scholarly journals Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents

2020 ◽  
Vol 10 (2) ◽  
pp. 327-343 ◽  
Author(s):  
Senling Feng ◽  
Huifang Zhou ◽  
Deyan Wu ◽  
Dechong Zheng ◽  
Biao Qu ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Total Synthesis ◽  
Reversal Agents ◽  
Mdr Reversal

Design and Syntheses of Permethyl Ningalin B Analogues: Potent Multidrug Resistance (MDR) Reversal Agents of Cancer Cells

2010 ◽  
Vol 53 (14) ◽  
pp. 5108-5120 ◽  
Author(s):  
Pu Yong Zhang ◽  
Iris L. K. Wong ◽  
Clare S. W. Yan ◽  
Xiao Yu Zhang ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Reversal Agents ◽  
Mdr Reversal

ChemInform Abstract: Total Synthesis of 5-N-Acetylardeemin and Amauromine: Practical Routes to Potential MDR Reversal Agents.

ChemInform ◽  
2010 ◽  
Vol 31 (13) ◽  
pp. no-no
Author(s):  
Kristopher M. Depew ◽  
Stephen P. Marsden ◽  
Danuta Zatorska ◽  
Andrzej Zatorski ◽  
William G. Bornmann ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Reversal Agents ◽  
Mdr Reversal

scholarly journals The Effects of Synthetically Modified Natural Compounds on ABC Transporters

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 127 ◽  
Author(s):  
Daniel Dantzic ◽  
Pawan Noel ◽  
Fabrice Merien ◽  
Dong-Xu Liu ◽  
Jun Lu ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Survival Rate ◽  
Abc Transporter ◽  
Abc Transporters ◽  
Drug Absorption ◽  
Natural Compounds ◽  
Cellular Tissue ◽  
Reversal Agents ◽  
Atp Binding Cassette Transporters ◽  
Mdr Reversal

Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumulation and thus increase MDR across a variety of cancers. Overcoming MDR is one desired approach to improving the survival rate of patients. To date, a number of modulators have been identified which block the function and/or decrease the expression of ABC transporters, thereby restoring the efficacy of a range of anticancer drugs. However, clinical MDR reversal agents have thus far proven ineffective and/or toxic. The need for new, effective, well-tolerated and nontoxic compounds has led to the development of natural compounds and their derivatives to ameliorate MDR. This review evaluates whether synthetically modifying natural compounds is a viable strategy to generate potent, nontoxic, ABC transporter inhibitors which may potentially reverse MDR.

Ingol diterpenoids as P-glycoprotein-dependent multidrug resistance (MDR) reversal agents from Euphorbia marginata

2020 ◽  
Vol 95 ◽  
pp. 103546 ◽  
Author(s):  
Yao Zhang ◽  
Run-Zhu Fan ◽  
Jun Sang ◽  
Yi-Jing Tian ◽  
Jia-Qi Chen ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Mdr Reversal

ChemInform Abstract: Discovery of Highly Potent Multidrug Resistance (MDR) Reversal Agents: Aminosulfonylaryl Isoxazole Derivatives.

ChemInform ◽  
2009 ◽  
Vol 40 (36) ◽  
Author(s):  
Young Taek Han ◽  
Eun Kyung Kim ◽  
Eun Ae Kim ◽  
Eun Seon Kim ◽  
Dae Kyong Kim ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Reversal Agents ◽  
Isoxazole Derivatives ◽  
Mdr Reversal

Total Synthesis of 5-N-Acetylardeemin and Amauromine:  Practical Routes to Potential MDR Reversal Agents

1999 ◽  
Vol 121 (51) ◽  
pp. 11953-11963 ◽  
Author(s):  
Kristopher M. Depew ◽  
Stephen P. Marsden ◽  
Danuta Zatorska ◽  
Andrzej Zatorski ◽  
William G. Bornmann ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Reversal Agents ◽  
Mdr Reversal
Sign in / Sign up

Export Citation Format

Share Document