scholarly journals Preparation and controlled drug delivery applications of mesoporous silica polymer nanocomposites through the visible light induced surface-initiated ATRP

2017 ◽  
Vol 412 ◽  
pp. 571-577 ◽  
Author(s):  
Long Huang ◽  
Meiying Liu ◽  
Liucheng Mao ◽  
Dazhuang Xu ◽  
Qing Wan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Visible Light ◽  
Polymer Nanocomposites ◽  
Controlled Drug Delivery ◽  
Drug Delivery Applications

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

Cisplatin and doxorubicin dual-loaded mesoporous silica nanoparticles for controlled drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (96) ◽  
pp. 94160-94169 ◽  
Author(s):  
Hanwen Li ◽  
Huijuan Yu ◽  
Caiying Zhu ◽  
Jianhua Hu ◽  
Ming Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Synergistic Effect ◽  
Silica Nanoparticles ◽  
Therapeutic Efficacy ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery

Multicomponent therapeutic platforms have been proposed to minimize dosage of each drug and reduce toxicity, leading to achieving a synergistic effect and maximizing therapeutic efficacy.

Biodegradation-tunable mesoporous silica nanorods for controlled drug delivery

2015 ◽  
Vol 50 ◽  
pp. 64-73 ◽  
Author(s):  
Sung Bum Park ◽  
Young-Ho Joo ◽  
Hyunryung Kim ◽  
WonHyoung Ryu ◽  
Yong-il Park
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Controlled Drug Delivery ◽  
Silica Nanorods

An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites

Nano Research ◽  
2015 ◽  
Vol 8 (6) ◽  
pp. 1893-1905 ◽  
Author(s):  
Guofeng Luo ◽  
Weihai Chen ◽  
Huizhen Jia ◽  
Yunxia Sun ◽  
Han Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Delivery ◽  
Controlled Drug Delivery System ◽  
Gold Nanocomposites

scholarly journals Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 977 ◽  
Author(s):  
Yiluo Hu ◽  
Daham Jeong ◽  
Yohan Kim ◽  
Seonmok Kim ◽  
Seunho Jung
Keyword(s):  
Drug Delivery ◽  
Visible Light ◽  
Sinorhizobium Meliloti ◽  
Environmental Changes ◽  
Controlled Drug Delivery ◽  
Attenuated Total Reflection ◽  
Extracellular Polysaccharides ◽  
Rheological Analysis ◽  
Wide Range ◽  
Potential Applications

Hydrogel materials with a gel-sol conversion due to external environmental changes have potential applications in a wide range of fields, including controlled drug delivery. Succinoglycans are anionic extracellular polysaccharides produced by various bacteria, including Sinorhizobium species, which have diverse applications. In this study, the rheological analysis confirmed that succinoglycan produced by Sinorhizobium meliloti Rm 1021 binds weakly to various metal ions, including Fe2+ cations, to maintain a sol form, and binds strongly to Fe3+ cations to maintain a gel form. The Fe3+-coordinated succinoglycan (Fe3+-SG) hydrogel was analyzed by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, circular dichroism (CD), and field-emission scanning electron microscopy (FE-SEM). Our results revealed that the Fe3+ cations that coordinated with succinoglycan were converted to Fe2+ by a reducing agent and visible light, promoting a gel-sol conversion. The Fe3+-SG hydrogel was then successfully used for controlled drug delivery based on gel-sol conversion in the presence of reducing agents and visible light. As succinoglycan is nontoxic, it is a potential material for controlled drug delivery.

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