scholarly journals Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis

2015 ◽  
Vol 5 (6) ◽  
pp. 590-595 ◽  
Author(s):  
Yanxiong Gan ◽  
Shichao Zheng ◽  
Jan P.A. Baak ◽  
Silei Zhao ◽  
Yongfeng Zheng ◽  
...  
Keyword(s):  
Network Analysis ◽  
Protein Interaction ◽  
Protein Interaction Network ◽  
Interaction Network ◽  
Anti Inflammatory

scholarly journals Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis

2017 ◽  
Vol 8 (Suppl 1) ◽  
pp. S20-S21 ◽  
Author(s):  
Akram Safaei ◽  
Mostafa Rezaei Tavirani ◽  
Mona Zamanian Azodi ◽  
Alireza Lashay ◽  
Seyed Farzad Mohammadi ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Network Analysis ◽  
Laser Therapy ◽  
Protein Interaction ◽  
Protein Interaction Network ◽  
Interaction Network ◽  
Protein Protein Interaction ◽  
Protein Protein Interaction Network

scholarly journals Microarray analysis of novel genes involved in HSV-2 infection

2021 ◽  
Author(s):  
Hao Zhang ◽  
Tao Liu
Keyword(s):  
Immune System ◽  
Network Analysis ◽  
Protein Interaction ◽  
Protein Interaction Network ◽  
Experimental Studies ◽  
Interaction Network ◽  
The Body ◽  
Gene Analysis ◽  
Functional Enrichment ◽  
Skin Immune System

Abstract Background: Herpes simplex virus type 2 infects the body and becomes an incurable and recurring disease. The pathogenesis of HSV-2 infection is not completely clear.Methods: We analyze the GSE18527 dataset in the GEO database in this paper to obtain distinctively displayed genes(DDGs)in the total sequential RNA of the biopsies of normal and lesioned skin groups, healed skin and lesioned skin groups of genital herpes patients, respectively.The related data of 3 cases of normal skin group, 4 cases of lesioned group and 6 cases of healed group were analyzed.The histospecific gene analysis , functional enrichment and protein interaction network analysis of the differential genes were also performed, and the critical components were selected.Results: 40 up-regulated genes and 43 down-regulated genes were isolated by differential performance assay.Histospecific gene analysis of DDGs suggested that the most abundant system for gene expression was the skin, immune system and the nervous system.Through the construction of core gene combinations, protein interaction network analysis and selection of histospecific distribution genes, 17 associated genes were selected：CXCL10,MX1,ISG15,IFIT1,IFIT3,IFIT2,OASL,ISG20,RSAD2,GBP1,IFI44L,DDX58,USP18,CXCL11,GBP5,GBP4 and CXCL9.The above genes are mainly located in the skin, immune system, nervous system and reproductive system.Conclusion:This paper elucidates an effective approach for a new mechanism of HSV-2 infection, and the molecular mechanism of the selected core genes in the process of HSV-2 infection requires future experimental studies.

scholarly journals Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

PROTEOMICS ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 1700444 ◽  
Author(s):  
James E. Tomkins ◽  
Sybille Dihanich ◽  
Alexandra Beilina ◽  
Raffaele Ferrari ◽  
Nicolò Ilacqua ◽  
...  
Keyword(s):  
Network Analysis ◽  
Protein Interaction ◽  
Protein Interaction Network ◽  
Interaction Network
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