scholarly journals Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect

2019 ◽  
Vol 9 (4) ◽  
pp. 858-870 ◽  
Author(s):  
Hangyi Wu ◽  
Miaorong Yu ◽  
Yunqiu Miao ◽  
Shufang He ◽  
Zhuo Dai ◽  
...  
Keyword(s):  
Liposomal Membrane ◽  
Tumor Penetration ◽  
Membrane Rigidity

Trypsin entrapped within liposomes. Partition of a low-molecular-mass substrate as the main factor in kinetic control of hydrolysis

1991 ◽  
Vol 56 (3) ◽  
pp. 712-717 ◽  
Author(s):  
Jana Formelová ◽  
Albert Breier ◽  
Peter Gemeiner ◽  
Lubica Kurillová
Keyword(s):  
Molecular Mass ◽  
Egg Yolk ◽  
Kinetic Control ◽  
Hydrolysis Kinetics ◽  
Liposomal Membrane ◽  
Kinetics Of ◽  
Main Factor

Trypsin has been entrapped within liposomes prepared from egg yolk phospholipides by the method of controlled dialysis, and the hydrolysis kinetics of Nα-benzoyl-DL-arginine p-nitroaniline catalyzed by the liposome-entrapped trypsin has been studied by monitoring the flux of substrate and product across the liposomal membrane. The partitioning of the substrate and product between liposomal and extraliposomal environment has been found to represent the main factor in the kinetic control of the hydrolysis.

Biomimetic Liposome with Surface‐Bound Elastase for Enhanced Tumor Penetration and Chemo‐Immumotherapy

2021 ◽  
pp. 2100794
Author(s):  
Yong‐Jiang Li ◽  
Jun‐Yong Wu ◽  
Xiong‐Bin Hu ◽  
Tianjinhao Ding ◽  
Tiantian Tang ◽  
...  
Keyword(s):  
Tumor Penetration

In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianqin Yan ◽  
Zhuangzhuang Zhang ◽  
xiaohui Zhan ◽  
Keqi Chen ◽  
Yuji Pu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Deep Penetration ◽  
Tumor Penetration ◽  
Dna Nanostructure ◽  
Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

scholarly journals Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

2020 ◽  
pp. 2002589
Author(s):  
Zimu Li ◽  
Xiaoting Shan ◽  
Zhidong Chen ◽  
Nansha Gao ◽  
Wenfeng Zeng ◽  
...  
Keyword(s):  
Surface Modification ◽  
Tumor Penetration

scholarly journals ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

2019 ◽  
Vol 5 (9) ◽  
pp. eaax2770 ◽  
Author(s):  
Praneeth R. Kuninty ◽  
Ruchi Bansal ◽  
Susanna W. L. De Geus ◽  
Deby F. Mardhian ◽  
Jonas Schnittert ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Tumor Stroma ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma ◽  
Tumor Penetration ◽  
Desmoplastic Stroma ◽  
Integrin Α5

Abundant desmoplastic stroma is the hallmark for pancreatic ductal adenocarcinoma (PDAC), which not only aggravates the tumor growth but also prevents tumor penetration of chemotherapy, leading to treatment failure. There is an unmet clinical need to develop therapeutic solutions to the tumor penetration problem. In this study, we investigated the therapeutic potential of integrin α5 (ITGA5) receptor in the PDAC stroma. ITGA5 was overexpressed in the tumor stroma from PDAC patient samples, and overexpression was inversely correlated with overall survival. In vitro, knockdown of ITGA5 inhibited differentiation of human pancreatic stellate cells (hPSCs) and reduced desmoplasia in vivo. Our novel peptidomimetic AV3 against ITGA5 inhibited hPSC activation and enhanced the antitumor effect of gemcitabine in a 3D heterospheroid model. In vivo, AV3 showed a strong reduction of desmoplasia, leading to decompression of blood vasculature, enhanced tumor perfusion, and thereby the efficacy of gemcitabine in co-injection and patient-derived xenograft tumor models.

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