Matrix assisted pulsed laser evaporation processing of triacetate-pullulan polysaccharide thin films for drug delivery systems

2006 ◽  
Vol 252 (13) ◽  
pp. 4647-4651 ◽  
Author(s):  
R. Cristescu ◽  
G. Dorcioman ◽  
C. Ristoscu ◽  
E. Axente ◽  
S. Grigorescu ◽  
...  
Keyword(s):  
Thin Films ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Pulsed Laser ◽  
Delivery Systems ◽  
Laser Evaporation

Coating Powders for Drug Delivery Systems Using Pulsed Laser Deposition

2006 ◽  
pp. 215-237 ◽  
Author(s):  
James D. Talton ◽  
Barbel Eppler ◽  
Margaret I. Davis ◽  
Andrew L. Mercado ◽  
James M. Fitz-Gerald
Keyword(s):  
Drug Delivery ◽  
Pulsed Laser Deposition ◽  
Drug Delivery Systems ◽  
Pulsed Laser ◽  
Delivery Systems ◽  
Laser Deposition

Thin films of polymer blends for controlled drug delivery deposited by matrix-assisted pulsed laser evaporation

2010 ◽  
Vol 96 (24) ◽  
pp. 243702 ◽  
Author(s):  
Irina Alexandra Paun ◽  
Valentin Ion ◽  
Antoniu Moldovan ◽  
Maria Dinescu
Keyword(s):  
Thin Films ◽  
Drug Delivery ◽  
Polymer Blends ◽  
Pulsed Laser ◽  
Controlled Drug Delivery ◽  
Laser Evaporation

Novel Vapor Phase biodegradable coatings for controlled drug delivery systems

2007 ◽  
Vol 1008 ◽  
Author(s):  
Arul Chakkaravarthi Arjunan ◽  
Sushant Gupta ◽  
Rajiv K Singh ◽  
Deepika Singh ◽  
Jeff Opalko
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Pulsed Laser ◽  
Morphological Characteristics ◽  
Delivery Systems ◽  
The Body ◽  
Poly Lactic Acid ◽  
Laser Method ◽  
Biodegradable Coatings

AbstractThe synthesis of nano-functionalized drug particles or drug particles with nanoscale biodegradable polymeric coatings has wider ranging applications in sustained release drug delivery systems. An important area of application includes delivery of drugs, such as proteins, peptides, and glucocorticoids via the inhalation process. The advantages of this method include, rapid absorption by the body and lack of metabolic degradation effects which is typically by some drugs during oral delivery. Here we discuss the novel pulsed laser and pulsed electron method to synthesize nanoscale biodegradable coatings of poly lactic acid (PLA) onto antiasthmatic drugs. In pulsed laser method a pulsed excimer laser ablates a thin layer of polymer which is deposited onto 1 -5 micron drug particles which are fluidized in the gas chamber. The control of the thickness, conformation and the chemistry of the nanoscale coating process will be discussed in detail. Applications of this methodology to delivery of anti asthamtic drugs and insulin will be discussed. The effect of polymer coating chemistry, molecular weight, hydrophobicity, and thickness on the sustained release characteristics will be discussed. A unique method for depositing the PLA films, pulsed electron beam deposition (PED) was used to deposit the films. This technique was tried done to overcome the difficulties like low absorption co-efficient of UV-laser. Method proved to be promising for producing smooth films and offers a better thickness control of the deposition. The RMS roughness and other morphological characteristics of PED deposited films were superior over the conventional laser ablated films.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Sign in / Sign up

Export Citation Format

Share Document