Cardiac Troponin T (cTnT) in Hemodialysis Patients with Asymptomatic and Symptomatic Atherosclerosis

2005 ◽  
Vol 36 (4) ◽  
pp. 367-371 ◽  
Author(s):  
Radovan Hojs ◽  
Robert Ekart ◽  
Tanja Hojs Fabjan ◽  
Breda Pečovnik Balon ◽  
Maksimiljan Gorenjak
Keyword(s):  
Cardiac Troponin ◽  
Troponin T ◽  
Hemodialysis Patients ◽  
Cardiac Troponin T

Effect of Dilazep Dihydrochloride on Serum Cardiac Troponin T Levels in Hemodialysis Patients

2002 ◽  
Vol 25 (1) ◽  
pp. 50-54 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Chifuyu Ushiyama ◽  
Shiwori Osada ◽  
Kazuya Ugai ◽  
Yutaka Takahashi ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Troponin T ◽  
Hemodialysis Patients ◽  
Cardiac Troponin T ◽  
Serum Cardiac Troponin

Frequency and Cause of Cardiac Troponin T Elevation in Chronic Hemodialysis Patients from Study of Cardiovascular Magnetic Resonance

2007 ◽  
Vol 100 (5) ◽  
pp. 885-889 ◽  
Author(s):  
Christopher R. deFilippi ◽  
Eric M. Thorn ◽  
Monica Aggarwal ◽  
Abel Joy ◽  
Robert H. Christenson ◽  
...  
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Cardiac Troponin T

scholarly journals Clinical significance of cardiac troponin T in hemodialysis patients

2003 ◽  
Vol 36 (4) ◽  
pp. 259-265
Author(s):  
Yukiyasu Watanabe ◽  
Shintaro Yano ◽  
Yukihiro Shimizu ◽  
Kumeo Ono
Keyword(s):  
Clinical Significance ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Hemodialysis Patients ◽  
Cardiac Troponin T

scholarly journals High-Sensitive Cardiac Troponin T for Prediction of Cardiovascular Outcomes in Stable Maintenance Hemodialysis Patients: A 3-Year Prospective Study

2021 ◽  
pp. 1-11
Author(s):  
Linlin Sun ◽  
Yonglan Wang ◽  
Nan Zhang ◽  
Xinmiao Xie ◽  
Miao Ding ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Prognostic Value ◽  
Troponin T ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Cardiac Troponin T ◽  
All Cause Mortality ◽  
Echocardiographic Parameters ◽  
Stable Maintenance

<b><i>Background:</i></b> Hemodialysis patients, who are often excluded from cardiovascular (CV) clinical trials, are associated with higher CV morbidity and mortality. The risk stratification scheme for these patients is lacking. Therefore, this investigation examined the independent CV prognostic value of high-sensitive cardiac troponin T (hs-cTnT) and added prognostic value over echocardiographic parameters and other clinical risk predictors in asymptomatic stable maintenance hemodialysis (MHD) patients. <b><i>Methods:</i></b> 181 patients with end-stage renal disease undergoing MHD were eligible from the dialysis center of Tongren Hospital, Shanghai Jiao Tong University School of Medicine between October 2017 and September 2018. These patients were followed until September 2020 or until death. The median follow-up was 31 (IQR: 21–33) months. Outcome measures were all-cause mortality, first fatal or nonfatal CV events (CVEs), and 4-point composite major adverse CVEs (MACE). We performed multivariable Cox regression analysis using demographic, clinical, laboratory, and echocardiographic data to identify predictors of CV outcomes. We also evaluated the increased discriminative value associated with the addition of echocardiographic parameters and hs-cTnT using net reclassification improvement (NRI) and integrated discrimination improvement (IDI). <b><i>Results:</i></b> During follow-up, 37 patients died, 84 patients suffered one or more CVEs, and 78 patients developed 4-point MACE. In univariable analyses, age, dialysis vintage, diastolic blood pressure, parathyroid hormone concentrations, hs-cTnT, B-type natriuretic peptide, left ventricular mass index (LVMI), and <i>E</i>/<i>E</i>′ predicted all end points. hs-cTnT remained a strong predictor for each end point in multivariate analysis, whereas LVMI and <i>E</i>/<i>E</i>′ did not. The addition of hs-cTnT on top of clinical and echocardiographic variables was associated with improvements in reclassification for CVEs (NRI = 44.6% [15.9–74.3%], IDI = 15.9% [5.7–31.0%], all <i>p</i> &#x3c; 0.001), all-cause mortality (NRI = 35.5% [10.1–50.2%], <i>p</i> &#x3c; 0.001, IDI = 4.4% [1.3–8.5%], <i>p</i> = 0.005), and 4-point MACE (NRI = 47.2% [16.1–64.9%], <i>p</i> &#x3c; 0.001, IDI = 16.9% [5.5–37.3%], <i>p</i> = 0.005). Adding echocardiographic variables on top of clinical variables and hs-cTnT was not associated with significant improvements in NRI and IDI (all <i>p</i> &#x3e; 0.05). <b><i>Conclusions:</i></b> Our data suggest that hs-cTnT is a powerful independent predictor of CV outcome and all-cause mortality in stable MHD patients. The additional use of echocardiography for improvement of risk stratification is not supported by our results.

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