scholarly journals An update on the role of intestinal cytochrome P450 enzymes in drug disposition

2016 ◽  
Vol 6 (5) ◽  
pp. 374-383 ◽  
Author(s):  
Fang Xie ◽  
Xinxin Ding ◽  
Qing-Yu Zhang
Keyword(s):  
Cytochrome P450 ◽  
Drug Disposition ◽  
Cytochrome P450 Enzymes

scholarly journals Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine

2008 ◽  
Vol 36 (8) ◽  
pp. 1637-1649 ◽  
Author(s):  
Robin E. Pearce ◽  
Wei Lu ◽  
YongQiang Wang ◽  
Jack P. Uetrecht ◽  
Maria Almira Correia ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
Human Cytochrome

Role of cytochrome P450 enzymes in fimasartan metabolism in vitro

2018 ◽  
Vol 115 ◽  
pp. 375-384 ◽  
Author(s):  
Young Jae Choi ◽  
Ji-Yoon Lee ◽  
Chang Seon Ryu ◽  
Yong Ha Chi ◽  
Soo Heui Paik ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes

scholarly journals Role of Mouse Cytochrome P450 Enzymes of the Cyp2abfgs Subfamilies in the Induction of Lung Inflammation by Cigarette Smoke Exposure

2019 ◽  
Vol 172 (1) ◽  
pp. 123-131
Author(s):  
Matthew Hartog ◽  
Qing-Yu Zhang ◽  
Xinxin Ding
Keyword(s):  
Cytochrome P450 ◽  
Tobacco Smoke ◽  
Lung Inflammation ◽  
Inflammatory Cells ◽  
Lavage Fluid ◽  
Cigarette Smoke Exposure ◽  
Histopathological Analysis ◽  
Cytochrome P450 Enzymes

Abstract Many constituents of tobacco smoke (TS) require bioactivation to exert toxic effects; however, few studies have examined the role of bioactivation enzymes in the adverse effects of TS exposure. This knowledge gap is a major source of uncertainty for risk assessment and chemoprevention efforts. Our aim is to test the hypothesis that cytochrome P450 (P450) enzyme-mediated bioactivation is essential to the development of TS exposure-induced lung toxicity, by determining the contributions of P450 enzymes in the mouse Cyp2abfgs gene subfamilies to environmental tobacco smoke (ETS)-induced lung inflammation. Adult female wildtype (WT) and Cyp2abfgs-null mice (both on C57BL/6J background) were exposed to filtered air or ETS, intermittently, for 1 or 2 weeks. Lung inflammation was assessed by quantification of inflammatory cells, cytokines, chemokines, and proteins in bronchoalveolar lavage fluid (BALF) and histopathological analysis. Glutathione (GSH) conjugates of 2 ETS constituents, naphthalene (NA), and 3-methylindole (3MI), were measured in mice exposed to ETS for 4 h. Persistent macrophagic and neutrophilic lung inflammation was observed in ETS-exposed WT mice; the extent of which was significantly reduced in ETS-exposed Cyp2abfgs-null mice. Levels of proinflammatory cytokines and chemokines, along with the total protein concentration, were increased in cell-free BALF from ETS-exposed WT mice, but not Cyp2abfgs-null mice. Additionally, GSH conjugates of NA and 3MI were detected in the lungs of WT, but not Cyp2abfgs-null, mice following ETS exposure. These results provide the first in vivo evidence that the mouse Cyp2abfgs gene cluster plays an important role in ETS-induced lung inflammation.

Role of individual human cytochrome P450 enzymes in thein vitrometabolism of hydromorphone

Xenobiotica ◽  
2004 ◽  
Vol 34 (4) ◽  
pp. 335-344 ◽  
Author(s):  
S. A. Benetton ◽  
V. M. Borges ◽  
T. K. H. Chang ◽  
K. M. Mcerlane
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
Human Cytochrome ◽  
Individual Human

The Role of Cytochrome P450 Enzymes in the Metabolism of Risperidone and Its Clinical Relevance for Drug Interactions

2004 ◽  
Vol 5 (6) ◽  
pp. 573-579 ◽  
Author(s):  
R. Berecz ◽  
P. Dorado ◽  
A. Rubia ◽  
M. Caceres ◽  
I. Degrell ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Clinical Relevance ◽  
Cytochrome P450 Enzymes

The role of human cytochrome P450 enzymes in metabolism of acrylamidein vitro

2013 ◽  
Vol 23 (5) ◽  
pp. 346-351 ◽  
Author(s):  
Daria Kraus ◽  
Dennis Rokitta ◽  
Uwe Fuhr ◽  
Dorota Tomalik-Scharte
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
Human Cytochrome

Role of NF-κB in the Regulation of Cytochrome P450 Enzymes

2009 ◽  
Vol 10 (2) ◽  
pp. 164-178 ◽  
Author(s):  
Beshay Zordoky ◽  
Ayman El-Kadi
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes

scholarly journals Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

2020 ◽  
Author(s):  
Chenyang Zhang ◽  
Haoqing Shao ◽  
Dandan Li ◽  
Nenqun Xiao ◽  
Zhoujin Tan
Keyword(s):  
Cytochrome P450 ◽  
Intestinal Microbiota ◽  
Bacterial Flora ◽  
Shannon Index ◽  
Tryptophan Metabolism ◽  
Control Group ◽  
Cytochrome P450 Enzymes ◽  
Significant Difference ◽  
Tryptophan Derivatives

Abstract Background: Although reports have provided evidence that diarrhea caused by Folium sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial characteristic and specific mechanism are still unknown. The objective of our study was to investigate the mechanism of diarrhea caused by Folium sennae, which was associated with intestinal bacterial characteristic reshaping and metabolic abnormality. Results: For the intervention of Folium sennae extracts, Chao1 index and Shannon index were statistical decreased. The Beta diversity clusters of mice interfered by Folium sennae extracts were distinctly separated from control group. Combining PPI network analysis, cytochrome P450 enzymes metabolism was the main signaling pathway of diarrhea caused by Folium sennae. Moreover, 10 bacterial flora communities had statistical significant difference with Folium sennae intervention: the abundance of Paraprevotella, Streptococcus, Epulopiscium, Sutterella and Mycoplasma increased significantly; and the abundance of Adlercreutzia, Lactobacillus, Dehalobacterium, Dorea and Oscillospira reduced significantly. 7 of the 10 intestinal microbiota communities were related to the synthesis of tryptophan derivatives, which affected the transformation of aminotryptophan into L-tryptophan, leading to abnormal tryptophan metabolism in the host. Conclusions: Folium sennae targeted cytochrome P450 3A4 to alter intestinal bacterial characteristic and intervene the tryptophan metabolism of intestinal microbiota, such as Streptococcus, Sutterella and Dorea, which could be the intestinal microecological mechanism of diarrhea caused by Folium sennae extracts.

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