions of death annually in both developed and developing countries. There is good evidence that the immune system is involved in the pathophysiology of CVD. Toll-like receptors (TLRs) and their down-stream signaling pathways play an important role in the immune system. Recent studies have suggested that the TLRs are involved in atherogenesis, including stroke, myocardial infarction, ischemiareperfusion injury, cardiac remodeling and development of Heart Failure (HF). In this review we have summarized the recent studies investigating the role of TLRs in CVD and the potential for using TLRs signaling pathways as a therapeutic target in CVD.

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