The Macroeconomics of Dementia—Will the World Economy Get Alzheimer's Disease?

2012 ◽  
Vol 43 (8) ◽  
pp. 705-709 ◽  
Author(s):  
Sube Banerjee
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
World Economy ◽  
The World

scholarly journals Ethnographic reflections on selfhood, embodiment and Alzheimer's disease

2004 ◽  
Vol 24 (6) ◽  
pp. 829-849 ◽  
Author(s):  
PIA C. KONTOS
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Care Facility ◽  
Ethnographic Study ◽  
The Body ◽  
Philosophical Tradition ◽  
Cultural Significance ◽  
Term Care ◽  
Long Term Care Facility ◽  
The World

Explicit in the current construction of Alzheimer's disease is the assumption that memory impairment caused by cognitive deficiencies leads to a steady loss of selfhood. The insistence that selfhood is the exclusive privilege of the sphere of cognition has its origins in the modern western philosophical tradition that separates mind from body, and positions the former as superior to the latter. This dichotomy suggests a fundamental passivity of the body, since it is primarily cognition that is held to be essential to selfhood. In contrast to the assumed erasure of selfhood in Alzheimer's disease, and challenging the philosophical underpinnings of this assumption, this paper presents the findings of an ethnographic study of selfhood in Alzheimer's disease in a Canadian long-term care facility. It argues and demonstrates that selfhood persists even with severe dementia, because it is an embodied dimension of human existence. Using a framework of embodiment that integrates the perspectives of Merleau-Ponty and Bourdieu, it is argued that selfhood is characterised by an observable coherence and capacity for improvisation, and sustained at a pre-reflective level by the primordial and socio-cultural significance of the body. The participants in this study interacted meaningfully with the world through their embodied way of ‘being-in-the-world’.

Report of an International Psychogeriatric Association Special Meeting Work Group; Under the Cosponsorship of Alzheimer's Disease International, the European Federation of Neurological Societies, the World Health Organization, and the World Psychiatric Association

1997 ◽  
Vol 9 (S1) ◽  
pp. 11-38 ◽  
Author(s):  
Barry Reisberg ◽  
Alistair Burns ◽  
Henry Brodaty ◽  
Robin Eastwood ◽  
Martin Rossor ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Current Knowledge ◽  
Work Group ◽  
Treatment Strategies ◽  
Diagnostic Procedures ◽  
World Health ◽  
Diagnostic Process ◽  
European Federation ◽  
The World

Current knowledge with respect to the diagnosis of Alzheimer's disease (AD) is reviewed. There is agreement that AD is a characteristic clinicopathologic entity that is amenable to diagnosis. The diagnosis of AD should no longer be considered one of exclusion. Rather, the diagnostic process is one of recognition of the characteristic features of AD and of conditions that can have an impact on presentation or mimic aspects of the clinicopathologic picture. The present availability of improved prognosis, management, and treatment strategies makes the proper, and state-of-the-art, diagnosis of AD a clinical imperative in all medical settings. Concurrently, information regarding the relevance and applicability of current diagnostic procedures in diverse cultural settings must continue to accrue.

scholarly journals A Systematic Review of Clinical Decision Support Systems in Alzheimer’s Disease Domain

2021 ◽  
Vol 17 (08) ◽  
pp. 74
Author(s):  
Sherimon P.C. ◽  
Vinu Sherimon ◽  
Preethii S.P. ◽  
Rahul Nair ◽  
Renchi Mathew
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Decision Support ◽  
Decision Support System ◽  
Clinical Decision Support ◽  
Support System ◽  
Clinical Decision Support System ◽  
Memory Loss ◽  
Clinical Decision ◽  
The World

Dementia is one of the major public health issues faced by the world. Alzheimer’s disease (AD) is the most common form of dementia targeting old age groups around the world. It is a neurodegenerative condition with memory loss as its early symptom. Unfortunately, there is no cure for this disease currently. So various research in the medical and technical fields are being conducted to help people with Alzheimer’s. Many studies focus on early diagnosis of Alzheimer’s disease using clinical decision support system (CDSS) so that the progression of the disease can be slowed down to a great extent. In this context, we have undertaken a research to design and implement an ontology based Clinical decision support system for Alzheimer’s disease in Sultanate of Oman. A semantic knowledgebase (ontology) will be the core component of our Clinical decision support system. The objective of this research paper is two-fold (a) review the medical aspects of Alzheimer’s disease, and (b) review the available clinical decision support system based on ontology, robotics, and mobile applications in Alzheimer domain. Research articles published during 2011- 2020 in PubMed, Google scholar, Elsevier, SpringerLink and IEEE journals were reviewed. We found that there is various clinical decision support system which can aid physicians in suggesting diagnosis, and treatment of Alzheimer’s disease.

scholarly journals Regulation of Caenorhabditis Elegans model in Alzheimer’s Disease

2020 ◽  
Vol 185 ◽  
pp. 03043
Author(s):  
Yuxuan Jing
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Caenorhabditis Elegans ◽  
Amyloid Beta ◽  
Significant Role ◽  
Tau Protein ◽  
Specific Gene ◽  
Protein Modelling ◽  
Gene Expressions ◽  
The World

Alzheimer’s disease (AD) is affecting numerous families and individuals around the world nowadays, as the exact reason is still undetermined. At this stage, developmental treatment displays a particularly significant role in relieving symptoms for the patients. Currently, the two most well-known factors that have impacts on the diagnosis of AD are the plaques and tangles formed from amyloid-beta and tau protein. Modelling for Alzheimer’s disease is essential in understanding targeted aspects of the disease, while Caenorhabditis elegans (C.elegans) was chosen as a pivotal model. C.elegans presents dramatic priorities using orthologs for the study of AD, especially in examining the formation of the deposits and the regulations of specific gene expressions that result in this abnormality. This review discusses the properties, which C.elegans shows on the study of AD, and the achievements that have been approached using this model, as well as what other models are being tested by scientists. Properties of other models, which can overwhelm C.elegans, as well as the expectations for future modelling systems on AD are examined as well.

scholarly journals Role of the oral microbiota in the development of Alzheimer’s disease

2020 ◽  
Vol 15 (4) ◽  
pp. 231-238
Author(s):  
Natalia Gavrilova ◽  
◽  
Nikita Gladyshev ◽  
Anna Kotrova ◽  
Anastasiia Morozova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Oral Microbiota ◽  
Practical Application ◽  
Pathophysiological Role ◽  
The World ◽  
Important Practical Application

Dementia and, in particular, Alzheimer’s disease (AD), affects millions of people around the world and its prevalence is steadily rising annually. Some risk factors for AD, such as age, cannot be modified, while others could possibly be corrected. In recent years, many studies are tackling the problem of the oral and gut microbiota as a provoking factor for AD and other neurodegenerative diseases, but their relationship and specific pathophysiological mechanisms remain understudied. The microbiota of the oral cavity can be of particular importance due to the specificity of microorganisms and their localization, as well as the possibility of provoking neuroinflammation, which requires further study. This review covers the specific features of the oral microbiota, current views on the pathophysiological role of the oral microbiota in the development of AD, as well as the beneficial role of probiotics. The study of this issue can have an important practical application both for the early diagnosis of AD, and for its further treatment.

The mysteries of the human genome uncovered--medicine is changed forever

2001 ◽  
Vol 10 (2) ◽  
pp. 125-132 ◽  
Author(s):  
LG Futterman ◽  
L Lemberg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Genome ◽  
Human Health ◽  
Human Body ◽  
Molecular Basis ◽  
Human Organism ◽  
The World ◽  
Challenging Research ◽  
Health And Disease

It is impossible to overemphasize the significance of the recent announcement that 85% of the DNA of the human genome has been decoded. Physicians can now begin teasing out the secrets of human health and disease. Within the next 10 years, it may be possible to determine who may be vulnerable to illnesses like Alzheimer's disease, cancer, and diabetes. The world of medicine will be utterly transformed in a few decades. Even before decoding of the human genome is completed, scientists have begun a new and more challenging research in explaining the molecular basis of life. "Proteonomics," the cataloging and analysis of every protein in the human body looms as the next major scientific medical effort. Proteins are more varied and complex than DNA. Fifty years from now, our understanding of the human organism and its various ills will be transformed beyond recognition through genomics and proteonomics. Stay tuned!

The oldest-old and dementia at the end of life

2020 ◽  
pp. 171-180
Author(s):  
María M Corrada ◽  
Claudia H Kawas
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
End Of Life ◽  
Hippocampal Sclerosis ◽  
Oldest Old ◽  
Vascular Lesions ◽  
Age Group ◽  
Elderly Individuals ◽  
The World

The oldest-old and dementia at the end of life describes what is known about the prevalence, incidence, and risk factors for dementia in people aged 90 and older, the fastest growing segment of the population in much of the world. It reviews the main neuropathological abnormalities found during autopsy, including Alzheimer’s disease (AD), vascular lesions, and hippocampal sclerosis and discusses how these abnormalities are related to dementia in very elderly individuals. The chapter highlights differences in risk and protective factors, and underlying neuropathologies associated with dementia compared to younger elderly. Taking into consideration the rapid increase in the number of oldest-old by the middle of the century, it reviews the potential impact of interventions to reduce Alzheimer’s disease pathology on the prevalence of dementia in this age group. Finally, it presents methodological challenges in studying this age group and offers potential strategies to address some of these challenges.

TIME TO THROW IN THE TOWEL?

PEDIATRICS ◽  
1994 ◽  
Vol 93 (6) ◽  
pp. 917-917
Author(s):  
J. F. L.
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medical Association ◽  
Brain Damage ◽  
Early Onset ◽  
Neuropsychological Tests ◽  
Middle Age ◽  
Computerised Tomography ◽  
The World ◽  
Independent Inquiry

England must take the credit—or blame—for the reinvention of boxing. The sport was a popular part of the Roman games but had vanished by the 5th century. It returned some 1200 years later, when bare-fist prizefights began to be held in and around London. With help from the Marquess of Queensberry, boxing spread around the world, making money for a considerable number of boxing promoters and a smaller number of boxers. It is appropriate, then, that the British Medical Association should be actively involved in examining the sport. In its latest report, The Boxing Debate, which was issued last week, it repeats its call for a ban on boxing and asks for an independent inquiry into its safety. The briefest reading of the report should persuade even boxing's proponents of the need for an inquiry. In its appendix the report prints abstracts of recent research on what happens to boxers after they have been battered in the ring. For professional boxers, several studies make unpleasant reading. One using computerised tomography found 87 per cent of boxers, in a sample of 18, showed evidence of brain damage. Another records that 15 out of 19 young boxers register as impaired on a battery of neuropsychological tests. Particularly disturbing are three studies which show that changes found in the brains of ex-boxers are immunochemically similar to those seen in Alzheimer's disease. That raises the possibility that even boxers who retire from the ring healthy may pay the price in middle age with early onset of Alzheimer's disease.

Gender’s Effects to the Early Symptoms of Alzheimer’s Disease in 5 Asian Countries

2017 ◽  
Vol 32 (4) ◽  
pp. 194-199 ◽  
Author(s):  
Yuan-Han Yang ◽  
Kenichi Meguro ◽  
Jacqueline Dominguez ◽  
Christopher Li-Hsian Chen ◽  
Huali Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Presentation ◽  
Clinical Symptoms ◽  
Early Recognition ◽  
Dementia Care ◽  
Asian Countries ◽  
Clinical Dementia Rating ◽  
The World ◽  
Male Patients

Background: Asia has the greatest population and more patients with dementia in the world. Early recognition of clinical symptoms of Alzheimer’s disease (AD) is crucial for dementia care. In order to foster collaboration in AD care, a uniformed manner to report the early clinical symptoms of AD is necessary. Methods: We have recruited clinically diagnosed patients with AD at their very mild stage with Clinical Dementia Rating (CDR) 0.5 in Taiwan, Japan, China, Philippines, and Singapore. Demographic characteristics and psychometrics including Ascertain of Dementia-8 (AD8) questionnaire were administrated to collect and report the clinical presentation in these countries. Results: In total, 713 clinically diagnosed patients with AD at very mild stage, CDR 0.5, have been recruited from these 5 countries. “Repeats questions, stories, or statements” were consistently the frequently reported symptom across these countries. Taiwan, China, and Singapore have the higher AD8 total score compared to that in Japan and Philippines. Japan and Philippines have the gender-related differences in clinical presentation of early AD. Conclusion: Difficulties in using small trouble appliance and in handling complicated financial affairs were frequently reported in Japan female, compared to male, patients with AD. Identifying the clinical symptom of AD and the gender-related issues would be crucial in the dementia care in Asia.

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