Improving the controlled release of water-insoluble emodin from amino-functionalized mesoporous silica

2012 ◽  
Vol 258 (17) ◽  
pp. 6366-6372 ◽  
Author(s):  
Yunqiang Xu ◽  
Chunfeng Wang ◽  
Guowei Zhou ◽  
Yue Wu ◽  
Jing Chen
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Functionalized Mesoporous Silica

scholarly journals Enhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled release

RSC Advances ◽  
2019 ◽  
Vol 9 (62) ◽  
pp. 36005-36010
Author(s):  
Bilge G. Tuna ◽  
Pinar B. Atalay ◽  
Gamze Kuku ◽  
E. Esma Acar ◽  
H. Kubra Kara ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Controlled Release ◽  
Antitumor Activity ◽  
Mesoporous Silica ◽  
Cell Surface ◽  
Hela Cell ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Cervical Cancer Cells

Carbendazim doped and aptamer-gate functionalized mesoporous silica nanoparticles targeted nucleolin on HeLa cell surface for specific delivery. This delivery system improved antitumor activity of carbendazim by about 3 folds increase of EC50 values.

scholarly journals Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marieh Pishnamazi ◽  
Hamid Hafizi ◽  
Mahboubeh Pishnamazi ◽  
Azam Marjani ◽  
Saeed Shirazian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Microcrystalline Cellulose ◽  
Release Rate ◽  
Drug Carriers ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
Remarkable Effect ◽  
Functionalized Mesoporous Silica

AbstractIn the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.

ATP-Responsive Controlled Release System Using Aptamer-Functionalized Mesoporous Silica Nanoparticles

Langmuir ◽  
2012 ◽  
Vol 28 (35) ◽  
pp. 12909-12915 ◽  
Author(s):  
Xiaoxiao He ◽  
Yingxiang Zhao ◽  
Dinggeng He ◽  
Kemin Wang ◽  
Fengzhou Xu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release System ◽  
Functionalized Mesoporous Silica ◽  
Controlled Release System

Highly efficient remote controlled release system based on light-driven DNA nanomachine functionalized mesoporous silica

Nanoscale ◽  
2012 ◽  
Vol 4 (15) ◽  
pp. 4473 ◽  
Author(s):  
Yongqiang Wen ◽  
Liping Xu ◽  
Wenqian Wang ◽  
Danyang Wang ◽  
Hongwu Du ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Release System ◽  
Highly Efficient ◽  
Functionalized Mesoporous Silica ◽  
Controlled Release System ◽  
Dna Nanomachine

Modelling the adsorption and controlled release of drugs from the pure and amino surface-functionalized mesoporous silica hosts

2018 ◽  
Vol 262 ◽  
pp. 23-34 ◽  
Author(s):  
A. Martín ◽  
V. Morales ◽  
J. Ortiz-Bustos ◽  
M. Pérez-Garnes ◽  
L.F. Bautista ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Functionalized Mesoporous Silica
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