Layer-by-layer engineering fluorescent polyelectrolyte coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release

2015 ◽  
Vol 345 ◽  
pp. 90-98 ◽  
Author(s):  
Pengcheng Du ◽  
Xubo Zhao ◽  
Jin Zeng ◽  
Jinshan Guo ◽  
Peng Liu
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive ◽  
Layer By Layer

P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release

2015 ◽  
Vol 26 (10) ◽  
pp. 1203-1208 ◽  
Author(s):  
Yu-Jie Chang ◽  
Xi-Zhen Liu ◽  
Qing Zhao ◽  
Xiao-Hai Yang ◽  
Ke-Min Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

pH sensitive chitosan-mesoporous silica nanoparticles for targeted delivery of a ruthenium complex with enhanced anticancer effects

2016 ◽  
Vol 45 (45) ◽  
pp. 18147-18155 ◽  
Author(s):  
Gaochao Lv ◽  
Ling Qiu ◽  
Guiqing Liu ◽  
Wei Wang ◽  
Ke Li ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Ruthenium Complex ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive ◽  
Anticancer Effects

A pH sensitive mesoporous silica nanocarrier, RuNHC@MSNs-CTS-Biotin (CTS = chitosan), is developed for the targeted delivery and controlled release of a ruthenium(ii) N-heterocyclic carbene (RuNHC) complex.

Synthesis of pH-sensitive poly(β-amino ester)-coated mesoporous silica nanoparticles for the controlled release of drugs

2018 ◽  
Vol 8 (4) ◽  
pp. 853-866 ◽  
Author(s):  
William A. Talavera-Pech ◽  
Adriana Esparza-Ruiz ◽  
Patricia Quintana-Owen ◽  
Alfredo R. Vilchis-Nestor ◽  
Jesus A. Barrón-Zambrano ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive ◽  
Amino Ester

scholarly journals Cylindrical Microparticles Composed of Mesoporous Silica Nanoparticles for the Targeted Delivery of a Small Molecule and a Macromolecular Drug to the Lungs: Exemplified with Curcumin and siRNA

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 844
Author(s):  
Thorben Fischer ◽  
Inga Winter ◽  
Robert Drumm ◽  
Marc Schneider
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Alveolar Epithelial Cells ◽  
In Vitro Toxicity ◽  
Layer By Layer ◽  
Necrosis Factor Alpha ◽  
Aerodynamic Properties ◽  
Tnf Α

The transport of macromolecular drugs such as oligonucleotides into the lungs has become increasingly relevant in recent years due to their high potency. However, the chemical structure of this group of drugs poses a hurdle to their delivery, caused by the negative charge, membrane impermeability and instability. For example, siRNA to reduce tumour necrosis factor alpha (TNF-α) secretion to reduce inflammatory signals has been successfully delivered by inhalation. In order to increase the effect of the treatment, a co-transport of another anti-inflammatory ingredient was applied. Combining curcumin-loaded mesoporous silica nanoparticles in nanostructured cylindrical microparticles stabilized by the layer-by-layer technique using polyanionic siRNA against TNF-α was used for demonstration. This system showed aerodynamic properties suited for lung deposition (mass median aerodynamic diameter of 2.85 ± 0.44 µm). Furthermore, these inhalable carriers showed no acute in vitro toxicity tested in both alveolar epithelial cells and macrophages up to 48 h incubation. Ultimately, TNF-α release was significantly reduced by the particles, showing an improved activity co-delivering both drugs using such a drug-delivery system for specific inhibition of TNF-α in the lungs.

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