Magnetic 99m Tc- core-shell of polyethylene glycol/polyhydroxyethyl methacrylate based on Fe 3 O 4 nanoparticles: Radiation synthesis, characterization and biodistribution study in tumor bearing mice

2017 ◽  
Vol 28 (8) ◽  
pp. 1898-1910 ◽  
Author(s):  
Ahmed M. Elbarbary ◽  
I.A. Ibrahim ◽  
H.M. Shafik ◽  
Sameh H. Othman
Keyword(s):  
Polyethylene Glycol ◽  
Biodistribution Study ◽  
Core Shell ◽  
Radiation Synthesis ◽  
Tumor Bearing ◽  
Polyhydroxyethyl Methacrylate

The Effects of oil-in-Water Nanoemulsion Polyethylene Glycol Surface Density on Intracellular Stability, Pharmacokinetics, and Biodistribution in Tumor Bearing Mice

2014 ◽  
Vol 32 (4) ◽  
pp. 1475-1485 ◽  
Author(s):  
Sjoerd Hak ◽  
Zuzana Garaiova ◽  
Linda Therese Olsen ◽  
Asbjørn Magne Nilsen ◽  
Catharina de Lange Davies
Keyword(s):  
Polyethylene Glycol ◽  
Surface Density ◽  
Tumor Bearing ◽  
Oil In Water

Acylated chitosan anchored paclitaxel loaded liposomes: Pharmacokinetic and biodistribution study in Ehrlich ascites tumor bearing mice

2019 ◽  
Vol 122 ◽  
pp. 367-379 ◽  
Author(s):  
Biswarup Nanda ◽  
A.S. Manjappa ◽  
Krishna Chuttani ◽  
N.H. Balasinor ◽  
Anil K. Mishra ◽  
...  
Keyword(s):  
Ehrlich Ascites Tumor ◽  
Biodistribution Study ◽  
Ascites Tumor ◽  
Tumor Bearing ◽  
Ehrlich Ascites

scholarly journals Biodistribution Study of Niosomes in Tumor-Implanted BALB/C Mice Using Scintigraphic Imaging

2022 ◽  
Vol 12 ◽  
Author(s):  
Leanne De Silva ◽  
Ju-Yen Fu ◽  
Thet Thet Htar ◽  
Wan Hamirul Bahrin Wan Kamal ◽  
Azahari Kasbollah ◽  
...  
Keyword(s):  
Intravenous Injection ◽  
Gamma Scintigraphy ◽  
Biodistribution Study ◽  
Scintigraphic Imaging ◽  
Tumor Bearing ◽  
Tumor Accumulation ◽  
Tumor Area

The purpose of this work was to study the biodistribution of niosomes in tumor-implanted BALB/c mice using gamma scintigraphy. Niosomes were first formulated and characterized, then radiolabeled with Technetium-99 m (99mTc). The biodistribution of 99mTc-labeled niosomes was evaluated in tumor-bearing mice through intravenous injection and imaged with gamma scintigraphy. The labeled complexes possessed high radiolabeling efficiency (98.08%) and were stable in vitro (>80% after 8 h). Scintigraphic imaging showed negligible accumulation in the stomach and thyroid, indicating minimal leaching of the radiolabel in vivo. Radioactivity was found mainly in the liver, spleen and kidneys. Tumor-to-muscle ratio indicated a higher specificity of the formulation for the tumor area. Overall, the formulated niosomes are stable both in vitro and in vivo, and show preferential tumor accumulation.

Self-Assemble Behavior of Amphiphilic Diblock Copolymer of Methoxy Poly (Ethylene Glycol)/Polyester

2011 ◽  
Vol 295-297 ◽  
pp. 11-15
Author(s):  
Hao Zhou ◽  
Qing Hong Liang ◽  
Xiang Ke Shi ◽  
Li Hua Lu ◽  
Li Qun Zhang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Light Scattering ◽  
Diblock Copolymer ◽  
Diblock Copolymers ◽  
Average Diameter ◽  
Core Shell ◽  
Amphiphilic Diblock Copolymer ◽  
Amphiphilic Diblock Copolymers ◽  
Methoxy Polyethylene Glycol ◽  
Solution Polycondensation

Amphiphilic diblock copolymers based on methoxy polyethylene glycol (MePEG), 1, 6-hexanediol and maleic anhydride with different molar composition were synthesized by solution polycondensation. Self-assemble behavior of amphiphilic diblock copolymer in different solvents by dialyzing technique was discussed. The micelle morphologhy was observed by TEM. It was found that well core-shell MePEG1900/Polyester 2162 copolymer nanoparticles can be formed by self-assemble in acetone solution. In addition, the size of nanospheres measured using dynamic light scattering exhibited a narrow monodisphere size distribution and an average diameter in the ranger of less than 200nm.

scholarly journals Synthesis and Comparative Biological Properties of Ag-PEG Nanoparticles with Tunable Morphologies from Janus to Multi-Core Shell Structure

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 1787 ◽  
Author(s):  
Mengda Xu ◽  
Jie Liu ◽  
Xiankui Xu ◽  
Shanhu Liu ◽  
František Peterka ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Silver Nitrate ◽  
Shell Structure ◽  
Irradiation Time ◽  
Antibacterial Activities ◽  
Biological Properties ◽  
Hybrid Nanoparticles ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Structure

Silver nanoparticles synthesized with polymers as coating agents is an effective method to overcome their poor stability and aggregation in solution. Silver-polyethylene glycol (Ag-PEG) nanoparticles were synthesized with the thiol-functionalized polyethylene glycol (SH-PEA) as the coating, reducing and stabilizing agent. The UV irradiation time, polymer and silver nitrate concentration for the synthesis were investigated. The concentration of silver nitrate had significant effect on the morphology of Ag-PEG nanoparticles. When increasing the concentration of silver nitrate, SEM and TEM images showed that Ag-PEG nanoparticles changed from Janus to multi-core shell structure. Meanwhile, pure silver particles in the two hybrid nanoparticles presented spherical shape and had the similar size of 15 nm. The antibacterial activities and cytotoxicity of the two structural Ag-PEG nanoparticles were investigated to understand colloid morphology effect on the properties of AgNPs. The results of antibacterial activities showed that the two structural Ag-PEG nanoparticles exhibited strong antibacterial activities against Staphylococcus aureus, Escherichia coli and Bacillus subtilis. The Janus nanoparticles had larger minimal inhibitory concentration (MIC) and minimum bacterial concentration (MBC) values than the multi-core shell counterparts. The results of cytotoxicity showed the Janus Ag-PEG nanoparticles had lower toxicity than the multi-core shell nanoparticles.

Novel Polyethylene Glycol Derivatives of Melatonin and Serotonin. Ligands for Conjugation to Fluorescent Cadmium Selenide/Zinc Sulfide core shell Nanocrystals

2002 ◽  
Vol 2002 (5) ◽  
pp. 203-204 ◽  
Author(s):  
Ian D. Tomlinson ◽  
Tadd Kippeny ◽  
Laura Swafford ◽  
Nasir H. Siddiqui ◽  
Sandra J. Rosenthal
Keyword(s):  
Polyethylene Glycol ◽  
Cadmium Selenide ◽  
Fluorescence Imaging ◽  
Zinc Sulfide ◽  
Core Shell ◽  
Biological Assays ◽  
Serotonin Ligands ◽  
Derivatives Of

This paper describes the synthesis and characterisation of derivatives of melatonin and serotonin that may be attached to highly fluorescent cadmium selenide/zinc sulfide core shells nanocrystals for use in biological assays and fluorescence imaging applications.

Fabrication of Tunable Core−Shell Structured TiO2Mesoporous Microspheres Using Linear Polymer Polyethylene Glycol as Templates

2010 ◽  
Vol 114 (6) ◽  
pp. 2434-2439 ◽  
Author(s):  
Yuming Cui ◽  
Lei Liu ◽  
Bo Li ◽  
Xingfu Zhou ◽  
Nanping Xu
Keyword(s):  
Polyethylene Glycol ◽  
Linear Polymer ◽  
Core Shell
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