scholarly journals Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

2016 ◽  
Vol 6 (5) ◽  
pp. 453-459 ◽  
Author(s):  
Lai Peng ◽  
Stephanie Piekos ◽  
Grace L. Guo ◽  
Xiao-bo Zhong
Keyword(s):  
Phase I ◽  
Mouse Liver ◽  
Farnesoid X Receptor ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

scholarly journals Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver Development

2016 ◽  
Vol 39 (12) ◽  
pp. 2015-2021 ◽  
Author(s):  
Wataru Ochiai ◽  
Akiyo Hirose ◽  
Taisuke Kawamura ◽  
Kyoko Komachi ◽  
Yuka Yamamoto ◽  
...  
Keyword(s):  
Mouse Liver ◽  
Liver Development ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

scholarly journals The role of FXR in the regulation of phase‐I drug metabolizing gene expression during mouse liver maturation (1141.1)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Lai Peng ◽  
Julia Cui ◽  
Byunggil Yoo ◽  
Yun‐chen Tien ◽  
Hong Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Phase I ◽  
Mouse Liver

scholarly journals The role of nitric oxide on decreasing the hepatic drug metabolizing enzyme activity by bacterial endotoxin in rats

1999 ◽  
Vol 79 ◽  
pp. 125
Author(s):  
Kiyoyuki Kitaichi ◽  
Li Wang ◽  
Haruna Kidokoro ◽  
Mitsunori Iwase ◽  
Kenji Takagi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Enzyme Activity ◽  
Bacterial Endotoxin ◽  
Hepatic Drug ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

scholarly journals The role of cytochrome P-450 in cholesterol biogenesis and catabolism

1972 ◽  
Vol 128 (2) ◽  
pp. 237-242 ◽  
Author(s):  
Sandra D. Atkin ◽  
Eileen D. Palmer ◽  
P. D. English ◽  
B. Morgan ◽  
M. A. Cawthorne ◽  
...  
Keyword(s):  
Cholesterol Metabolism ◽  
Carbon Disulphide ◽  
Normal Serum ◽  
Liver Cholesterol ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme ◽  
Cytochrome P 450

1. Adjuvant-induced arthritis in rats is accompanied by a loss of activity of the drug-metabolizing enzyme system and a decrease in hepatic cytochrome P-450. 2. Arthritic rats have normal serum and liver cholesterol concentrations. 3. The rate of biogenesis of cholesterol in vivo and in vitro from either [14C]acetate or [14C]mevalonate in arthritic rats was the same as or greater than that found in control rats. 4. Treatment of rats with carbon disulphide (1ml/kg) resulted in a loss of drug-metabolizing-enzyme activity and increased cholesterol biogenesis. 5. The activity of cholesterol 7α-hydroxylase in adjuvant-induced arthritic rats did not differ significantly from that in control rats. 6. Rats fed with cholestyramine had an elevated hepatic cholesterol 7α-hydroxylase activity, but neither the concentration of cytochrome P-450 nor the activity of the drug-hydroxylating enzyme, aminopyrine demethylase, was affected. 7. The relationships between drug hydroxylation and cholesterol metabolism are discussed.

scholarly journals Evolution of a Major Drug Metabolizing Enzyme Defect in the Domestic Cat and Other Felidae: Phylogenetic Timing and the Role of Hypercarnivory

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18046 ◽  
Author(s):  
Binu Shrestha ◽  
J. Michael Reed ◽  
Philip T. Starks ◽  
Gretchen E. Kaufman ◽  
Jared V. Goldstone ◽  
...  
Keyword(s):  
Domestic Cat ◽  
Enzyme Defect ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme ◽  
Major Drug

scholarly journals Control of δ-aminolaevulinate synthase and haem oxygenase in chroniciron-overloaded rats

1981 ◽  
Vol 200 (1) ◽  
pp. 35-42 ◽  
Author(s):  
N G Ibrahim ◽  
J C Nelson ◽  
R D Levere
Keyword(s):  
Iron Overload ◽  
Inborn Errors ◽  
Cellular Iron ◽  
Drug Metabolizing Enzyme ◽  
Oxygenase Activity ◽  
Exogenous Agents ◽  
Haem Oxygenase ◽  
Metabolizing Enzyme ◽  
Cytochrome P 450

The hepatic porphyrias are inborn errors of porphyrin and haem biosynthesis characterized biochemically by excessive excretion of delta-aminolaevulinate (ALA), porphobilinogen and other intermediates in haem synthesis. Clinical evidence has implicated iron in the pathogenesis of several types of genetically transmitted diseases. We investigated the role of iron in haem metabolism as well as its relationship to drug-mediated induction of ALA synthase and haem oxygenase in acute and chronic iron overload. Acute iron overload in rats resulted in a marked increase in hepatic haem oxygenase that was associated with a decrease in cytochrome P-450 and an increase in ALA synthase activity. Aminopyrine N-demethylase and aniline hydroxylase activities, which are dependent on the concentration of cytochrome P-450, were also decreased. In contrast, in chronic-iron-overloaded rats, there was an adaptive increase in haem oxygenase activity and an increase in ALA synthase that was associated with normal concentrations of microsomal haem and cytochrome P-450. The induction of ALA synthase in chronic iron overload was enhanced by phenobarbital and allylisopropylacetamide, in spite of the fact that these agents did not increase haem oxygenase activity. Small doses of Co2+ were potent inducers of the haem oxygenase in chronic-iron-overloaded, but not in control, animals. We conclude that increased hepatic cellular iron may predispose certain enzymes of haem synthesis to induction by exogenous agents and thereby affect drug-metabolizing enzyme activities.

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